Výsledky vyhledávání - "Lara Pedro C"

Akademický článek

MVP expression in the prediction of clinical outcome of locally advanced oral squamous cell carcinoma patients treated with radiotherapy

Autor: Henríquez-Hernández Luis, Moreno Mercedes, Rey Agustín, Lloret Marta, Lara Pedro C

Publikováno v: Radiation Oncology, Vol 7, Iss 1, p 147 (2012)

Abstract Objective To explore the role of Major Vault Protein (MVP) in oral cavity squamous cell carcinoma patients. Subjects and Methods 131 consecutive patients suffering from oral cavity squamous cell carcinoma were included in the study. In the w

Externí odkaz: https://doaj.org/article/69c8d347ddcc4e8fa4b2de2d6b46e9d3

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Akademický článek

MVP and vaults: a role in the radiation response

Autor: Zimmermann Martina, Pruschy Martin, Lara Pedro C, Henríquez-Hernández Luis

Publikováno v: Radiation Oncology, Vol 6, Iss 1, p 148 (2011)

Abstract Vaults are evolutionary highly conserved ribonucleoproteins particles with a hollow barrel-like structure. The main component of vaults represents the 110 kDa major vault protein (MVP), whereas two minor vaults proteins comprise the 193 kDa

Externí odkaz: https://doaj.org/article/9176dccb0a6142b88174494829ea16ff

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Akademický článek

Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy

Autor: Bordón Elisa, Pinar Beatriz, Carmona-Vigo Ruth, Henríquez-Hernández Luis, Lloret Marta, Núñez María, Rodríguez-Gallego Carlos, Lara Pedro C

Publikováno v: Radiation Oncology, Vol 6, Iss 1, p 60 (2011)

Abstract Background Either higher levels of initial DNA damage or lower levels of radiation-induced apoptosis in peripheral blood lymphocytes have been associated to increased risk for develop late radiation-induced toxicity. It has been recently pub

Externí odkaz: https://doaj.org/article/8f163dd7704b486db07f99170e98818b

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Akademický článek

Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients

Autor: Rodriguez-Gallego Carlos, Bordon Elisa, Lara Pedro C, Henríquez-Hernández Luis, Pinar Beatriz, Lloret Marta, Nuñez Maria, De Almodovar Mariano

Publikováno v: Radiation Oncology, Vol 5, Iss 1, p 85 (2010)

Abstract Background DNA-damage assays, quantifying the initial number of DNA double-strand breaks induced by radiation, have been proposed as a predictive test for radiation-induced toxicity. Determination of radiation-induced apoptosis in peripheral

Externí odkaz: https://doaj.org/article/d39c7f854b6d489faa99c37e67a900f2

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Akademický článek

Hypermethylated 14-3-3-σ and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis

Autor: Martínez-Galán Joaquina, Arrabal Sandra, Linares-Fernández José, Torres Blanca, del Moral Rosario, Zurita Mercedes, Lara Pedro C, Oliver Francisco, Ruiz de Almodóvar José

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 217 (2010)

Abstract Background Numerous hypermethylated genes have been reported in breast cancer, and the silencing of these genes plays an important role in carcinogenesis, tumor progression and diagnosis. These hypermethylated promoters are very rarely found

Externí odkaz: https://doaj.org/article/4ef24788888d462c88d3b4736d6cc16d

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Akademický článek

Prediction of clinical toxicity in locally advanced head and neck cancer patients by radio-induced apoptosis in peripheral blood lymphocytes (PBLs)

Autor: Ruíz Ana, Lara Pedro C, Henríquez-Hernández Luis, Bordón Elisa, Pinar Beatriz, Rodríguez-Gallego Carlos, Lloret Marta

Publikováno v: Radiation Oncology, Vol 5, Iss 1, p 4 (2010)

Abstract Head and neck cancer is treated mainly by surgery and radiotherapy. Normal tissue toxicity due to x-ray exposure is a limiting factor for treatment success. Many efforts have been employed to develop predictive tests applied to clinical prac

Externí odkaz: https://doaj.org/article/c75622e5bb1d42f88a0339455f69cb94

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Akademický článek

Prediction of clinical toxicity in localized cervical carcinoma by radio-induced apoptosis study in peripheral blood lymphocytes (PBLs)

Autor: Lara Pedro C, Henríquez Hernández Luis Alberto, Bordón Elisa, Pinar Beatriz, Fontes Fausto, Rodríguez Gallego Carlos, Lloret Marta

Publikováno v: Radiation Oncology, Vol 4, Iss 1, p 58 (2009)

Abstract Background Cervical cancer is treated mainly by surgery and radiotherapy. Toxicity due to radiation is a limiting factor for treatment success. Determination of lymphocyte radiosensitivity by radio-induced apoptosis arises as a possible meth

Externí odkaz: https://doaj.org/article/1e172556e78144d086339cc588eb8509

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Akademický článek

Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression

Autor: Apolinario Rosa M, Clavo Bernardino, Lloret Marta, Lara Pedro C, Henríquez-Hernández Luis, Bordón Elisa, Fontes Fausto, Rey Agustín

Publikováno v: Radiation Oncology, Vol 4, Iss 1, p 29 (2009)

Abstract Oxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair through down regulating Ku70/80 expre

Externí odkaz: https://doaj.org/article/cd72a2fb196a423cba4b5c1ea9633069

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