Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Larissa M. Balogh"'
Publikováno v:
Journal of Pharmaceutical Sciences. 102:3252-3263
Species differences among membrane transporters can be remarkable and difficult to properly assess by conventional methods. Herein, we employed the first use of stable isotope labeling in mammals or stable isotope-labeled peptides combined with mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6c8c9225236ebb5a01311ef5583e22
https://doi.org/10.1002/jps.23582
https://doi.org/10.1002/jps.23582
Autor:
Larissa M. Balogh, William M. Atkins
Publikováno v:
Drug Metabolism Reviews. 43:165-178
Electrophilic products of lipid peroxidation are important contributors to the progression of several pathological states. The prototypical α,β-unsaturated aldehyde, 4-hydroxynonenal (HNE), triggers cellular events associated with oxidative stress,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8762a27c18f2cf20fc76da11331f21ae
https://doi.org/10.3109/03602532.2011.558092
https://doi.org/10.3109/03602532.2011.558092
Autor:
Charles W. Locuson, Sean Mahabir, Laura Hedges, Kathleen E. Sampson, Larissa M. Balogh, Stewart T. Dunn, Yurong Lai
Publikováno v:
Drug Metabolism and Disposition. 39:789-795
Neurological side effects consistent with ivermectin toxicity have been observed in dogs when high doses of the common heartworm prevention agent ivermectin are coadministered with spinosad, an oral flea prevention agent. Based on numerous reports im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934692805aa7f458aafa7049f3b17bf6
https://doi.org/10.1124/dmd.110.034827
https://doi.org/10.1124/dmd.110.034827
Autor:
Wade J. Adams, Steven R. Cox, Larissa M. Balogh, Vikas Kumar, Yurong Lai, Kathleen E. Sampson, Timothy G. Brayman, Jeffrey C. Stevens
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:936-944
N-({(5S)-3-[4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide (PNU-288034), an oxazolidinone antibiotic, was terminated in phase I clinical development because of insufficient exposure. Analysis of the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f4afda482ad8ae252c07ca00ab1804
https://doi.org/10.1124/jpet.110.170753
https://doi.org/10.1124/jpet.110.170753
Autor:
Ronald E. Stenkamp, Larissa M. Balogh, Kimberly A. Kripps, Kaspars Tars, Bengt Mannervik, William M. Atkins, Isolde Le Trong
Publikováno v:
Biochemistry. 48:7698-7704
The cytosolic glutathione transferases (GSTs)1 comprise a family of multifunctional enzymes that share similar overall topologies, dimer interactions, and glutathione- (GSH) binding sites, yet retain the capacity to detoxify a broad spectrum of elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4fb219a23ce0f990148059e04be578
https://doi.org/10.1021/bi900895b
https://doi.org/10.1021/bi900895b
Publikováno v:
Drug Metabolism and Disposition. 37:59-65
In vitro experiments were conducted to compare k(inact), K(I) and inactivation efficiency (k(inact)/K(I)) of cytochrome P450 (P450) 2C9 by tienilic acid and (+/-)-suprofen using (S)-flurbiprofen, diclofenac, and (S)-warfarin as reporter substrates. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e33e662d0db567adc10c864c9419cb
https://doi.org/10.1124/dmd.108.023358
https://doi.org/10.1124/dmd.108.023358
Autor:
Larissa M. Balogh, Yurong Lai
Publikováno v:
Transporters in Drug Development ISBN: 9781461482284
Membrane transporters act as physiological “gatekeepers” that regulate the distribution of endogenous and exogenous compounds. It is therefore imperative that drug discovery/development research considers the function and expression of drug trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f40195fe9bccf78444690f1d4d7f7706
https://doi.org/10.1007/978-1-4614-8229-1_5
https://doi.org/10.1007/978-1-4614-8229-1_5
Publikováno v:
Journal of Proteomics & Bioinformatics.
The reliable quantification of drug transport proteins is a key element that is necessary to establish relative scaling factors for human pharmacokinetic predictions and to account for pharmacokinetic variations across populations. Herein, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88332c3c5648cc20391ae5a3ed947b23
https://doi.org/10.4172/jpb.1000285
https://doi.org/10.4172/jpb.1000285
Autor:
Kenta Yoshida, Yurong Lai, Larissa M. Balogh, Kazuya Maeda, Yuichi Sugiyama, Yi-an Bi, Ayman El-Kattan, Emi Kimoto
Publikováno v:
Molecular pharmaceutics. 9(12)
Since the substrate specificities of OATP1B1, 1B3, and 2B1 are broad and overlapping, the contribution of each isoform to the overall hepatic uptake is of concern when assessing transporter-mediated drug-drug interactions (DDIs) or genetic polymorphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf47cbef8716c8ec11448305507719e
https://pubmed.ncbi.nlm.nih.gov/23082789
https://pubmed.ncbi.nlm.nih.gov/23082789
Autor:
Michael J. Dabrowski, Larissa M. Balogh, William M. Atkins, Terrance J. Kavanagh, Joseph K. Zolnerciks, Robert J. Greene
Publikováno v:
Chemical research in toxicology. 23(10)
4-Hydroxynonenal (HNE) is produced from arachidonic acid or linoleic acid during oxidative stress. Although HNE is formed in tissues as a racemate, enantiospecific HNE effects have not been widely documented, nor considered. Therefore, a panel of cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b675dba45a7f35faa7726bc3b03eb40
https://pubmed.ncbi.nlm.nih.gov/20873854
https://pubmed.ncbi.nlm.nih.gov/20873854