Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Larisa Adamian"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818(4):927-941
We discuss recent progresses in computational studies of membrane proteins based on physical models with parameters derived from bioinformatics analysis. We describe computational identification of membrane proteins and prediction of their topology f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5e5b6a66a88b24eed1287b642a4a8d
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808:1092-1102
Membrane proteins function in the diverse environment of the lipid bilayer. Experimental evidence suggests that some lipid molecules bind tightly to specific sites on the membrane protein surface. These lipid molecules often act as co-factors and pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea648a7c2e2607b5422224262826184c
https://doi.org/10.1016/j.bbamem.2010.12.008
https://doi.org/10.1016/j.bbamem.2010.12.008
Publikováno v:
Journal of Molecular Biology. 406:713-729
Detecting similarities between local binding surfaces can facilitate identification of enzyme binding sites, prediction of enzyme functions, as well as aid in our understanding of enzyme mechanisms. A challenging task is to construct a template of lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6962369d33ddfd983c0779afe30f2dc
https://doi.org/10.1016/j.jmb.2010.12.005
https://doi.org/10.1016/j.jmb.2010.12.005
Autor:
Jie Liang, Haohua Qian, David R. Pepperberg, Hélène A. Gussin, Feng Feng, Yan Yuan Tseng, Larisa Adamian, Niraj J. Muni
Publikováno v:
Protein Science. 18:2371-2383
The homopentameric rho1 GABA(C) receptor is a ligand-gated ion channel with a binding pocket for gamma-aminobutyric acid (GABA) at the interfaces of N-terminal extracellular domains. We combined evolutionary analysis, structural modeling, and experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b04e17c809d7bfe4beed697b17b7d5c
https://doi.org/10.1002/pro.247
https://doi.org/10.1002/pro.247
Publikováno v:
Photochemistry and Photobiology. 82:1426-1435
Genome sequencing projects resulted in the identification of a large number of new sequence homologs of archaeal rhodopsins in marine bacteria, fungi, and unicellular algae. It is an important task to unambiguously predict the functions of these new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff984690c9cc9989f1f95bcbbb33860
https://doi.org/10.1111/j.1751-1097.2006.tb09795.x
https://doi.org/10.1111/j.1751-1097.2006.tb09795.x
Autor:
Larisa Adamian, Jie Liang
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 63:1-5
Analysis of a database of structures of membrane proteins shows that membrane proteins composed of 10 or more transmembrane (TM) helices often contain buried helices that are inaccessible to phospholipids. We introduce a method for identifying TM hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaf3d55c26ae6a1f793120d08460b66
https://doi.org/10.1002/prot.20874
https://doi.org/10.1002/prot.20874
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 59:496-509
Characterizing the interactions between amino acid residues and lipid molecules is important for understanding the assembly of transmembrane helices and for studying membrane protein folding. In this study we develop TMLIP (TransMembrane helix-LIPid)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5934ccd3c248cb9f080369b61c76316b
https://doi.org/10.1002/prot.20456
https://doi.org/10.1002/prot.20456
Position-Dependence of Stabilizing Polar Interactions of Asparagine in Transmembrane Helical Bundles
Publikováno v:
Biochemistry. 42:6400-6407
Recent studies with model peptides and statistical analyses of the crystal structures of membrane proteins have shown that buried polar interactions contribute significantly to the stabilization of the three-dimensional structures of membrane protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467d6d521a66cb8e00f427c7d9b762bf
https://doi.org/10.1021/bi020573j
https://doi.org/10.1021/bi020573j
Autor:
Jie Liang, Larisa Adamian
Publikováno v:
Cell Biochemistry and Biophysics. 39:1-12
Ca2+-transporting adenosine triphosphatase (ATPase) of sarcoplasmic reticulum couples ATP hydrolysis with ion transport. Phosphorylation of the cytosolic region of the calcium-bound conformation (E1) of the protein leads to drastic conformational rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9fae2c348187307a5a409005561d26
https://doi.org/10.1385/cbb:39:1:1
https://doi.org/10.1385/cbb:39:1:1
Publikováno v:
Journal of Biomolecular NMR. 22:249-263
The NOAH/DIAMOD suite uses feedback filtering and self-correcting distance geometry to generate 3D structures from unassigned NOESY spectra. In this study we determined the minimum set of experiments needed to generate a high quality structure bundle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e743533e887facd16e9710bbce4c7f1
https://doi.org/10.1023/a:1014925824100
https://doi.org/10.1023/a:1014925824100