Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Larisa, Gheber"'
Publikováno v:
eLife, Vol 10 (2021)
In this study, we analyzed intracellular functions and motile properties of neck-linker (NL) variants of the bi-directional S. cerevisiae kinesin-5 motor, Cin8. We also examined – by modeling – the configuration of H-bonds during NL docking. Decr
Externí odkaz:
https://doaj.org/article/9e18f7c697594ea6acf4979948104de7
Autor:
Tatyana Bodrug, Elizabeth M Wilson-Kubalek, Stanley Nithianantham, Alex F Thompson, April Alfieri, Ignas Gaska, Jennifer Major, Garrett Debs, Sayaka Inagaki, Pedro Gutierrez, Larisa Gheber, Richard J McKenney, Charles Vaughn Sindelar, Ronald Milligan, Jason Stumpff, Steven S Rosenfeld, Scott T Forth, Jawdat Al-Bassam
Publikováno v:
eLife, Vol 9 (2020)
Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tai
Externí odkaz:
https://doaj.org/article/df2534919cf44fd39e58c822475e8f4e
Autor:
Jawdat Al-Bassam, Sudhir Kumar Singh, Mary Popov, Larisa Gheber, Sayaka Inagaki, Himanshu Pandey, Steven S. Rosenfeld, Mayan Sadan, Raz Zarivach, Geula Davidov, Meenakshi Singh
Publikováno v:
Cellular and Molecular Life Sciences. 78:6051-6068
Two modes of motility have been reported for bi-directional kinesin-5 motors: (a) context-dependent directionality reversal, a mode in which motors undergo persistent minus-end directed motility at the single-molecule level and switch to plus-end dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68a108e7499f49f3f62bce4f22658f4
https://doi.org/10.1007/s00018-021-03891-x
https://doi.org/10.1007/s00018-021-03891-x
Autor:
Himanshu, Pandey, Tatiana, Zvagelsky, Mary, Popov, Mayan, Sadan, Neta, Yanir, Alina, Goldstein-Levitin, Nurit, Siegler, Shira, Hershfinkel, Yahel, Abraham, Roy, Abraham, Levi A, Gheber, Larisa, Gheber
Publikováno v:
Journal of visualized experiments : JoVE. (180)
The mitotic bipolar kinesin-5 motors perform essential functions in spindle dynamics. These motors exhibit a homo-tetrameric structure with two pairs of catalytic motor domains, located at opposite ends of the active complex. This unique architecture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5a32107818f87709617d0a670fbc6ba
https://pubmed.ncbi.nlm.nih.gov/35679598
https://pubmed.ncbi.nlm.nih.gov/35679598
Autor:
Gary J. Brouhard, Scott Forth, Tatyana Bodrug, Larisa Gheber, Jawdat Al-Bassam, Jennifer Major, Steven S. Rosenfeld, Malina K. Iwanski, Himanshu Pandey, Adam G. Hendricks, Stanley Nithiananatham, Ignas Gaska, Sayaka Inagaki
The conserved kinesin-5 bipolar tetrameric motors slide apart microtubules during mitotic spindle assembly and elongation. Kinesin-5 bipolar organization originates from its conserved tetrameric helical minifilament, which position the C-terminal tai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c244382329a52af5e364281a56394d
https://doi.org/10.1101/2021.10.12.463902
https://doi.org/10.1101/2021.10.12.463902
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129255 (2015)
The mitotic Kinesin-5 motor proteins crosslink and slide apart antiparallel spindle microtubules, thus performing essential functions in mitotic spindle dynamics. Specific inhibition of their function by monastrol-like small molecules has been examin
Externí odkaz:
https://doaj.org/article/fe40188bc1b541feb3bd5de66aec4c01
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
In this study, we analyzed intracellular functions and motile properties of neck-linker (NL) variants of the bi-directional S. cerevisiae kinesin-5 motor, Cin8. We also examined – by modeling – the configuration of H-bonds during NL docking. Decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eff163dffd8381b3f65799b002131e
https://doi.org/10.7554/elife.71036
https://doi.org/10.7554/elife.71036
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6420, p 6420 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 6420, p 6420 (2021)
Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3868ff55da7be989d18ed551c4e96720
http://europepmc.org/articles/PMC8232732
http://europepmc.org/articles/PMC8232732
Publikováno v:
International Journal of Biological Sciences
Cdk1 has been found to phosphorylate the majority of its substrates in disordered regions, but some substrates maintain precise phosphosite positions over billions of years. Here, we examined the phosphoregulation of the kinesin-5, Cin8, using synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3012cbaffcd280f58813799c5f0f43
https://doi.org/10.7150/ijbs.30543
https://doi.org/10.7150/ijbs.30543