SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.

Autor: Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Julian Heinze, Anja Richter, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Felix Walper, Marie L Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Terry C Jones, Markus Morkel, Sandra Ciesek, Leif G Hanitsch, Marcus A Mall, Andreas C Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M Corman, Marcel A Müller, Christine Goffinet, Christian Drosten

Publikováno v: PLoS Biology, Vol 20, Iss 11, p e3001871 (2022)

Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC rema

Externí odkaz: https://doaj.org/article/f439c20a5aa647faba500c0b3fd9f88a

Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory

Autor: Rūta Veinalde, Gemma Pidelaserra-Martí, Coline Moulin, Lara M. Jeworowski, Linda Küther, Christian J. Buchholz, Dirk Jäger, Guy Ungerechts, Christine E. Engeland

Publikováno v: Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 43-58 (2022)

PD-1/PD-L1 checkpoint blockade has achieved unprecedented success in cancer immunotherapy. Nevertheless, many immune-excluded tumors are resistant to therapy. Combination with oncolytic virotherapy may overcome resistance by inducing acute inflammati

Externí odkaz: https://doaj.org/article/b0640d5bf54b4f37a29eefe3f960eb3d

Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron

Autor: Jakob Kreye, S. Momsen Reincke, Stefan Edelburg, Lara M. Jeworowski, Hans-Christian Kornau, Jakob Trimpert, Peter Hombach, Sophia Halbe, Volker Nölle, Martin Meyer, Stefanie Kattenbach, Elisa Sánchez-Sendin, Marie L. Schmidt, Tatjana Schwarz, Ruben Rose, Andi Krumbholz, Sophie Merz, Julia M. Adler, Kathrin Eschke, Azza Abdelgawad, Dietmar Schmitz, Leif E. Sander, Uwe Janssen, Victor M. Corman, Harald Prüss

Publikováno v: iScience 26(4), 106323 (2023). doi:10.1016/j.isci.2023.106323

The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case numbers and maintains a persistent demand for updated therapies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5e4fef9e23f2ee568fef415fea313a

Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists

Autor: Paul S. Backhaus, Rūta Veinalde, Laura Hartmann, Jessica E. Dunder, Lara M. Jeworowski, Jessica Albert, Birgit Hoyler, Tanja Poth, Dirk Jäger, Guy Ungerechts, Christine E. Engeland

Publikováno v: Viruses, Vol 11, Iss 10, p 914 (2019)

Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin

Externí odkaz: https://doaj.org/article/1118853372f84506bfe58b7fe879584d

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

Autor: Daniela Niemeyer, Saskia Stenzel, Talitha Veith, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Julian Heinze, Anja Richter, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M. Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Felix Walper, Marie L. Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Terry C. Jones, Markus Morkel, Sandra Ciesek, Leif G. Hanitsch, Marcus A. Mall, Andreas C. Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M. Corman, Marcel A. Müller, Christine Goffinet, Christian Drosten

Publikováno v: Niemeyer, Daniela; Stenzel, Saskia; Veith, Talitha; Schroeder, Simon; Friedmann, Kirstin; Weege, Friderike; Trimpert, Jakob; Heinze, Julian; Richter, Anja; Jansen, Jenny; Emanuel, Jackson; Kazmierski, Julia; Pott, Fabian; Jeworowski, Lara M.; Olmer, Ruth; Jaboreck, Mark-Christian; Tenner, Beate; Papies, Jan; Walper, Felix; Schmidt, Marie L.; ... (2022). SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. PLoS biology, 20(11), e3001871. Public Library of Science 10.1371/journal.pbio.3001871

Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c3293ea12289a5a44136329bcbe57e
https://pubmed.ncbi.nlm.nih.gov/36383605