Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Larissa De Sá Lima"'
Autor:
Ana Maria Orellana, Caio Henrique Mazucanti, Leticia Pavan dos Anjos, Larissa de Sá Lima, Elisa Mitiko Kawamoto, Cristoforo Scavone
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Klotho is an antiaging protein, and its levels decline with age and chronic stress. The exogenous administration of Klotho can enhance cognitive performance in mice and negatively modulate the Insulin/IGF1/PI3K/AKT pathway in terms of metabo
Externí odkaz:
https://doaj.org/article/5740c89bab104784b8902ee6be6d8599
Autor:
Alexandre Chagas Santana, Wellington Andraus, Dan Zimelewicz Oberman, Nícollas Nunes Rabelo, Filipe Miranda Oliveira Silva, Humberto Dellê, Rafael Pepineli, Edvaldo Leal de Moraes, Cristoforo Scavone, Larissa de Sá Lima, Sabrina Degaspari, Sérgio Brasil, Davi Jorge Fontoura Solla, Liliane Moreira Ruiz, Karina Andrighetti de Oliveira-Braga, Natalia Aparecida Nepomuceno, Paulo Manuel Pêgo-Fernandes, Stefan Gunther Tullius, Eberval Gadelha Figueiredo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Liver transplantation has come a long way and is now regarded as the gold standard treatment for end-stage liver failure. The great majority of livers utilized in transplantation come from brain-dead donors. A broad inflammatory response cha
Externí odkaz:
https://doaj.org/article/75148395e7e1446d9d765d116d6e8d60
Autor:
Martina Ribeiro, Julia Nachbar, Maria Oliveira, Amanda Siena, Isabela Melhado, Victoria Alves, Thiago Lima, Henrique Moriya, Larissa De Sá Lima, Ana Orellana, Ricardo Oliveira-Filho, Wothan Tavares-De-Lima, Cristoforo Scavone
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S288- (2023)
Externí odkaz:
https://doaj.org/article/5ffee398a1a449d59a28c7569e4ec565
Autor:
Vinicius Wanatable Nakao, Caio Henrique Yokowama Mazucanti, Larissa de Sá Lima, Paloma Segura de Mello, Natacha Medeiros de Souza Port’s, Paula Fernanda Kinoshita, Jacqueline Alves Leite, Elisa Mitiko Kawamoto, Cristoforo Scavone
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The α-Klotho is an anti-aging protein that, when overexpressed, extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytoki
Externí odkaz:
https://doaj.org/article/68d440f26bb4423290f31765cc6d931a
Autor:
Marina Minto Cararo-Lopes, Débora Guerini Souza, Marcelo Ganzella, Gisele Hansel, Vanessa Kazlauckas, Paloma Segura De Mello, Larissa De Sá Lima, Elisa Mitiko Kawamoto, Luis Valmor Portela, Diogo Onofre Souza, Cristoforo Scavone, Ana Elisa Böhmer
Publikováno v:
Journal of Affective Disorders Reports, Vol 10, Iss , Pp 100394- (2022)
Background: Chronic immunosuppressive treatment with cyclosporine A (CsA) leads to multiple side effects, including some that occur in the central nervous system (CNS). This study aims to investigate the impact of long-term CsA treatment on anxiety b
Externí odkaz:
https://doaj.org/article/f99023825e4d4fe69ee5ec7611242149
Autor:
Alexandre Chagas Santana, Wellington Andraus, Filipe Miranda Oliveira Silva, Humberto Dellê, Rafael Pepineli, Edvaldo Leal de Moraes, Cristoforo Scavone, Larissa de Sá Lima, Sabrina Degaspari, Sergio Brasil, Davi Jorge Fontoura Solla, Liliane Moreira Ruiz, Karina Andrighetti de Oliveira-Braga, Natalia Aparecida Nepomuceno, Paulo Manuel Pêgo-Fernandes, Stefan Gunther Tullius, Eberval Gadelha Figueiredo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Brain death is characterized by a generalized inflammatory response that results in multiorgan damage. This process is mainly mediated through cytokines, which amplify graft immunogenicity. We investigated the immunological response in a bra
Externí odkaz:
https://doaj.org/article/c377023aeb3c49e0bf911f268d1c356c
Autor:
Jacqueline Alves Leite, Ana Maria Orellana, Diana Zukas Andreotti, Amanda Midori Matumoto, Natacha Medeiros de Souza Ports`, Larissa de Sá Lima, Elisa Mitiko Kawamoto, Carolina Demarchi Munhoz, Cristoforo Scavone
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1177 (2023)
Ouabain (OUA) is a cardiotonic steroid that modulates Na+, K+ -ATPase activity. OUA has been identified as an endogenous substance that is present in human plasma, and it has been shown to be associated with the response to acute stress in both anima
Externí odkaz:
https://doaj.org/article/6daf566e96194b5fbc3bcf6d9b4a827a
Autor:
Paula Fernanda Kinoshita, Ana Maria Orellana, Diana Zukas Andreotti, Giovanna Araujo de Souza, Natalia Prudente de Mello, Larissa de Sá Lima, Elisa Mitiko Kawamoto, Cristoforo Scavone
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2937 (2022)
Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain. TNF plays an essential role in neuroinflammation and re
Externí odkaz:
https://doaj.org/article/b01cca83c00a44229072e45465618de6
Autor:
Paula F. Kinoshita, Lidia M. Yshii, Ana Maria M. Orellana, Amanda G. Paixão, Andrea R. Vasconcelos, Larissa de Sá Lima, Elisa M. Kawamoto, Cristoforo Scavone
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Ouabain (OUA) is a cardiac glycoside that binds to Na+,K+-ATPase (NKA), a conserved membrane protein that controls cell transmembrane ionic concentrations and requires ATP hydrolysis. At nM concentrations, OUA activates signaling pathways th
Externí odkaz:
https://doaj.org/article/1adf6f5253cc4c8bb05fb066494c48ed
Autor:
Sabrina Degaspari, Carmen Branco Tzanno-Martins, Clarice Kazue Fujihara, Roberto Zatz, João Paulo Branco-Martins, Tania Araujo Viel, Hudson de Souza Buck, Ana Maria Marques Orellana, Ana Elisa Böhmer, Larissa de Sá Lima, Diana Zukas Andreotti, Carolina Demarchi Munhoz, Cristoforo Scavone, Elisa Mitiko Kawamoto
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125271 (2015)
Renal insufficiency can have a negative impact on cognitive function. Neuroinflammation and changes in klotho levels associate with chronic kidney disease (CKD) and may play a role in the development of cognitive impairment (CI). The present study ev
Externí odkaz:
https://doaj.org/article/f6dda5dd07c14607bb2fdd652920f4c1