Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lara Marrone"'
Autor:
Ian Casci, Karthik Krishnamurthy, Sukhleen Kour, Vadreenath Tripathy, Nandini Ramesh, Eric N. Anderson, Lara Marrone, Rogan A. Grant, Stacie Oliver, Lauren Gochenaur, Krishani Patel, Jared Sterneckert, Amanda M. Gleixner, Christopher J. Donnelly, Marc-David Ruepp, Antonella M. Sini, Emanuela Zuccaro, Maria Pennuto, Piera Pasinelli, Udai Bhan Pandey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
The exact molecular mechanisms driving FUS-mediated toxicity remain unclear. Here, the authors demonstrate that muscleblind (Mbl) is a novel modifier of FUS-associated ALS, with knockdown of endogenous Mbl suppressing neuromuscular junction defects a
Externí odkaz:
https://doaj.org/article/808f528e987e4f6fbf0a7d25207ff6ed
Autor:
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Hannes C.A. Drexler, Sascha Menninger, Gunther Zischinsky, Jan Eickhoff, Claudia Fröb, Prabesh Bhattarai, Guruchandar Arulmozhivarman, Lara Marrone, Antje Janosch, Kenjiro Adachi, Martin Stehling, Eric N. Anderson, Masin Abo-Rady, Marc Bickle, Udai Bhan Pandey, Michell M. Reimer, Caghan Kizil, Hans R. Schöler, Peter Nussbaumer, Bert Klebl, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Summary: Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neu
Externí odkaz:
https://doaj.org/article/d6324808720f45358bb83abf2c104f0a
Autor:
Lara Marrone, Ina Poser, Ian Casci, Julia Japtok, Peter Reinhardt, Antje Janosch, Cordula Andree, Hyun O. Lee, Claudia Moebius, Ellen Koerner, Lydia Reinhardt, Maria Elena Cicardi, Karl Hackmann, Barbara Klink, Angelo Poletti, Simon Alberti, Marc Bickle, Andreas Hermann, Udai Bhan Pandey, Anthony A. Hyman, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 375-389 (2018)
Summary: Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in human motor neurons has been challenging, thus hindering the identif
Externí odkaz:
https://doaj.org/article/8c3c165643d94092bf3823929978ee6c
Autor:
Lara Marrone, Christine Bus, David Schöndorf, Julia Catherine Fitzgerald, Manuela Kübler, Benjamin Schmid, Peter Reinhardt, Lydia Reinhardt, Michela Deleidi, Tanya Levin, Andrea Meixner, Barbara Klink, Michael Glatza, Christian Johannes Gloeckner, Thomas Gasser, Jared Sterneckert
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0192497 (2018)
Induced pluripotent stem cells (iPSCs) have recapitulated several aspects of Parkinson's disease (PD), but most iPSCs are derived from familial cases, which account for only about 15% of patients. Thus, while the emphasis has justifiably been on usin
Externí odkaz:
https://doaj.org/article/880fb56cc2ff42b4bad956b902f0d7d5
Autor:
Volker Kroehne, Vasiliki Tsata, Lara Marrone, Claudia Froeb, Susanne Reinhardt, Anne Gompf, Andreas Dahl, Jared Sterneckert, Michell M. Reimer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Endogenous oligodendrocyte progenitor cells (OPCs) are a promising target to improve functional recovery after spinal cord injury (SCI) by remyelinating denuded, and therefore vulnerable, axons. Demyelination is the result of a primary insult and sec
Externí odkaz:
https://doaj.org/article/454832a2d93d4924bad3fdc5be21a9cc
Autor:
Lara Marrone, Paolo M Marchi, Christopher P Webster, Raffaele Marroccella, Ian Coldicott, Steven Reynolds, João Alves-Cruzeiro, Zih-Liang Yang, Adrian Higginbottom, Mukhran Khundadze, Pamela J Shaw, Christian A Hübner, Matthew R Livesey, Mimoun Azzouz
Publikováno v:
Human Molecular Genetics
Hereditary spastic paraplegia type 15 (HSP15) is a neurodegenerative condition caused by the inability to produce SPG15 protein, which leads to lysosomal swelling. However, the link between lysosomal aberrations and neuronal death is poorly explored.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35f6183b3de31bbe7662bdddf7a4172
https://pubmed.ncbi.nlm.nih.gov/35313342
https://pubmed.ncbi.nlm.nih.gov/35313342
Publikováno v:
Expert opinion on biological therapy. 22(9)
Introduction\ud \ud Gene therapy provides the exciting opportunity of a curative single treatment for devastating diseases, eradicating the need for chronic medication. Adeno-associated viruses (AAVs) are among the most attractive vector carriers for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3112a2f3d764536a773924bdbbadb6ce
https://pubmed.ncbi.nlm.nih.gov/34904932
https://pubmed.ncbi.nlm.nih.gov/34904932
Autor:
Kurt J. De Vos, Marco Destro, Andrew J. Grierson, Raffaele Marroccella, Emma F. Smith, Victor Alfred, Darren Robinson, Guillaume M. Hautbergue, Luc Bousset, Laurent Brasseur, Allan C. Shaw, Ronald Melki, Stephen J. Ebbens, Christopher P. Webster, Laura Ferraiuolo, Christa G. Walther, Mimoun Azzouz, Lai Mei Wan, Paolo M. Marchi, Lara Marrone
Dipeptide repeat proteins (DPRs) are aggregation-prone polypeptides encoded by the pathogenic G4C2 repeat expansion in the C9orf72 gene, the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6426a970417041b495e4e719d1d7e1f
https://doi.org/10.1101/2021.10.11.463891
https://doi.org/10.1101/2021.10.11.463891
Autor:
Evangelia Karyka, Nelly Berrueta Ramirez, Christopher P Webster, Paolo M Marchi, Emily J Graves, Vinay K Godena, Lara Marrone, Anushka Bhargava, Swagat Ray, Ke Ning, Hannah Crane, Guillaume M Hautbergue, Sherif F El-Khamisy, Mimoun Azzouz
Publikováno v:
Life science alliance. 5(8)
Spinal muscular atrophy, the leading genetic cause of infant mortality, is a motor neuron disease caused by low levels of survival motor neuron (SMN) protein. SMN is a multifunctional protein that is implicated in numerous cytoplasmic and nuclear pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d46e398b54386c1303922357ff4aa0
https://pubmed.ncbi.nlm.nih.gov/35440492
https://pubmed.ncbi.nlm.nih.gov/35440492
Publikováno v:
Trends in Molecular Medicine. 28:79-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a23ee98e65082b3ec7dd8bd09cdfb9c
https://doi.org/10.1016/j.molmed.2021.09.007
https://doi.org/10.1016/j.molmed.2021.09.007