Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Lara Testai"'
Autor:
Eugenia Piragine, Martina De Felice, Lorenzo Germelli, Vanessa Brinkmann, Lorenzo Flori, Claudia Martini, Vincenzo Calderone, Natascia Ventura, Eleonora Da Pozzo, Lara Testai
Publikováno v:
Experimental Gerontology, Vol 194, Iss , Pp 112495- (2024)
Aging is one of the main risk factors for neurodegenerative disorders, which represent a global burden on healthcare systems. Therefore, identifying new strategies to slow the progression of brain aging is a compelling challenge. In this article, we
Externí odkaz:
https://doaj.org/article/2aafe5b68c084df8b5bb4c954508caf7
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 543 (2024)
Irisin is a myokine secreted under the influence of physical activity and exposure to low temperatures and through different exogenous stimuli by the cleavage of its precursor, fibronectin type III domain-containing protein 5 (FNDC5). It is mainly kn
Externí odkaz:
https://doaj.org/article/5964e6ba918f44a9bb760d544b28f1b2
Autor:
Lorenzo Flori, Rosangela Montanaro, Eleonora Pagnotta, Luisa Ugolini, Laura Righetti, Alma Martelli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Vincenzo Brancaleone, Lara Testai, Vincenzo Calderone
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3281 (2023)
Modulation of mitochondrial K channels represents a pharmacological strategy to promote cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing hydrogen sulfide (H2S), an endogenous pleiotropic gasotransmitter responsible f
Externí odkaz:
https://doaj.org/article/8e567d5631784c1c9c6073e4309f3f89
Autor:
Giada Benedetti, Federica Zabini, Luca Tagliavento, Francesco Meneguzzo, Vincenzo Calderone, Lara Testai
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1351 (2023)
Pomegranate (Punica granatum L.) is a polyphenol-rich edible food and medicinal plant of ancient origin, containing flavonols, anthocyanins, and tannins, with ellagitannins as the most abundant polyphenols. In the last decades, its consumption and sc
Externí odkaz:
https://doaj.org/article/f5466cdf84bf47d5be62c977d512c2b9
Autor:
Valentina Citi, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Simone Brogi, Lorenzo Flori, Era Gorica, Lara Testai, Alma Martelli, Vincenzo Calderone, Giuseppe Caliendo, Beatrice Severino
Publikováno v:
Journal of Advanced Research, Vol 27, Iss , Pp 41-53 (2021)
Introduction: The gasotransmitter hydrogen sulphide (H2S), an endogenous ubiquitous signalling molecule, is known for its beneficial effects on different mammalian systems. H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or
Externí odkaz:
https://doaj.org/article/8fc49f98c59742828951e1c1870ef95a
Publikováno v:
Journal of Advanced Research, Vol 27, Iss , Pp 99-113 (2021)
Background: The vascular endothelium represents a fundamental mechanical and biological barrier for the maintenance of vascular homeostasis along the entire vascular tree. Changes in its integrity are associated to several cardiovascular diseases, in
Externí odkaz:
https://doaj.org/article/77c6e92546d04c7eb6479e9410dad34c
Autor:
Giulia Bononi, Valentina Citi, Margherita Lapillo, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo
Publikováno v:
Molecules, Vol 27, Iss 19, p 6535 (2022)
Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases. In recent years, SIRT1-activating compounds have been demonstrated to exert cardio
Externí odkaz:
https://doaj.org/article/b3bb8f1226714db5a14dbf3ee80039d3
Autor:
Rafał P. Kampa, Lorenzo Flori, Aleksandra Sęk, Jacopo Spezzini, Simone Brogi, Adam Szewczyk, Vincenzo Calderone, Piotr Bednarczyk, Lara Testai
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1892 (2022)
Luteolin (LUT) is a well-known flavonoid that exhibits a number of beneficial properties. Among these, it shows cardioprotective effects, as confirmed by numerous studies. However, its effect on mitochondrial potassium channels, the activation of whi
Externí odkaz:
https://doaj.org/article/f4b9e1a05ead45e5b8be62f0e180bbf8
Autor:
Lorenzo Flori, Lorenzo Albanese, Vincenzo Calderone, Francesco Meneguzzo, Mario Pagliaro, Rosaria Ciriminna, Federica Zabini, Lara Testai
Publikováno v:
Foods, Vol 11, Iss 18, p 2799 (2022)
Citrus flavonoids are well-known for their beneficial effects at the cardiovascular and cardio-metabolic level, but often the encouraging in vitro results are not confirmed by in vivo approaches; in addition, the clinical trials are also inconsistent
Externí odkaz:
https://doaj.org/article/8b8421f29f6b4b7db3323169ea09d16a
Autor:
Giulia Bononi, Lorenzo Flori, Valentina Citi, Cecilia Acciai, Viviana Nocilla, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 339 (2022)
NAD+-dependent deacetylase SIRT1 regulates many different biological processes, thus being involved in pathogenic conditions such as metabolic diseases, neurogenerative disorders and cancer. Notably, experimental evidence underlined that the activati
Externí odkaz:
https://doaj.org/article/24b81f1a3d1b48dfa6c55d9ebbdd88cb