Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lara Kevorkian"'
Autor:
Gareth C. G. Davies, Neesha Dedi, Paul S. Jones, Lara Kevorkian, David McMillan, Cristina Ottone, Monika-Sarah E. D. Schulze, Anthony Scott-Tucker, Roohi Tewari, Shauna West, Michael Wright, Tania F. Rowley
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTGremlin-1, a high-affinity antagonist of bone morphogenetic proteins (BMP)-2, −4, and −7, is implicated in tumor initiation and progression. Increased gremlin-1 expression, and therefore suppressed BMP signaling, correlates with poor prog
Externí odkaz:
https://doaj.org/article/b953f7c54c694fe2b318ac8406c9743d
Autor:
Paul Atherfold, Hanna Hailu, Louis Christodoulou, Lena E. D’Hooghe, Bryan Smith, Helene Margaret Finney, Frank R. Brennan, Stevan Shaw, Kerry Louise Tyson, Daniel John Lightwood, Andrea Kiessling, Kevin Greenslade, Omar Qureshi, Lara Kevorkian, Rebecca Munro, Kate L. Dixon, Rocio Lledo-Garcia, Shauna West, Christoph Meier, Matthew C. Catley, Kaushik Sarkar, Alison Turner, Roohi Tewari, Sophie P. Shaw
Publikováno v:
mAbs
Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), has been developed to reduce pathogenic IgG in autoimmune and alloimmune diseases. We document the antibody isolation and compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045641d5108e50151ed33d8046d2ce07
http://europepmc.org/articles/PMC6291300
http://europepmc.org/articles/PMC6291300
Autor:
Rodger A. Allen, Payne Andrew Charles, Emma J. Haagensen, Paul Bevan, Huw D. Thomas, Lara Kevorkian, Wolfgang A. Schmalix, David R. Newell, Ross J. Maxwell
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Tumours frequently have defects in multiple oncogenic pathways, e.g. MAPK and PI3K signalling pathways, and combinations of targeted therapies may be required for optimal activity. This study evaluated the novel MEK inhibitor WX-554 and the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7600e28d22367fb4649299acdcab60d
https://doi.org/10.1007/s00280-016-3186-4
https://doi.org/10.1007/s00280-016-3186-4
Autor:
David Young, Andrew E. Parker, K.L. Culley, Ian M. Clark, Tracey E. Swingler, Sara A. Illman, Jouko Lohi, Lara Kevorkian
Publikováno v:
Biochemical Journal. 427:391-400
MMP-28 (epilysin) is a recently cloned member of the MMP (matrix metalloproteinase) family. It is highly expressed in the skin by keratinocytes, the developing and regenerating nervous system and a number of other normal human tissues, as well as a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75669b7b41c5c73bf031a253fda67a6e
https://doi.org/10.1042/bj20091798
https://doi.org/10.1042/bj20091798
Autor:
Mary B. Goldring, Ursula R. Rodgers, Alison K. Surridge, Ian M. Clark, R. Norton, Jasmine G. Waters, Andrew E. Parker, Tracey E. Swingler, Rose K Davidson, Lara Kevorkian
Publikováno v:
Matrix Biology
The ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) family includes 19 secreted proteinases in man. ADAMTS16 is a recently cloned gene expressed at high levels in fetal lung and kidney and adult brain and ovary. The ADA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f55d9ab6bee70b771e75ad885e30eef
Autor:
Andrew E. Parker, Dylan R. Edwards, Simon T. Donell, Lara Kevorkian, Sarah Porter, Ian M. Clark, David Young, Lee Shepstone, C. Darrah, S.M. Brockbank
Publikováno v:
Arthritis & Rheumatism. 50:131-141
Objective To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA). Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee9239fa93fb03ab01d3872387c00a1
https://doi.org/10.1002/art.11433
https://doi.org/10.1002/art.11433
Autor:
Andrew Nesbitt, Terry Baker, Charlene Porter, Sylvia Armstrong-Fisher, Lara Kevorkian, Uma Mahadevan
Publikováno v:
Reproductive Toxicology. 64:39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a93859df67eaeb470da1097afca577
https://doi.org/10.1016/j.reprotox.2016.06.085
https://doi.org/10.1016/j.reprotox.2016.06.085
Publikováno v:
Journal of Crohn's and Colitis. 8:S83-S84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b582eccbb48aa6d0c9989e8553cd534f
https://doi.org/10.1016/s1873-9946(14)60171-9
https://doi.org/10.1016/s1873-9946(14)60171-9
Autor:
Jouko Lohi, Ursula R. Rodgers, Alison K. Surridge, Lara Kevorkian, Tracey E. Swingler, Sara A. Illman, K.L. Culley, Jasmine G. Waters, Andrew E. Parker, Ian M. Clark
Publikováno v:
Matrix Biology
Matrix metalloproteinase-28 (MMP-28, epilysin) is highly expressed in the skin by keratinocytes, the developing and regenerating nervous system and a number of other normal human tissues. In epithelial cells, over-expression of MMP-28 mediates irreve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd789a83d03f8a6ad4cf721e5e013e4
https://pubmed.ncbi.nlm.nih.gov/19375502
https://pubmed.ncbi.nlm.nih.gov/19375502
Publikováno v:
The Biochemical journal. 386(Pt 1)
The ADAMTSs (adisintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was first described in 1997, there has been a rapidly expanding body o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2519e6cea221c6053db500dfdc7c7080
https://pubmed.ncbi.nlm.nih.gov/15554875
https://pubmed.ncbi.nlm.nih.gov/15554875