Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA

Autor: Priyanka Tripathi, Andrew J Thompson, Eleonora Aronica, Janja Božič, Lara Markič, Helena Motaln, Roman Fischer, Anja Pucer Janež, Raphael Heilig, Alfred Yamoah, Boris Rogelj, Anand Goswami, Youn-Bok Lee

Publikováno v: Brain : a journal of neurology 145(2), 684-699 (2022). doi:10.1093/brain/awab300
Bozič, J, Motaln, H, Janez, A P, Markič, L, Tripathi, P, Yamoah, A, Aronica, E, Lee, Y-B, Heilig, R, Fischer, R, Thompson, A J, Goswami, A & Rogelj, B 2022, ' Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA ', Brain, vol. 145, no. 2, pp. 684-699 . https://doi.org/10.1093/brain/awab300
Brain, 145(2), 684-699. Oxford University Press

Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translati

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