Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Laramie D Lemon"'
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Akademický článek
A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations
Autor: Laramie D Lemon, Sneha Kannan, Kim Wai Mo, Miranda Adams, Haley G Choi, Alexander O D Gulka, Elise S Withers, Hasset T Nurelegne, Valeria Gomez, Reina E Ambrocio, Rhea Tumminkatti, Richard S Lee, Morris Wan, Milo B Fasken, Jennifer M Spangle, Anita H Corbett
Publikováno v: G3: Genes, Genomes, Genetics, Vol 12, Iss 7 (2022)
AbstractSomatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single his
Externí odkaz: https://doaj.org/article/4d79f600263649b8878492dc6f2abbc7
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4
Expansion of germline RPS20 mutation phenotype to include Diamond-Blackfan anemia
Autor: Payal P. Khincha, Yukimatsu Toh, Lucas C. Reineke, Laramie D. Lemon, M. Tarek Elghetany, Katie Bergstrom, Fujun Zhou, Lisa Mirabello, Alison A. Bertuch, Christopher L. Williams, Richard E. Lloyd, Danna K. Morris, Saleh Bhar, Neelam Giri, Sharon A. Savage, Blanche P. Alter
Publikováno v: Hum Mutat
Diamond-Blackfan anemia (DBA) is a ribosomopathy of variable expressivity and penetrance characterized by red cell aplasia, congenital anomalies, and predisposition to certain cancers, including early-onset colorectal cancer (CRC). DBA is primarily c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49dc970b98e54e81a0c28f56421708e
https://pubmed.ncbi.nlm.nih.gov/32790018
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5
Loss of Ku’s DNA end binding activity affects telomere length via destabilizing telomere-bound Est1 rather than altering TLC1 homeostasis
Autor: Alison A. Bertuch, Laramie D. Lemon, Danna K. Morris
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Saccharomyces cerevisiae telomerase, which maintains telomere length, is comprised of an RNA component, TLC1, the reverse transcriptase, Est2, and regulatory subunits, including Est1. The Yku70/Yku80 (Ku) heterodimer, a DNA end binding (DEB) protein,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e7efbe1477af2913f1aaa7ea0357c2
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6
Structural Insights into Yeast Telomerase Recruitment to Telomeres
Autor: Vincent Géli, Pierre Luciano, Laramie D. Lemon, Alison A. Bertuch, Hongwen Chen, David C. Zappulla, Evan P. Hass, Shaohua Shi, Ming Lei, Dmitri Churikov, Jing Xue, Jian Wu
Publikováno v: Cell
Cell, Elsevier, 2018, 172 (1-2), pp.331-343.e13. ⟨10.1016/j.cell.2017.12.008⟩
Cell, 2018, 172 (1-2), pp.331-343.e13. ⟨10.1016/j.cell.2017.12.008⟩
International audience; Telomerase maintains chromosome ends from humans to yeasts. Recruitment of yeast telomerase to telomeres occurs through its Ku and Est1 subunits via independent interactions with telomerase RNA (TLC1) and telomeric proteins Si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3b7b0e435381c9f31de33daa90adcb
https://hal.archives-ouvertes.fr/hal-01789543
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7
The Principal Role of Ku in Telomere Length Maintenance Is Promotion of Est1 Association with Telomeres
Autor: Jaime M. Williams, Laramie D. Lemon, Alison A. Bertuch, Faissal Ouenzar, Pascal Chartrand
Publikováno v: Genetics
Telomere length is tightly regulated in cells that express telomerase. The Saccharomyces cerevisiae Ku heterodimer, a DNA end-binding complex, positively regulates telomere length in a telomerase-dependent manner. Ku associates with the telomerase RN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1f7706fd3e9cd3da112ebba9c1b221
https://doi.org/10.1534/genetics.114.164707
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