The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study

Autor: Sophia C. Morandi, Elio L. Herzog, Marion Munk, Marco Kreuzer, Carlo R. Largiadèr, Sebastian Wolf, Martin Zinkernagel, Denise C. Zysset-Burri

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-11 (2024)

Abstract Background The human gut microbiome (GM) is involved in inflammation and immune response regulation. Dysbiosis, an imbalance in this ecosystem, facilitates pathogenic invasion, disrupts immune equilibrium, and potentially triggers diseases i

Externí odkaz: https://doaj.org/article/4d7b3210704e4093b71376e158c6a45d

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

Autor: Ting Zhang, Alisa Ambrodji, Huixing Huang, Kelly J Bouchonville, Amy S Etheridge, Remington E Schmidt, Brianna M Bembenek, Zoey B Temesgen, Zhiquan Wang, Federico Innocenti, Deborah Stroka, Robert B Diasio, Carlo R Largiadèr, Steven M Offer

Publikováno v: eLife, Vol 13 (2024)

Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanis

Externí odkaz: https://doaj.org/article/f486b24826a64551bd611deb78f24793

Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study

Autor: Peter J. Neyer, Bérenger Kaboré, Christos T. Nakas, Britta Hartmann, Annelies Post, Salou Diallo, Halidou Tinto, Angelika Hammerer-Lercher, Carlo R. Largiadèr, Andre J. van der Ven, Andreas R. Huber

Publikováno v: Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023)

Abstract Background Asymptomatic Plasmodium falciparum parasitaemia forms a reservoir for the transmission of malaria disease in West Africa. Certain haemoglobin variants are known to protect against severe malaria infection. However, data on the pot

Externí odkaz: https://doaj.org/article/15dc7970e7eb49fe8acc1c950870e7d1

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Understanding the needs of women undergoing breast ultrasound: Are male radiologists still needed?

Autor: Sartoretti, Elisabeth^1,2 (AUTHOR), Largiadèr, Selina¹ (AUTHOR), Sartoretti, Thomas^1,2 (AUTHOR), Laures, Simin³ (AUTHOR), Walter, Martin Alexander^1,4 (AUTHOR), Monti, Eva¹ (AUTHOR), Füchsel, Ina⁵ (AUTHOR), Dettling, Mira⁵ (AUTHOR), Pfister, Stephan⁴ (AUTHOR), Dubsky, Peter⁶ (AUTHOR), Ort, Alexander¹ (AUTHOR), Sartoretti-Schefer, Sabine⁵ (AUTHOR), Meissnitzer, Matthias⁷ (AUTHOR), Hergan, Klaus⁷ (AUTHOR), Forstner, Rosemarie⁷ (AUTHOR), Matoori, Simon⁸ (AUTHOR), Bech- Hohenberger, Rasmus⁹ (AUTHOR), Froehlich, John M.⁴ (AUTHOR), Plümecke, Tino¹ (AUTHOR), Harder, Dorothee¹⁰ (AUTHOR)

Publikováno v: PLoS ONE. 11/8/2023, Vol. 18 Issue 11, p1-11. 11p.