Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Lariat debranching enzyme"'
Autor:
Arundhati Mohanta, Kausik Chakrabarti
Publikováno v:
Biochimie. 180:134-142
Pre-mRNA processing and mRNA stability play direct roles in controlling protein abundance in a cell. Before the mRNA can be translated into a protein, the introns in the pre-mRNA transcripts need to be removed by splicing, such that exons can be liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e90d520193ce7096c16ec59e8f49f7e
https://doi.org/10.1016/j.biochi.2020.10.003
https://doi.org/10.1016/j.biochi.2020.10.003
Autor:
Thomas M. Menees
Publikováno v:
Annual Review of Virology. 7:189-202
Host cell factors are integral to viral replication. Human immunodeficiency virus 1 (HIV-1), the retroviral agent of acquired immune deficiency syndrome, requires several host factors for reverse transcription of the viral genomic RNA (gRNA) into DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cdd825d396a7c1c392975ff06dbb8b
https://doi.org/10.1146/annurev-virology-012720-094902
https://doi.org/10.1146/annurev-virology-012720-094902
Autor:
Thomas M. Menees
Publikováno v:
Molecular genetics and genomics : MGG. 296(2)
RNA debranching enzymes are 2'-5' phosphodiesterases found in all eukaryotes. Their main role is cleavage of intron RNA lariat branch points, promoting RNA turnover via exonucleases. Consistent with this role, cells with reduced RNA debranching enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488e74dc9cdb08cf5f5b624f0ab0fad1
https://pubmed.ncbi.nlm.nih.gov/33464395
https://pubmed.ncbi.nlm.nih.gov/33464395
Akademický článek
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Autor:
Elizabeth Ransey, Mark R. Macbeth, Annie Heroux, Sourav K. Dey, Subha R. Das, Eduardo Paredes
Publikováno v:
FEBS Letters. 591:2003-2010
The RNA lariat debranching enzyme, Dbr1, is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni2+ , Mn2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35aba53fad76ae164a68811f14bddaef
https://doi.org/10.1002/1873-3468.12677
https://doi.org/10.1002/1873-3468.12677
Autor:
Masad J. Damha, Jonathan P. Schuermann, Nathaniel E. Clark, Scott W. Stevens, P. John Hart, Alexander B. Taylor, Kenneth M. Roberts, Eric J. Montemayor, Paul F. Fitzpatrick, Adam Katolik, Stephen P. Holloway
Publikováno v:
Proceedings of the National Academy of Sciences. 113:14727-14732
Intron lariats are circular, branched RNAs (bRNAs) produced during pre-mRNA splicing. Their unusual chemical and topological properties arise from branch-point nucleotides harboring vicinal 2′,5′- and 3′,5′-phosphodiester linkages. The 2′,5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187b92c6daab59b3b512183822c1a509
https://doi.org/10.1073/pnas.1612729114
https://doi.org/10.1073/pnas.1612729114
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
María S. Mendoza-Figueroa, Eddy E. Alfonso-Maqueira, Cristina Vélez, Elisa I. Azuara-Liceaga, Selene Zárate, Nicolás Villegas-Sepúlveda, Odila Saucedo-Cárdenas, Jesús Valdés
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
Noncoding circular RNAs are widespread in the tree of life. Particularly, intron-containing circular RNAs which apparently upregulate their parental gene expression. Entamoeba histolytica, the causative agent of dysentery and liver abscesses in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69780fdb4490048b32437415be2a481
https://doi.org/10.3389/fcimb.2018.00255
https://doi.org/10.3389/fcimb.2018.00255
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
The RNA lariat debranching enzyme (Dbr1) has different functions in RNA metabolism, such as hydrolyzing the 2'-5' linkage in intron lariats, positively influencing Ty1 and HIV-1 retrotransposition, and modulating snRNP recycling during splicing react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5956392a8b3c94514a2be4e15fbfdf2e
https://www.frontiersin.org/article/10.3389/fcimb.2018.00228/full
https://www.frontiersin.org/article/10.3389/fcimb.2018.00228/full
Autor:
Anat Biran, Masad J. Damha, Michael J. Ciancanelli, Kerry Dobbs, Amos Etzioni, Osamu Ohara, Luísa Diogo, Mary Hasek, Stacy A. Hussong, Fabien G. Lafaille, Jean-Laurent Casanova, Yuval Itan, Lorenz Studer, Satoshi Okada, William G. Fairbrother, Lazaro Lorenzo, Veronica Galvan, Saleh Al-Muhsen, Gregory A. Smith, Rabih Halwani, Alexandra Dinis, Allison J Taggart, Aurélie Cobat, Nathaniel E. Clark, P. John Hart, Eduardo J. Garcia Reino, Brad R. Rosenberg, Luigi D. Notarangelo, Nicholas DeRosa, Adam Katolik, Emília Faria, Sonoko Sakata, Rie Fukuhara, Paula Garcia, Candice E. Van Skike, Maki Hyodo, Masao Kobayashi, Bastian Zimmer, Karen McCammon, Catherine A. Freije, Shen-Ying Zhang, Hanna Mandel, Jef D. Boeke, Miyuki Tsumura, Jingchuan Luo, Stephen P. Holloway, Elodie Pauwels, Laurent Abel, Stefano Volpi
Viruses that are typically benign sometimes invade the brainstem in otherwise healthy children. We report bi-allelic DBR1 mutations in unrelated patients from different ethnicities, each of whom had brainstem infection due to herpes simplex virus 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2010953adfec53c6901bb52f82566270
http://hdl.handle.net/11567/895025
http://hdl.handle.net/11567/895025
