Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production

Autor: Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Camila Marques, Maura Rosane Valerio Ikoma, Alexandrina Sartori

Publikováno v: Mediators of Inflammation, Vol 2013 (2013)

Experimental autoimmune encephalomyelitis (EAE) is an artificially induced demyelination of the central nervous system (CNS) that resembles multiple sclerosis in its clinical, histopathological, and immunological features. Activated Th1 and Th17 cell

Externí odkaz: https://doaj.org/article/c9e13e4b7b444de5af5314cab1f060cd

Review: Unravelling the Role of DNA Sensing in Alum Adjuvant Activity

Autor: Zara Gatt, Utku Gunes, Arianna Raponi, Larissa Camargo da Rosa, James M Brewer

Publikováno v: Discovery Immunology. 2

Public interest in vaccines is at an all-time high following the SARS-CoV-2 global pandemic. Currently, over 6 billion doses of various vaccines are administered globally each year. Most of these vaccines contain Aluminium-based adjuvants (alum), whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8ac581c2ff9b6971e79f1809535b79f
https://doi.org/10.1093/discim/kyac012

Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice

Autor: Lucy Buckingham, Joanne Davies, Joanne Boldison, Larissa Camargo da Rosa, Li Wen, F. Susan Wong

Publikováno v: Diabetologia
Boldison, J, Da Rosa, L C, Buckingham, L, Davies, J, Wen, L & Wong, F S 2019, ' Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice ', Diabetologia, vol. 62, no. 11, pp. 2052-2065 . https://doi.org/10.1007/s00125-019-04974-y

Aims/hypothesis Autoreactive B cells escape immune tolerance and contribute to the pathogenesis of type 1 diabetes. While global B cell depletion is a successful therapy for autoimmune disease, the fate of autoreactive cells during this treatment in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f375246bc49d02b3e32401a2ce3599
https://doi.org/10.1007/s00125-019-04974-y

Altered gut microbiota activate and expand insulin B15-23-Reactive CD8+ T-Cells

Autor: Simone Cuff, Li Wen, Jeremy Warden-Smith, Joanne Davies, F. Susan Wong, M. D. Lewis, James A. Pearson, Larissa Camargo da Rosa, Dimitri Kakabadse, Jian Peng

Publikováno v: Diabetes

Insulin is a major autoantigen in type 1 diabetes, targeted by both CD8 and CD4 T-cells. We studied an insulin-reactive T-cell receptor (TCR) alpha-chain transgenic non-obese diabetic (NOD) mouse on a TCRCα and proinsulin2 (PI2)-deficient background

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c3ab6de0ffc0291f254695a341eb0a

The impact of metabolic reprogramming on dendritic cell function

Autor: Janine Oliveira, Livia de Lima Thomaz, Gabriela Peron, Liana Verinaud, Larissa Camargo da Rosa, Rodolfo Thomé

Publikováno v: International immunopharmacology. 63

Dendritic cells (DCs) are antigen-presenting cells with the ability to activate naive T cells and direct the adaptive cellular immune response toward a specific profile. This is important, as different pathogens demand specific "profiles" of immune r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6937ec1c26a04b0674c58585b2b72513
https://pubmed.ncbi.nlm.nih.gov/30075432