Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Larissa A, Maltseva"'
Publikováno v:
Cells, Vol 10, Iss 8, p 2124 (2021)
The heartbeat is initiated by pacemaker cells residing in the sinoatrial node (SAN). SAN cells generate spontaneous action potentials (APs), i.e., normal automaticity. The sympathetic nervous system increases the heart rate commensurate with the card
Externí odkaz:
https://doaj.org/article/bf30d6c61510495b993b39bb0774e18e
Autor:
Syevda G Sirenko, Dongmei Yang, Larissa A Maltseva, Mary S Kim, Edward G Lakatta, Victor A Maltsev
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185222 (2017)
Uptake and release calcium from the sarcoplasmic reticulum (SR) (dubbed "calcium clock"), in the form of spontaneous, rhythmic, local diastolic calcium releases (LCRs), together with voltage-sensitive ion channels (membrane clock) form a coupled syst
Externí odkaz:
https://doaj.org/article/8d885deea16742c3adf90690afcf3da6
Autor:
Oliver Monfredi, Larissa A Maltseva, Harold A Spurgeon, Mark R Boyett, Edward G Lakatta, Victor A Maltsev
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67247 (2013)
UNLABELLED:Spontaneous, submembrane local Ca(2+) releases (LCRs) generated by the sarcoplasmic reticulum in sinoatrial nodal cells, the cells of the primary cardiac pacemaker, activate inward Na(+)/Ca(2+)-exchange current to accelerate the diastolic
Externí odkaz:
https://doaj.org/article/ff061e47c6704d36906c88d7c89b15c6
Autor:
Larissa A. Maltseva, Oliver Monfredi, Syevda Tagirova, Victor A. Maltsev, Mary S. Kim, Bruce D. Ziman, Sean P. Parsons, Ashley N. Wirth, Alexander V. Maltsev, Maria Cristina Florio, Kenta Tsutsui, Daniel R. Riordon, Edward G. Lakatta, Michael D. Stern
Publikováno v:
Cell Calcium. 74:168-179
Current understanding of how cardiac pacemaker cells operate is based mainly on studies in isolated single sinoatrial node cells (SANC), specifically those that rhythmically fire action potentials similar to the in vivo behavior of the intact sinoatr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d47f35ea0bbe52c7ea1dd0cd7af46aa
https://doi.org/10.1016/j.ceca.2018.07.002
https://doi.org/10.1016/j.ceca.2018.07.002
Autor:
Bruce D. Ziman, Kirill V. Tarasov, Yelena S. Tarasova, Michael D. Stern, Jing Zhang, Jaclyn A. Brennan, Igor R. Efimov, Rostislav Bychkov, Alexander V. Maltsev, Syevda G. Sirenko-Tagirova, Mary S. Kim, Kenta Tsutsui, Victor A. Maltsev, Larissa A. Maltseva, Oliver Monfredi, Mingyi Wang, Edward G. Lakatta
Publikováno v:
Science signaling. 11(534)
The spontaneous rhythmic action potentials generated by the sinoatrial node (SAN), the primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that pump blood around the body. Although the heart rate of humans is substant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302cc69cdbd02d567bd16d90e6c9a9d8
https://pubmed.ncbi.nlm.nih.gov/29895616
https://pubmed.ncbi.nlm.nih.gov/29895616
Autor:
Michael D. Stern, Steven J. Sollott, Magdalena Juhaszova, Victor A. Maltsev, Edward G. Lakatta, Larissa A. Maltseva
Publikováno v:
The Journal of General Physiology
Numerical modeling indicates that hierarchical clustering of ryanodine receptors in cells of the sinoatrial node is crucial to the calcium clock and thereby to regulation of heart rate.
The sinoatrial node, whose cells (sinoatrial node cells [SA
The sinoatrial node, whose cells (sinoatrial node cells [SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d91334b9bc5ab104edb9b8dc70ff8a8
http://europepmc.org/articles/PMC4003189
http://europepmc.org/articles/PMC4003189
Autor:
Yelena S. Tarasova, Edward G. Lakatta, Syevda Sirenko, Harold A. Spurgeon, Ihor Zahanich, Larissa A. Maltseva, Kenneth R. Boheler, Victor A. Maltsev, Michael D. Stern
Publikováno v:
Journal of Molecular and Cellular Cardiology. 50:66-76
There is an intense interest in differentiating embryonic stem cells to engineer biological pacemakers as an alternative to electronic pacemakers for patients with cardiac pacemaker function deficiency. Embryonic stem cell-derived cardiocytes (ESCs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3357616439f5420a31dfc5bb9b08b0b
https://doi.org/10.1016/j.yjmcc.2010.09.018
https://doi.org/10.1016/j.yjmcc.2010.09.018
Autor:
Larissa A. Maltseva, Maxim Mikheev, Edward G. Lakatta, Anna Maltsev, Syevda Sirenko, Michael D. Stern, Victor A. Maltsev
Publikováno v:
Biophysical Journal. 100(2):271-283
In sinoatrial node cells of the heart, beating rate is controlled, in part, by local Ca2+ releases (LCRs) from the sarcoplasmic reticulum, which couple to the action potential via electrogenic Na+/Ca2+ exchange. We observed persisting, roughly period
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfe1a268de023f8a0aac4bbd023ba0c
Autor:
Kirill V. Tarasov, Rostialav Bychkov, Larissa A. Maltseva, Michael D. Stern, Kenta Tsutsui, Alexander V. Maltsev, Bruce D. Ziman, Oliver Monfredi, Mary S. Kim, Mingyi Wang, Syevda Sirenko, Edward G. Lakatta, Jaclyn A. Brennan, Igor R. Efimov, Victor A. Maltsev
Publikováno v:
Biophysical Journal. 114:622a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4dee221c42fe5075a854b5cac2e25c7
https://doi.org/10.1016/j.bpj.2017.11.3366
https://doi.org/10.1016/j.bpj.2017.11.3366
Autor:
Sean P. Parsons, Larissa A. Maltseva, Mary S. Kim, Victor A. Maltsev, Edward G. Lakatta, Oliver Monfredi, Alexander V. Maltsev, Syevda Sirenko, Kenta Tsutsui, Bruce D. Ziman
Publikováno v:
Biophysical Journal. 110(3):434a-435a
Spontaneous, rhythmic LCRs are an important factor of pacemaker function of SA node cells (SANC). LCRs operate within the context of a coupled-clock system involving interactions of plasma membrane and sarcoplasmic reticulum (SR)-based calcium clocks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b162d22a5804ea75cbe0a258ac340d