Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Larisa Y. Poluektova"'
Autor:
Grace Bybee, Youra Moeun, Weimin Wang, Kusum K. Kharbanda, Larisa Y. Poluektova, Srivatsan Kidambi, Natalia A. Osna, Murali Ganesan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHepatitis B virus (HBV) infection develops as an acute or chronic liver disease, which progresses from steatosis, hepatitis, and fibrosis to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). An increased stromal
Externí odkaz:
https://doaj.org/article/7dce5104bbc04432b98de9d85196fe16
Autor:
Chen Zhang, Hang Su, Emiko Waight, Larisa Y. Poluektova, Santhi Gorantla, Howard E. Gendelman, Prasanta K. Dash
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 149 (2024)
Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been reported that a
Externí odkaz:
https://doaj.org/article/969744862a8b47bf8345d2a165db9cb3
Autor:
Mojisola Ogunnaike, Srijanee Das, Samiksha S. Raut, Ashrafi Sultana, Mohammad Ullah Nayan, Murali Ganesan, Benson J. Edagwa, Natalia A. Osna, Larisa Y. Poluektova
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1208 (2023)
Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily the
Externí odkaz:
https://doaj.org/article/a23db97f23674b67869016e146198e37
Autor:
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-23 (2021)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in kind facilitates tau aggregation and neurodegeneration. Neuroinf
Externí odkaz:
https://doaj.org/article/9566142d7b6b497fa6e8c5d16550ee05
Autor:
Chen Zhang, Lubaba A. Zaman, Larisa Y. Poluektova, Santhi Gorantla, Howard E. Gendelman, Prasanta K. Dash
Publikováno v:
Pathogens, Vol 12, Iss 7, p 879 (2023)
A major roadblock to achieving a cure for human immunodeficiency virus type one (HIV-1) is the persistence of latent viral infections in the cells and tissue compartments of an infected human host. Latent HIV-1 proviral DNA persists in resting memory
Externí odkaz:
https://doaj.org/article/9d154a56697048e6800e5a50d32b9c81
Autor:
Moses New-Aaron, Siva Sankar Koganti, Murali Ganesan, Sharma Kanika, Vikas Kumar, Weimin Wang, Edward Makarov, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5346 (2023)
Liver disease is one of the leading comorbidities in HIV infection. The risk of liver fibrosis development is potentiated by alcohol abuse. In our previous studies, we reported that hepatocytes exposed to HIV and acetaldehyde undergo significant apop
Externí odkaz:
https://doaj.org/article/6c285c24e80e4a9199f05390a451df3a
Autor:
Srinivas Chava, C. Patrick Reynolds, Anup S. Pathania, Santhi Gorantla, Larisa Y. Poluektova, Don W. Coulter, Subash C. Gupta, Manoj K. Pandey, Kishore B. Challagundla
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 180-196 (2020)
Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite current aggressive treatment regimens, the prognosis for high‐risk NB patients remains poor, with the survival of less than 40%. Amplification/stabilization of
Externí odkaz:
https://doaj.org/article/d123863f70384ad887db192bc2a7c795
Autor:
Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha M. Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won-Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o
Externí odkaz:
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Saumi Mathews, Amanda Branch Woods, Ikumi Katano, Edward Makarov, Midhun B. Thomas, Howard E. Gendelman, Larisa Y. Poluektova, Mamoru Ito, Santhi Gorantla
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-15 (2019)
Abstract Background Microglia are the principal innate immune defense cells of the centeral nervous system (CNS) and the target of the human immunodeficiency virus type one (HIV-1). A complete understanding of human microglial biology and function re
Externí odkaz:
https://doaj.org/article/f493039c94474631b988061eda271b05
Autor:
Raghubendra Singh Dagur, Amanda Branch-Woods, Saumi Mathews, Poonam S. Joshi, Rolen M. Quadros, Donald W. Harms, Yan Cheng, Shana M. Miles, Samuel J. Pirruccello, Channabasavaiah B. Gurumurthy, Santhi Gorantla, Larisa Y. Poluektova
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as HIV-1 and to investigate multiple aspects of human immune system developm
Externí odkaz:
https://doaj.org/article/91d51f3b5b884400a233b29ea3e0d50e