Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Lara Toy"'
1
Fluorescent Ligand Enables Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2
Autor: Max Huber, Silas Wurnig, Lara Toy, Corinna Weiler, Nicole Merten, Evi Kostenis, Finn Hansen, Matthias Schiedel
Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays and fluorescence microsc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ce76e0737dc432caee3a2b8de5e8b2
https://doi.org/10.26434/chemrxiv-2023-d9d87-v2
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2
Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs
Autor: Dorothée Weikert, Matthias Schiedel, Maximilian Schmidt, Max Huber, Lara Toy
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein‐coupled receptors (GPCRs). Ligands targeting the IABS, so‐called intracellular allosteric antagonists, are highly promising compounds for p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f3b0391b40af2734e4a0821e15516d
https://opus4.kobv.de/opus4-fau/files/22752/CHEM_CHEM202202565.pdf
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4
Fluorescent ligands targeting the intracellular allosteric binding site of the chemokine receptor CCR2
Autor: Dorothée Weikert, Matthias Schiedel, Maximilian Schmidt, Max Huber, Lara Toy
Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays. Here, we report the str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d843fabacc11003ba8a5bd650a11b872
https://doi.org/10.26434/chemrxiv-2022-wg6cg-v2
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5
A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs
Autor: Max E. Huber, Lara Toy, Maximilian F. Schmidt, Hannah Vogt, Julian Budzinski, Martin F. J. Wiefhoff, Nicole Merten, Evi Kostenis, Dorothee Weikert, Matthias Schiedel
Publikováno v: Angewandte Chemie International Edition. 61
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled receptors (GPCRs). Starting from vercirnon, an intracellular C-C chemokine receptor type 9 (CCR9) antagonist and previous phase III cli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fef5fb7fb05c5e95175d7b5144c09e
https://doi.org/10.1002/anie.202116782
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