Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lara Planas-Paz"'
Autor:
Lara Planas‐Paz, Alicia Pliego‐Mendieta, Catherine Hagedorn, Domingo Aguilera‐Garcia, Martina Haberecker, Fabian Arnold, Marius Herzog, Lorenz Bankel, Roman Guggenberger, Sabrina Steiner, Yanjiang Chen, Abdullah Kahraman, Martin Zoche, Mark A Rubin, Holger Moch, Christian Britschgi, Chantal Pauli
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. Determining HRR deficiency (HRD) is of major clinical relevance as it is associated with therapeutic vulnerabilities and rem
Externí odkaz:
https://doaj.org/article/d874520ba4d8464eacd895ed33371d67
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.
Externí odkaz:
https://doaj.org/article/bfe690555e05477e9caae7da26bcc89a
Autor:
Jana Lucia Bangerter, Kim Jannis Harnisch, Yanjiang Chen, Catherine Hagedorn, Lara Planas-Paz, Chantal Pauli
Extraskeletal myxoid chondrosarcoma (EMC) is a malignant mesenchymal neoplasm of uncertain differentiation as classified by the WHO Classification of Tumours 2020. Although often associated with pronlonged survival, EMC has high rates of distant recu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5804305750ec0fa07f1a5e5a4d2d95cd
https://www.zora.uzh.ch/id/eprint/226325/
https://www.zora.uzh.ch/id/eprint/226325/
Autor:
Yanjiang Chen, Marius Herzog, Alicia Pliego-Mendieta, Marco Matteo Bühler, Kim Jannis Harnisch, Martina Haberecker, Fabian Arnold, Lara Planas-Paz, Chantal Pauli
Publikováno v:
Laboratory Investigation. 103:100039
Autor:
Lara Planas-Paz, Lamberto De Boni, Yanjiang Chen, Reid Shaw, Mark A. Rubin, Jonathan E Pauwels, Chantal Pauli, Brooke M. Emerling, Benjamin D. Hopkins, Carla Grandori
Publikováno v:
Mol Cancer Res
Pauli, Chantal; De Boni, Lamberto; Pauwels, Jonathan E; Chen, Yanjiang; Planas-Paz, Lara; Shaw, Reid; Emerling, Brooke M; Grandori, Carla; Hopkins, Benjamin D; Rubin, Mark A (2022). A Functional Precision Oncology Approach to Identify Treatment Strategies for Myxofibrosarcoma Patients. Molecular cancer research, 20(2), pp. 244-252. American Association for Cancer Research AACR 10.1158/1541-7786.MCR-21-0255
Pauli, Chantal; De Boni, Lamberto; Pauwels, Jonathan E; Chen, Yanjiang; Planas-Paz, Lara; Shaw, Reid; Emerling, Brooke M; Grandori, Carla; Hopkins, Benjamin D; Rubin, Mark A (2022). A Functional Precision Oncology Approach to Identify Treatment Strategies for Myxofibrosarcoma Patients. Molecular cancer research, 20(2), pp. 244-252. American Association for Cancer Research AACR 10.1158/1541-7786.MCR-21-0255
In this era of precision medicine, numerous workflows for the targeting of high-recurrent mutations in common tumor types have been developed, leaving patients with rare diseases with few options. Here, we implement a functional precision oncology ap
Autor:
Lara Planas-Paz, Chantal Pauli
Publikováno v:
Principles of Translational Science in Medicine ISBN: 9780128204931
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dd97cbef11f6946f71bd2aec0e0a808
https://doi.org/10.1016/b978-0-12-820493-1.00024-6
https://doi.org/10.1016/b978-0-12-820493-1.00024-6
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature communications. 13(1)
The Hippo/YAP pathway controls cell proliferation through sensing physical and spatial organization of cells. How cell-cell contact is sensed by Hippo signaling is poorly understood. Here, we identified the cell adhesion molecule KIRREL1 as an upstre
Autor:
Eckhard Lammert, Anna Branopolski, Laura Sophie Hilger, Sofia Urner, Taija Makinen, Molly R. Kelly-Goss, Lara Planas-Paz, Eloi Montanez, Lukas Stanczuk, Shayn M. Peirce, Bettina Pitter, Carina Henning
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
The EMBO Journal
Universidad de Barcelona
The EMBO Journal
Vascular endothelial growth factor receptor‐3 (VEGFR3) signalling promotes lymphangiogenesis. While there are many reported mechanisms of VEGFR3 activation, there is little understanding of how VEGFR3 signalling is attenuated to prevent lymphatic v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65aa941c7139ac5dfbcc9a5a13944e81
http://hdl.handle.net/2445/155805
http://hdl.handle.net/2445/155805
Autor:
Sebastian Bergling, Monika Pikiolek, Guglielmo Roma, Tianliang Sun, Felix Lohmann, Yi Yang, Vanessa Orsini, Philipp S. Hoppe, Feng Cong, Luigi Terracciano, Jan S. Tchorz, Tewis Bouwmeester, Lara Planas-Paz, Heinz Ruffner, Sjoerd J B Holwerda, Lapo Morelli
Publikováno v:
Cell Stem Cell. 26:97-107.e6
The existence of specialized liver stem cell populations, including AXIN2+ pericentral hepatocytes, that safeguard homeostasis and repair has been controversial. Here, using AXIN2 lineage tracing in BAC-transgenic mice, we confirm the regenerative po
Autor:
Monika Pikiolek, Jan S. Tchorz, Y. Yang, Tianliang Sun, Lara Planas-Paz, Vanessa Orsini, F. Cong
Publikováno v:
Journal of Hepatology. 68:S125-S126