Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Larisa M. Dedkova"'
Publikováno v:
Organic Letters. 25:1310-1314
Publikováno v:
ACS chemical biology.
The family of NF-κB transcriptional activators controls the expression of many genes, including those involved in cell survival and development. The family consists of homo- and heterodimers constituted by combinations of five subunits. Subunit p50
Publikováno v:
Chem Commun (Camb)
The NF-κB family of transcriptional activators is responsible for the expression of numerous genes that control key functions such as cell development and survival. Subunit p50 has been studied extensively and is known to include 13 tyrosines, but t
Publikováno v:
Biochemistry. 59:1217-1220
The identification of proteins that bind selectively to nucleic acid sequences is an ongoing challenge. We previously synthesized nucleobase amino acids designed to replace proteinogenic amino acids; these were incorporated into proteins to bind spec
Publikováno v:
Bioorg Med Chem
The elaboration of peptides and proteins containing non-proteinogenic amino acids has been realized using several complementary strategies, including chemical synthesis, ribosome- or non-ribosome-mediated elaboration, intein-mediated polypeptide rear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116070698acdb8823efd8aa1c670c640
https://europepmc.org/articles/PMC8217302/
https://europepmc.org/articles/PMC8217302/
Publikováno v:
Biochemistry
Nucleic acid binding proteins have been studied extensively, but the nature of the interactions that control their affinity, selectivity, and DNA and RNA functions is still not well understood. To understand the nature and functional consequences of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c0be3d9d6dad610b69fd41cb1f2b60
https://europepmc.org/articles/PMC7301883/
https://europepmc.org/articles/PMC7301883/
Publikováno v:
Biochemistry
The identification of proteins that bind selectively to nucleic acid sequences is an ongoing challenge. We previously synthesized nucleobase amino acids designed to replace proteinogenic amino acids; these were incorporated into proteins to bind spec
Publikováno v:
Biochemistry. 56:500-513
DNA polymerase β (Pol β) is a key enzyme in mammalian base excision repair (BER), contributing stepwise 5′-deoxyribose phosphate (dRP) lyase and “gap-filling” DNA polymerase activities. The lyase reaction is believed to occur via a β-elimina
Autor:
Sidney M. Hecht, Larisa M. Dedkova
The ribosome produces all of the proteins and many of the peptides present in cells. As a macromolecular complex comprised of both RNAs and proteins, it employs a constituent RNA to catalyze the formation of peptide bonds rapidly and with high fideli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad63452172541e916da6af301b16a81a
https://europepmc.org/articles/PMC6530915/
https://europepmc.org/articles/PMC6530915/
Publikováno v:
Bioorg Med Chem
We have synthesized several conformationally constrained dipeptide analogues as possible substrates for incorporation into proteins. These have included three cyclic dipeptides formed from Boc derivatives of 2,4-diaminobutyric acid, ornithine and lys