A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice

Autor: Wake, Matthew, Palin, Anaïs, Belot, Audrey, Berger, Mathieu, Lorgouilloux, Megane, Bichon, Margot, Papworth, Jonathan, Bayliss, Luke, Grimshaw, Benjamin, Rynkiewicz, Natalie, Paterson, Jemima, Poindron, Alicia, Spearing, Erin, Carter, Emily, Hudson, Robyne, Campbell, Millie, Petzer, Verena, Besson-Fournier, Céline, Latour, Chloé, Largounez, Amélie, Gourbeyre, Ophélie, Fay, Alexis, Coppin, Hélène, Roth, Marie-Paule, Theurl, Igor, Germaschewski, Volker, Meynard, Delphine

Publikováno v: In Blood Advances 23 April 2024 8(8):1898-1907

Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

Autor: Belot, Audrey, Gourbeyre, Ophélie, Palin, Anais, Rubio, Aude, Largounez, Amélie, Besson-Fournier, Celine, Latour, Chloé, Lorgouilloux, Megane, Gallitz, Inka, Montagner, Alexandra, Polizzi, Arnaud, Régnier, Marion, Smati, Sarra, Zhang, An-Sheng, Diaz-Munoz, Manuel, Steinbicker, Andrea, Guillou, Hervé, Roth, Marie-Paule, Coppin, Hélène, Meynard, Delphine

Publikováno v: Haematologica
Haematologica, Ferrata Storti Foundation, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩
Haematologica, 2021, 106 (4), pp.1202-1206. ⟨10.3324/haematol.2019.237321⟩

International audience; The liver hormone hepcidin controls the main inflows of iron into plasma by binding to and inducing the degradation or the occlusion of the iron export activity of ferroportin, the only known cellular exporter of iron. When he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f448f7c0fa5f39da70266cfaf09528b
https://hal.inrae.fr/hal-02911817/document

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Autor: Benjamin Grimshaw, Erin Spearing, Delphine Meynard, Luke Bayliss, Audrey Belot, Matthew Wake, Volker Germaschewski, Jemima Paterson, Jonathan Papworth, Igor Theurl, Emily Carter, Anais Palin, Amelie Largounez, Natalie K. Rynkiewicz, Verena Petzer, Alicia Poindron, Robyne Hudson

Publikováno v: Blood. 134:3532-3532

Beta thalassemia is an inherited hemoglobinopathy caused by a genetic defect in beta-globin gene and characterised by ineffective erythropoiesis, iron overload, splenomegaly and anemia. Excessive EPO production, resulting from the anemia, has a suppr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20cca27c4178f1155aa92bc03a2be678
https://doi.org/10.1182/blood-2019-124075

Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR.

Autor: Belot A; IRSD U1220 INSERM., Gourbeyre O; IRSD U1220 INSERM., Palin A; IRSD U1220 INSERM., Rubio A; IRSD U1220 INSERM., Largounez A; IRSD U1220 INSERM., Besson-Fournier C; IRSD U1220 INSERM., Latour C; IRSD U1220 INSERM., Lorgouilloux M; IRSD U1220 INSERM., Gallitz I; University Hospital Muenster., Montagner A; INRA UMR1331 ToxAlim., Polizzi A; INRA UMR1331 ToxAlim., Régnier M; INRA UMR1331 ToxAlim., Smati S; INRA UMR1331 ToxAlim., Zhang AS; Oregon Health and Science University., Diaz-Munoz MD; Oregon Health and Science University., Steinbicker AU; University Hospital Muenster., Guillou H; INRA UMR1331 ToxAlim., Roth MP; IRSD U1220 INSERM., Coppin H; IRSD U1220 INSERM., Meynard D; IRSD U1220 INSERM.

Publikováno v: Haematologica [Haematologica] 2021 Apr 01; Vol. 106 (4), pp. 1202-1206. Date of Electronic Publication: 2021 Apr 01.