Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Larissa Nitschke"'
Autor:
Lathan Lucas, Larissa Nitschke, Brandon Nguyen, James A. Loehr, George G. Rodney, Thomas A. Cooper
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111104- (2024)
Summary: Skeletal muscle cells (myofibers) are elongated non-mitotic, multinucleated syncytia that have adapted a microtubule lattice. Microtubule-associated proteins (MAPs) play roles in regulating microtubule architecture. The most abundant MAP in
Externí odkaz:
https://doaj.org/article/b97167ad0f6049e7a56278c345d0f1e0
Autor:
James P. Orengo, Larissa Nitschke, Meike E. van der Heijden, Nicholas A. Ciaburri, Harry T. Orr, Huda Y. Zoghbi
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder. As disease progresses, motor neurons are affected, and their dysfunction contributes toward the inability to maintain proper respiratory function, a major driving forc
Externí odkaz:
https://doaj.org/article/81fe3c618f5b464189cef1cacb8d4ffe
Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1
Autor:
Larissa Nitschke, Stephanie L. Coffin, Eder Xhako, Dany B. El-Najjar, James P. Orengo, Elizabeth Alcala, Yanwan Dai, Ying-Wooi Wan, Zhandong Liu, Harry T. Orr, Huda Y. Zoghbi
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder characterized by motor incoordination, mild cognitive decline, respiratory dysfunction, and early lethality. It is caused by the expansion of the polyglutamine (polyQ)
Externí odkaz:
https://doaj.org/article/44cca890ba554a68a49c6326c4747b78
Autor:
Walid D. Fakhouri, Kareem Metwalli, Ali Naji, Sarah Bakhiet, Angela Quispe-Salcedo, Larissa Nitschke, Youssef A. Kousa, Brian C. Schutte
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Interferon Regulatory Factor 6 (IRF6) and TWIST1 are transcription factors necessary for craniofacial development. Human genetic studies showed that mutations in IRF6 lead to cleft lip and palate and mandibular abnormalities. In the mouse, w
Externí odkaz:
https://doaj.org/article/b269d22767a14456a5a09864fa5151e1
Publikováno v:
Nucleic acids research.
Loss of gene function can be compensated by paralogs with redundant functions. An example of such compensation are the paralogs of the Muscleblind-Like (MBNL) family of RNA-binding proteins that are sequestered and lose their function in Myotonic Dys
Autor:
Jessica W. Bertol, Shelby Johnston, Rabia Ahmed, Victoria K. Xie, Kelsea M. Hubka, Lissette Cruz, Larissa Nitschke, Marta Stetsiv, Jeremy P. Goering, Paul Nistor, Sally Lowell, Hanne Hoskens, Peter Claes, Seth M. Weinberg, Irfan Saadi, Mary C. Farach-Carson, Walid D. Fakhouri
Publikováno v:
Bertol, J W, Johnston, S, Ahmed, R, Xie, V K, Hubka, K M, Cruz, L, Nitschke, L, Stetsiv, M, Goering, J P, Nistor, P, Lowell, S, Hoskens, H, Claes, P, Weinberg, S M, Saadi, I, Farach-Carson, M C & Fakhouri, W D 2022, ' Twist1 interacts with beta/delta-Catenins during neural tube development and regulates fate transition in cranial neural crest cells ', Development, vol. 149, no. 15, dev200068 . https://doi.org/10.1242/dev.200068
Cell fate determination is a necessary and tightly regulated process for producing different cell types and structures during development. Cranial neural crest cells (CNCCs) are unique to vertebrate embryos and emerge from the neural plate borders in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4231605d112a6519e68db0c128687524
https://www.pure.ed.ac.uk/ws/files/288868363/dev200068.pdf
https://www.pure.ed.ac.uk/ws/files/288868363/dev200068.pdf
Autor:
Stephanie L. Coffin, Mark A. Durham, Larissa Nitschke, Eder Xhako, Amanda M. Brown, Jean-Pierre Revelli, Esmeralda Villavicencio Gonzalez, Tao Lin, Hillary P. Handler, Yanwan Dai, Alexander J. Trostle, Ying-Wooi Wan, Zhandong Liu, Roy V. Sillitoe, Harry T. Orr, Huda Y. Zoghbi
Publikováno v:
Neuron. 111:481-492.e8
Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however, only select populations of cells degenerate. The interaction of polyglutamine-expanded
Autor:
Kaifang Pang, Eder Xhako, Larissa Nitschke, Jennifer L. Johnson, Vincenzo A. Gennarino, Ambika Tewari, Stephanie L. Coffin, Zhandong Liu, Huda Y. Zoghbi, Francisco A. Blanco
Publikováno v:
Genes Dev
Identifying modifiers of dosage-sensitive genes involved in neurodegenerative disorders is imperative to discover novel genetic risk factors and potential therapeutic entry points. In this study, we focus on Ataxin-1 (ATXN1), a dosage-sensitive gene
Autor:
Tomas Obsil, Huda Y. Zoghbi, Lech-Gustav Milroy, Christian Ottmann, L. Brunsveld, Rebecca Jane Burnley, Carolyn J. Adamski, Jeremy Martin Davis, Rachel Davis, Elizabeth Rodriguez, Larissa Nitschke, Seppe Leysen, Lorenzo Soini, Tom Crabbe
Publikováno v:
Journal of Molecular Biology, 433(19):167174. Academic Press Inc.
Journal of Molecular Biology
Journal of Molecular Biology
Graphical abstract
Highlights • 14-3-3 was postulated to prevent cytoplasmic aggregation of Ataxin-1. • Experimental support for an anti-aggregation effect of 14-3-3 on Ataxin-1 is provided. • Structural studies suggest 14-3-3 reduces Atax
Highlights • 14-3-3 was postulated to prevent cytoplasmic aggregation of Ataxin-1. • Experimental support for an anti-aggregation effect of 14-3-3 on Ataxin-1 is provided. • Structural studies suggest 14-3-3 reduces Atax
Autor:
Walid D. Fakhouri, Larissa Nitschke, Shelby Johnston, Peter Claes, Irfan Saadi, Marta Stetsiv, Sally Lowell, Seth M. Weinberg, Lissette A. Cruz, Mary C. Farach-Carson, Jéssica Wildgrube Bertol, Rabia Ahmed, Victoria K. Xie, Kelsea M. Hubka, Paul A Nistor, Hanne Hoskens, Jeremy P. Goering
Cell fate determination is a necessary and tightly regulated process for producing different cell types and structures during development. Cranial neural crest cells (CNCCs) are unique to vertebrate embryos and emerge from the neural fold borders int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bda330aa8fc7d97c6cd4566d02a5b4a
https://doi.org/10.1101/2021.08.22.457283
https://doi.org/10.1101/2021.08.22.457283