Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Larissa Tangeman"'
Autor:
Larissa Tangeman, Jeremy Keirsey, Samir Acharya, Joanna Groden, April Renee Sandy Gocha, Julia Harris Behnfeldt
Publikováno v:
Human Molecular Genetics. 27:1241-1251
The recQ-like helicase BLM interacts directly with topoisomerase IIα to regulate chromosome breakage in human cells. We demonstrate that a phosphosite tri-serine cluster (S577/S579/S580) within the BLM topoisomerase IIα-interaction region is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fa1d5da2275acbfe78370bb3faaaa8
https://doi.org/10.1093/hmg/ddy038
https://doi.org/10.1093/hmg/ddy038
Publikováno v:
Genes, Vol 7, Iss 9, p 69 (2016)
Genes
Genes; Volume 7; Issue 9; Pages: 69
Genes
Genes; Volume 7; Issue 9; Pages: 69
Defects in coordinated ribosomal RNA (rRNA) transcription in the nucleolus cause cellular and organismal growth deficiencies. Bloom’s syndrome, an autosomal recessive human disorder caused by mutated recQ-like helicase BLM, presents with growth def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064d5b7cec423b1ae7487e1e6be951ee
http://www.mdpi.com/2073-4425/7/9/69
http://www.mdpi.com/2073-4425/7/9/69
Autor:
Yiming Zhong, Dilara McCauley, Rosa Lapalombella, Katie Williams, Caroline Berglund, Emilia Mahoney, Yuh Min Chook, Dirk Daelemans, Sharon Shechter, Virginia M. Goettl, Michael Kauffman, Larissa Tangeman, Alicia Farmer, Vincent Sandanayaka, Qingxiang Sun, David M. Lucas, Amy J. Johnson, Sharon Shacham, John C. Byrd, Rajeswaran Mani, Sneha V. Gupta, Shruti Jha, Xiaokui Mo
The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. Existing XPO1-targeting agents lack selectivity and have been associated with significant toxicity. Small mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abe9be14fc5cc091ee882f9ec650bdf
https://lirias.kuleuven.be/handle/123456789/375596
https://lirias.kuleuven.be/handle/123456789/375596
Autor:
Sharon Shacham, Rosa Lapalombella, Katie Williams, Sharon Shechter, John C. Byrd, Jason A. Dubovsky, Shruti Jha, Amy J. Johnson, Dilara McCauley, Vincent Sandanayaka, Michael Kauffman, Larissa Tangeman, Danielle L. Chappell, Virginia M. Goettl
Publikováno v:
Blood. 120:2452-2452
Abstract 2452 CRM1 (chromosomal regional maintenance 1) or XPO1 (exportin 1) is the major protein that mediates nuclear export. XPO1 has been shown to be over-expressed in cancer cells leading to ineffective cytoplasmic localization of multiple tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0783c09d890610f1ca527a3930c58835
https://doi.org/10.1182/blood.v120.21.2452.2452
https://doi.org/10.1182/blood.v120.21.2452.2452