Výsledky vyhledávání

Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors

Autor: K Abu Ajaj, Friederike I. Nollmann, P Perez Galan, S Chercheja, J Garcia Fernandez, Magnusson Johannes Pall, Steffen Daum, Koester Stephan David, Felix Kratz, Anna Warnecke, Lara Pes, Federico Medda

Publikováno v: Nucl Med Mol Imaging

PURPOSE: The purpose of this study was to investigate the albumin-binding compound (111)In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors. METHODS: (111)In-C4-DTPA was injected in healthy nude mice for phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51be6a0358b100c50bd55e730c043475
https://doi.org/10.1007/s13139-019-00587-w

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Autor: Javier Garcia Fernandez, Anna Warnecke, Serghei Chercheja, Heidi-Kristin Walter, Lara Pes, Felix Kratz, Federico Medda, Friederike I. Nollmann, Didier Rognan, Steffen Daum, Khalid Abu Ajaj, Patricia Perez Galan, Magnusson Johannes Pall, Koester Stephan David

Publikováno v: Journal of Controlled Release. 296:81-92

Auristatins are a class of highly cytotoxic tubulin-disrupting peptides, which have shown limited therapeutic effect as free agents in clinical trials. In our continuing effort to develop acid-sensitive albumin-binding anticancer drugs exploiting cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3b07851396b9736b65ff1737d620a1
https://doi.org/10.1016/j.jconrel.2019.01.010

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Development of a fluorescent cardiomyocyte specific binding probe

Autor: Lara Pes, Young Tai Kim, Ching-Hsuan Tung

Publikováno v: Bioorganic & Medicinal Chemistry. 24:1706-1717

Cardiomyocytes are the major component of the heart. Their dysfunction or damage could lead to serious cardiovascular diseases, which have claimed numerous lives around the world. A molecule able to recognize cardiomyocytes would have significant val

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972daf0d33f5a53fed6ea94e74feacde
https://doi.org/10.1016/j.bmc.2016.02.042

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Decidual β-carotene-15,15′-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia

Autor: Prem Puri, Balazs Kutasy, Francesca Paradisi, Lara Pes, Hiromizu Takahashi

Publikováno v: Pediatric Surgery International. 31:37-43

Retinoids are essential for fetal and lung development. Beta-carotene(BC) is the main dietary retinoid source and beta-carotene-15,15′-oxygenase-1 and 2 (Bcmo1,2) is the primary enzyme generating retinoid from BC in adult mammalian tissues. Placent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04940d447fd42f353a901d0309db2e45
https://doi.org/10.1007/s00383-014-3621-8

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Increased uptake of dietary retinoids at the maternal-fetal barrier in the nitrofen model of congenital diaphragmatic hernia

Autor: Prem Puri, Lara Pes, Florian Friedmacher, Balazs Kutasy, Francesca Paradisi

Publikováno v: Journal of Pediatric Surgery. 49:866-870

Background/Purpose The retinol signaling pathway is disrupted in congenital diaphragmatic hernia (CDH). Since there is no fetal retinol synthesis, maternal retinol has to cross the placenta. Nitrofen interferes with the retinol-binding protein (RBP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0061e92f601ccbb9f29393ea620f9626
https://doi.org/10.1016/j.jpedsurg.2014.01.014

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Bidentate iminodiacetate modified dendrimer for bone imaging

Autor: Lara Pes, Young Ho Kim, Ching-Hsuan Tung

Publikováno v: Bioorganicmedicinal chemistry letters. 27(5)

A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc4df988c6d8b40f7a2ee52dc84a806
https://pubmed.ncbi.nlm.nih.gov/28153357

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Akademický článek

Deconstructing design thinking as a tool for the implementation of a population health initiative

Autor: Caitlin Jarrett, Yara C. Baxter, Johannes Boch, Conrado Carrasco, Daniel Cobos Muñoz, Karina Mauro Dib, Lara Pessoa, Jasmina Saric, Mariana Silveira, Peter Steinmann

Publikováno v: Health Research Policy and Systems, Vol 20, Iss 1, Pp 1-18 (2022)

Abstract Background The translation of evidence-based practices and rapid uptake of innovations into global health practice is challenging. Design thinking is a consultative process involving multiple stakeholders and has been identified as a promisi

Externí odkaz: https://doaj.org/article/af19a4dc63794b668525c2431766008b

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Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Autor: Felix Kratz, Federico Medda, Javier Garcia Fernandez, Heidi-Kristin Walter, Serghei Chercheja, Anna Warnecke, Lara Pes, Patricia Perez Galan, Magnusson Johannes Pall, Friederike I. Nollmann, Khalid Abu Ajaj, Koester Stephan David

Publikováno v: Cancer Research. 78:3703-3703

Auristatins are highly cytotoxic antimitotic tubulin-binding peptides. Of this family, only Adcetris®, an antibody drug conjugate (ADC) derived from monomethyl auristatin E (MMAE), is approved and marketed. Other auristatins such as dolastatin 10, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7469cf806f1784d973caebf1dfe7eef
https://doi.org/10.1158/1538-7445.am2018-3703

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Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Autor: Felix Kratz, Federico Medda, Javier Garcia Fernandez, Heidi K. Walter, Friederike I. Nollmann, Lara Pes, Magnusson Johannes Pall, Koester Stephan David, Patricia Perez Galan, Khalid Abu Ajaj, Serghei Chercheja, Anna Warnecke

Publikováno v: Cancer Research. 78:1657-1657

Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis.1 Unfortunately, their narrow therapeutic window prevents a clinical application of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::466f9ca4145cfa741a9f3a066beaeb70
https://doi.org/10.1158/1538-7445.am2018-1657

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Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Autor: Javier Garcia Fernandez, Lara Pes, Heidi K. Walter, Friederike I. Nollmann, Federico Medda, Magnusson Johannes Pall, Felix Kratz, Anna Warnecke, Koester Stephan David, Serghei Chercheja, Patricia Perez Galan, Khalid Abu Ajaj

Publikováno v: Cancer Research. 78:2661-2661

Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis. Their potent anticancer activity made them attractive for drug development.1 Unfortun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f3ca8028e33eeb29be5711cb138dc59
https://doi.org/10.1158/1538-7445.am2018-2661

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