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of 20
pro vyhledávání: '"Larissa Lago"'
Autor:
Isaline Mees, Harvey Tran, Anne Roberts, Larissa Lago, Shanshan Li, Blaine R. Roberts, Anthony J. Hannan, Thibault Renoir
Publikováno v:
Molecular Neurobiology. 59:2456-2471
Protein phosphorylation plays a role in many important cellular functions such as cellular plasticity, gene expression, and intracellular trafficking. All of these are dysregulated in Huntington's disease (HD), a devastating neurodegenerative disorde
Publikováno v:
Metallomics : integrated biometal science.
Metal dyshomeostasis is a well-established consequence of neurodegenerative diseases and traumatic brain injury. While the significance of metals continues to be uncovered in many neurological disorders, their implication in repetitive mild traumatic
Autor:
Shalini S. Rao, Larissa Lago, Irene Volitakis, Jay J. Shukla, Gawain McColl, David I. Finkelstein, Paul A. Adlard
Publikováno v:
Neurotherapeutics. 18:2759-2761
Autor:
David Finkelstein, Shalini S Rao, Paul A. Adlard, Irene Volitakis, Gawain McColl, Larissa Lago, Jay J. Shukla
Publikováno v:
Neurotherapeutics
The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the classic neuropathology associated with cognitive dysfunction in tauopathies such as Alzheimer’s disease (AD). However, th
Autor:
Ian Birchall, Blaine R. Roberts, Larissa Lago, Kevin J. Barnham, Stephan Klatt, Soumya Mukherjee, Keyla Perez, Catriona McLean, Colin L. Masters
Publikováno v:
Brain Communications
Plaques that characterize Alzheimer’s disease accumulate over 20 years as a result of decreased clearance of amyloid-β peptides. Such long-lived peptides are subjected to multiple post-translational modifications, in particular isomerization. Usin
Autor:
Ian Birchall, Soumya Mukherjee, Kevin J. Barnham, Blaine Russell Roberts, Larissa Lago, Keyla Perez, Colin L. Masters, Stephan Klatt
Publikováno v:
Alzheimer's & Dementia. 16
Publikováno v:
Journal of Alzheimer's disease : JAD. 78(4)
Background Abnormally hyperphosphorylated tau is a defining pathological feature of tauopathies, such as Alzheimer's disease (AD), and accumulating evidence suggests a role for iron in mediating tau pathology that may lead to cognitive decline in the
Autor:
Shalini S, Rao, Stuart D, Portbury, Larissa, Lago, Gawain, McColl, David I, Finkelstein, Ashley I, Bush, Paul A, Adlard
Publikováno v:
Journal of Alzheimer's disease : JAD. 77(2)
Abnormally hyperphosphorylated tau is a defining pathological feature of tauopathies, such as Alzheimer's disease (AD), and accumulating evidence suggests a role for iron in mediating tau pathology that may lead to cognitive decline in these conditio
Publikováno v:
Journal of Chromatography A, 1616 . Art.Nr. 460806.
Highlights • NH4NO3, Tris-HCl, and NH4CH3COO are optimal buffers for use in SEC-ICP-MS metalloprotein analyses. • Optimal range of buffer concentration is 50–200 mM in SEC-ICP-MS. • 100 mM concentration reduces both protein column interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98119d42e2207706058141cc3e723a4a
http://oceanrep.geomar.de/51865/
http://oceanrep.geomar.de/51865/
Autor:
Philip Doble, Paul A. Adlard, Raquel Gonzalez de Vega, Shalini S Rao, Dominic J. Hare, Larissa Lago, David Clases, Lisa Bray
Publikováno v:
Metallomics : integrated biometal science. 12(2)
A dysregulation in the homeostasis of metals such as copper, iron and zinc is speculated to be involved in the pathogenesis of tauopathies, which includes Alzheimer's disease (AD). In particular, there is a growing body of evidence to support a role