Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Larissa A. Canadeo"'
Autor:
Xu Zhao, Jessica M. Perez, Peter A. Faull, Catherine Chan, Femke W. Munting, Larissa A. Canadeo, Can Cenik, Jon M. Huibregtse
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108820- (2024)
Summary: ISG15 is a type I interferon-induced ubiquitin-like modifier that functions in innate immune responses. The major human ISG15 ligase is hHERC5, a ribosome-associated HECT E3 that broadly ISGylates proteins cotranslationally. Here, we charact
Externí odkaz:
https://doaj.org/article/bea97f0a716b4da698a414645be006b8
Autor:
Caleb D. Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa A. Canadeo, Houda H. Harastani, Tamarand L. Darling, Adrianus C.M. Boon, Deborah J. Lenschow, Viraj Kulkarni, Jon M. Huibregtse
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103213- (2021)
Summary: The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attra
Externí odkaz:
https://doaj.org/article/2d628d8bb0d24099b4370a53d4b95c2c
Autor:
Caleb D. Swaim, Larissa A. Canadeo, Kristen J. Monte, Swati Khanna, Deborah J. Lenschow, Jon M. Huibregtse
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107772- (2020)
Summary: ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The signals that lead to the production of extracellula
Externí odkaz:
https://doaj.org/article/1854af2558b842cb99f3093f6d49f81a
Autor:
Larissa A. Canadeo, Caleb D. Swaim, Deborah J. Lenschow, Yi-Chieh Perng, Houda H. Harastani, Xu Zhao, Jon M. Huibregtse, Adrianus C. M. Boon, Tamarand L. Darling
Publikováno v:
bioRxiv
A recently emerged betacoronavirus, SARS-CoV-2, has led to a global health crisis that calls for the identification of effective therapeutics for COVID-19 disease. Coronavirus papain-like protease (PLpro) is an attractive drug target as it is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bff3018263f2a3facd280e4cdce757
https://europepmc.org/articles/PMC7337375/
https://europepmc.org/articles/PMC7337375/
Autor:
Larissa A. Canadeo, Caleb D. Swaim, Adrianus C. M. Boon, Deborah J. Lenschow, Yi-Chieh Perng, Xu Zhao, Viraj Kulkarni, Tamarand L. Darling, Houda H. Harastani, Jon M. Huibregtse, Varun Dwivedi
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103213-(2021)
iScience
iScience
The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attractive dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cc2c6418a2558c5002754feba36fb0
https://doi.org/10.1016/j.isci.2021.103213
https://doi.org/10.1016/j.isci.2021.103213
Publikováno v:
Methods in Enzymology
Ubiquitin and Ubiquitin-like Protein Modifiers
Ubiquitin and Ubiquitin-like Protein Modifiers
ISG15 is a ubiquitin-like protein (Ubl) that is expressed in response to Type 1 Interferon (IFN-α/β) signaling. Remarkably, ISG15 has three distinct biochemical activities involved in innate immune responses to viral and/or microbial infections. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1f4bba622e42c77cd7a36b7d75f3ee
https://doi.org/10.1016/bs.mie.2018.12.027
https://doi.org/10.1016/bs.mie.2018.12.027
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1844
UBAITs (Ubiquitin-Activated Interaction Traps) are reagents that capitalize on the biochemistry of the ubiquitin system to covalently trap transient protein-protein interactions. UBAITs consist of an affinity-tagged protein of interest fused to a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a874d4e32e11a1cfd317f2c8cb5c926
https://pubmed.ncbi.nlm.nih.gov/30242705
https://pubmed.ncbi.nlm.nih.gov/30242705
Publikováno v:
Methods in Molecular Biology ISBN: 9781493987054
UBAITs (Ubiquitin-Activated Interaction Traps) are reagents that capitalize on the biochemistry of the ubiquitin system to covalently trap transient protein-protein interactions. UBAITs consist of an affinity-tagged protein of interest fused to a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f034dbf9d258c7badc7f22f9344781d6
https://doi.org/10.1007/978-1-4939-8706-1_7
https://doi.org/10.1007/978-1-4939-8706-1_7
Publikováno v:
Biochimie. 114:127-133
Newly synthesized proteins can be misfolded or damaged because of errors during synthesis or environmental insults (e.g., heat shock), placing a significant burden on protein quality control systems. In addition, numerous human diseases are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d73b0978662b292fe2a038d6f582c9c
https://doi.org/10.1016/j.biochi.2015.02.006
https://doi.org/10.1016/j.biochi.2015.02.006
Autor:
Larissa A. Canadeo, Jon M. Huibregtse
Publikováno v:
Molecular Cell. 62:2-4
HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic process, and are misregulated in numerous diseases. Nonetheless, understanding of HECT E3s is limited by a paucity of selective and potent modulators. To ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e3f62e4c50a54d7ae8e28ffb2a565c
https://doi.org/10.1016/j.molcel.2016.03.023
https://doi.org/10.1016/j.molcel.2016.03.023