Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Larissa M. Dorsch"'
Autor:
Maike Schuldt, Larissa M. Dorsch, Jaco C. Knol, Thang V. Pham, Tim Schelfhorst, Sander R. Piersma, Cris dos Remedios, Michelle Michels, Connie R. Jimenez, Diederik W. D. Kuster, Jolanda van der Velden
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Sex-differences in clinical presentation contribute to the phenotypic heterogeneity of hypertrophic cardiomyopathy (HCM) patients. While disease prevalence is higher in men, women present with more severe diastolic dysfunction and worse s
Externí odkaz:
https://doaj.org/article/a7d1201b49794d8bb3ab768cc56619f0
Autor:
Larissa M. Dorsch, Maike Schuldt, Cristobal G. dos Remedios, Arend F. L. Schinkel, Peter L. de Jong, Michelle Michels, Diederik W. D. Kuster, Bianca J. J. M. Brundel, Jolanda van der Velden
Publikováno v:
Cells, Vol 8, Iss 7, p 741 (2019)
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these highly abundant proteins likely stress the protein quality control (PQC) sys
Externí odkaz:
https://doaj.org/article/fa2ed62a178f49298ca7ce044fc72245
Autor:
Maarten P. van den Berg, Karin Y. van Spaendonck-Zwarts, Jan D. H. Jongbloed, Aryan Vink, Ludolf G. Boven, Bianca J.J.M. Brundel, Gideon J. du Marchie Sarvaas, Larissa M. Dorsch, Jolanda van der Velden, Albert J. H. Suurmeijer, Paul A. van der Zwaag, Diederik W. D. Kuster
Publikováno v:
International Journal of Cardiology, 323(1), 251-258. Elsevier Ireland Ltd
Dorsch, L M, Kuster, D W D, Jongbloed, J D H, Boven, L G, van Spaendonck-Zwarts, K Y, Suurmeijer, A J H, Vink, A, du Marchie Sarvaas, G J, van den Berg, M P, van der Velden, J, Brundel, B J J M & van der Zwaag, P A 2021, ' The effect of tropomyosin variants on cardiomyocyte function and structure that underlie different clinical cardiomyopathy phenotypes ', International Journal of Cardiology, vol. 323, no. 1, pp. 251-258 . https://doi.org/10.1016/j.ijcard.2020.08.101
International Journal of Cardiology, 323, 251-258. ELSEVIER IRELAND LTD
International journal of cardiology, 323, 251-258. Elsevier Ireland Ltd
Dorsch, L M, Kuster, D W D, Jongbloed, J D H, Boven, L G, van Spaendonck-Zwarts, K Y, Suurmeijer, A J H, Vink, A, du Marchie Sarvaas, G J, van den Berg, M P, van der Velden, J, Brundel, B J J M & van der Zwaag, P A 2021, ' The effect of tropomyosin variants on cardiomyocyte function and structure that underlie different clinical cardiomyopathy phenotypes ', International Journal of Cardiology, vol. 323, no. 1, pp. 251-258 . https://doi.org/10.1016/j.ijcard.2020.08.101
International Journal of Cardiology, 323, 251-258. ELSEVIER IRELAND LTD
International journal of cardiology, 323, 251-258. Elsevier Ireland Ltd
Background - Variants within the alpha-tropomyosin gene (TPM1) cause dominantly inherited cardiomyopathies, including dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathy. Here we investigated whether TPM1 variants observed in DCM a
Publikováno v:
The Journal of general physiology, 154(9). Rockefeller University Press
Schuldt, M, Dorsch, L, Kuster, D & van der Velden, J 2022, ' Cardiac muscle disease and therapeutic targets ', The Journal of general physiology, vol. 154, no. 9 . https://doi.org/10.1085/jgp.2021ecc47
Schuldt, M, Dorsch, L, Kuster, D & van der Velden, J 2022, ' Cardiac muscle disease and therapeutic targets ', The Journal of general physiology, vol. 154, no. 9 . https://doi.org/10.1085/jgp.2021ecc47
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. While ∼50% of patients with HCM carry a sarcomere gene mutation (sarcomere mutation-positive, SMP), the genetic background is unknown in the other half of the patients (sar
Autor:
Diederik W. D. Kuster, Maike Schuldt, Saskia Schlossarek, Jaco C. Knol, Thang V. Pham, Michiel Dalinghaus, Michelle Michels, Tim Schelfhorst, Connie R. Jimenez, Marie-Jo Moutin, Jolanda van der Velden, Sander R. Piersma, Jiayi Pei, Michal Mokry, Larissa M. Dorsch, Lucie Carrier, Magdalena Harakalova, Cris dos Remedios, Folkert W. Asselbergs
Publikováno v:
Circulation. Heart failure
Circulation. Heart failure, 2021, 14 (1), ⟨10.1161/CIRCHEARTFAILURE.120.007022⟩
Circulation. Heart failure, 14(1):e007022. Lippincott Williams & Wilkins
Circulation. Heart Failure
Circ Heart Fail
Circulation. Heart failure, 14(1). Lippincott Williams and Wilkins
Schuldt, M, Pei, J, Harakalova, M, Dorsch, L M, Schlossarek, S, Mokry, M, Knol, J C, Pham, T V, Schelfhorst, T, Piersma, S R, Dos Remedios, C, Dalinghaus, M, Michels, M, Asselbergs, F W, Moutin, M-J, Carrier, L, Jimenez, C R, van der Velden, J & Kuster, D W D 2021, ' Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy ', Circulation. Heart failure, vol. 14, no. 1, e007022 . https://doi.org/10.1161/CIRCHEARTFAILURE.120.007022
Circulation. Heart failure, Lippincott Williams & Wilkins, 2021, 14 (1), ⟨10.1161/CIRCHEARTFAILURE.120.007022⟩
Circulation. Heart failure, 14(1):e007022. Lippincott Williams and Wilkins
Circulation. Heart failure, 2021, 14 (1), ⟨10.1161/CIRCHEARTFAILURE.120.007022⟩
Circulation. Heart failure, 14(1):e007022. Lippincott Williams & Wilkins
Circulation. Heart Failure
Circ Heart Fail
Circulation. Heart failure, 14(1). Lippincott Williams and Wilkins
Schuldt, M, Pei, J, Harakalova, M, Dorsch, L M, Schlossarek, S, Mokry, M, Knol, J C, Pham, T V, Schelfhorst, T, Piersma, S R, Dos Remedios, C, Dalinghaus, M, Michels, M, Asselbergs, F W, Moutin, M-J, Carrier, L, Jimenez, C R, van der Velden, J & Kuster, D W D 2021, ' Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy ', Circulation. Heart failure, vol. 14, no. 1, e007022 . https://doi.org/10.1161/CIRCHEARTFAILURE.120.007022
Circulation. Heart failure, Lippincott Williams & Wilkins, 2021, 14 (1), ⟨10.1161/CIRCHEARTFAILURE.120.007022⟩
Circulation. Heart failure, 14(1):e007022. Lippincott Williams and Wilkins
Supplemental Digital Content is available in the text.
Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. While ≈50% of patients with HCM carry a sarcomere gene mutation (sarcomere mutation-positive, HCMSMP
Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. While ≈50% of patients with HCM carry a sarcomere gene mutation (sarcomere mutation-positive, HCMSMP
Autor:
Tea Kakuchaya, Denise M S van Marion, Natasja M.S. de Groot, Larissa M. Dorsch, Femke Hoogstra-Berends, Leo A. Bockeria, Bianca J.J.M. Brundel
Publikováno v:
Heart Rhythm, 17(1), 115-122. Elsevier
van Marion, D M S, Dorsch, L, Hoogstra-Berends, F, Kakuchaya, T, Bockeria, L, de Groot, N M S & Brundel, B J J M 2020, ' Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissue ', Heart Rhythm, vol. 17, no. 1, pp. 115-122 . https://doi.org/10.1016/j.hrthm.2019.07.010
Heart Rhythm, 17(1), 115-122. ELSEVIER SCIENCE INC
van Marion, D M S, Dorsch, L, Hoogstra-Berends, F, Kakuchaya, T, Bockeria, L, de Groot, N M S & Brundel, B J J M 2020, ' Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissue ', Heart Rhythm, vol. 17, no. 1, pp. 115-122 . https://doi.org/10.1016/j.hrthm.2019.07.010
Heart Rhythm, 17(1), 115-122. ELSEVIER SCIENCE INC
BACKGROUND: Heat shock proteins (HSPs) are important chaperones that regulate the maintenance of healthy protein quality control in the cell. Impairment of HSPs is associated with aging-related neurodegenerative and cardiac diseases. Geranylgeranylac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ad14105c969df3a2acaecd9aa3faaf
https://research.vumc.nl/en/publications/0b965480-1e3c-4ede-928e-da33e9c07eef
https://research.vumc.nl/en/publications/0b965480-1e3c-4ede-928e-da33e9c07eef
Autor:
Bianca J. J. M. Brundel, Diederik W. D. Kuster, Marit Wiersma, Maike Schuldt, Larissa M. Dorsch, Dora Knežević, Jolanda van der Velden
Publikováno v:
Dorsch, L M, Schuldt, M, Knežević, D, Wiersma, M, Kuster, D W D, van der Velden, J & Brundel, B J J M 2019, ' Untying the knot : protein quality control in inherited cardiomyopathies ', Pflugers Archiv European Journal of Physiology, vol. 471, no. 5, pp. 795-806 . https://doi.org/10.1007/s00424-018-2194-0
Pflugers Archiv
Pflugers Archiv
Mutations in genes encoding sarcomeric proteins are the most important causes of inherited cardiomyopathies, which are a major cause of mortality and morbidity worldwide. Although genetic screening procedures for early disease detection have been imp
Autor:
Arend F.L. Schinkel, Maike Schuldt, Bianca J.J.M. Brundel, Peter L. de Jong, Diederik W. D. Kuster, Cristobal G. dos Remedios, Michelle Michels, Jolanda van der Velden, Larissa M. Dorsch
Publikováno v:
Cells, Vol 8, Iss 7, p 741 (2019)
Dorsch, L M, Schuldt, M, dos Remedios, C G, Schinkel, A F L, de Jong, P L, Michels, M, Kuster, D W D, Brundel, B J J M & van der Velden, J 2019, ' Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy ', Cells, vol. 8, no. 7, 741 . https://doi.org/10.3390/cells8070741
Cells, 8(7):741. MDPI Multidisciplinary Digital Publishing Institute
Cells
Volume 8
Issue 7
Cells, 8(7):741. Multidisciplinary Digital Publishing Institute (MDPI)
Dorsch, L M, Schuldt, M, dos Remedios, C G, Schinkel, A F L, de Jong, P L, Michels, M, Kuster, D W D, Brundel, B J J M & van der Velden, J 2019, ' Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy ', Cells, vol. 8, no. 7, 741 . https://doi.org/10.3390/cells8070741
Cells, 8(7):741. MDPI Multidisciplinary Digital Publishing Institute
Cells
Volume 8
Issue 7
Cells, 8(7):741. Multidisciplinary Digital Publishing Institute (MDPI)
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these highly abundant proteins likely stress the protein quality control (PQC) sys
Autor:
Kristy Red-Horse, William R. Goodyer, Lei Tian, James B Hu, Michael Hesse, Haodi Wu, Paul J. M. Wijnker, Jan W. Buikema, Sean M. Wu, Daniel Lee, Yi Miao, K. Christopher Garcia, Joost P.G. Sluijter, Joy Y. Wu, David T. Paik, Aimee Beck, Larissa M. Dorsch, Srilatha Swami, Jolanda van der Velden, Pieter A. Doevendans, Benjamin Beyersdorf, Caroline Geisen, Guang Li, Sharon L. Paige, Alain van Mil, Renee G.C. Maas, Soah Lee, Nazan Puluca, Siyeon Rhee, Orlando Chirikian, Joseph C. Wu, Francisco X Galdos, Bernd K. Fleischmann, Stefan Jovinge, Maike Schuldt, Sneha Venkamatran, Vahid Serpooshan
Publikováno v:
Cell Stem Cell
Buikema, J W, Lee, S, Goodyer, W R, Maas, R G, Chirikian, O, Li, G, Miao, Y, Paige, S L, Lee, D, Wu, H, Paik, D T, Rhee, S, Tian, L, Galdos, F X, Puluca, N, Beyersdorf, B, Hu, J, Beck, A, Venkamatran, S, Swami, S, Wijnker, P, Schuldt, M, Dorsch, L M, van Mil, A, Red-Horse, K, Wu, J Y, Geisen, C, Hesse, M, Serpooshan, V, Jovinge, S, Fleischmann, B K, Doevendans, P A, van der Velden, J, Garcia, K C, Wu, J C, Sluijter, J P G & Wu, S M 2020, ' Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes ', Cell Stem Cell, vol. 27, no. 1, pp. 50-63 . https://doi.org/10.1016/j.stem.2020.06.001
Cell Stem Cell, 27(1), 50-63. Cell Press
Buikema, J W, Lee, S, Goodyer, W R, Maas, R G, Chirikian, O, Li, G, Miao, Y, Paige, S L, Lee, D, Wu, H, Paik, D T, Rhee, S, Tian, L, Galdos, F X, Puluca, N, Beyersdorf, B, Hu, J, Beck, A, Venkamatran, S, Swami, S, Wijnker, P, Schuldt, M, Dorsch, L M, van Mil, A, Red-Horse, K, Wu, J Y, Geisen, C, Hesse, M, Serpooshan, V, Jovinge, S, Fleischmann, B K, Doevendans, P A, van der Velden, J, Garcia, K C, Wu, J C, Sluijter, J P G & Wu, S M 2020, ' Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes ', Cell Stem Cell, vol. 27, no. 1, pp. 50-63 . https://doi.org/10.1016/j.stem.2020.06.001
Cell Stem Cell, 27(1), 50-63. Cell Press
Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (5-fo
Autor:
Larissa M. Dorsch, Michelle Michels, Bianca J.J.M. Brundel, C.G. dos Remedios, J. van der Velden, F.Z. Zitouny, Maike Schuldt, Diederik W. D. Kuster, R. Zaremba
Publikováno v:
Journal of Molecular and Cellular Cardiology. 120:11-12