Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lara Kern"'
Autor:
Linda Engström Ruud, Ferran Font-Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor-Deulofeu, Louise Mannerås-Holm, Alba Carreras, Barbara Becattini, Andreas Björefeldt, Eric Hanse, Henning Fenselau, Giovanni Solinas, Jens C. Brüning, Thomas F. Wunderlich, Fredrik Bäckhed, Johan Ruud
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113960- (2024)
Summary: GFRAL-expressing neurons actuate aversion and nausea, are targets for obesity treatment, and may mediate metformin effects by long-term GDF15-GFRAL agonism. Whether GFRAL+ neurons acutely regulate glucose and energy homeostasis is, however,
Externí odkaz:
https://doaj.org/article/aa3d323435254270b9519bdc32c22457
Autor:
Melanie J. Mittenbühler, Katarzyna Saedler, Hendrik Nolte, Lara Kern, Jun Zhou, Shu-Bing Qian, Lydia Meder, Roland T. Ullrich, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101085- (2020)
Objective: Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the develop
Externí odkaz:
https://doaj.org/article/94aae171be7140c5bfb4613a037c4e19
Autor:
Melanie J. Mittenbühler, Hans-Georg Sprenger, Sabine Gruber, Claudia M. Wunderlich, Lara Kern, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 122-133 (2018)
Objective: The current obesity pandemic represents a major health burden, given that it predisposes to the development of numerous obesity-associated disorders. The obesity-derived adipokines not only impair systemic insulin action but also increase
Externí odkaz:
https://doaj.org/article/774ace42901d46259223257b2842c3ed
Autor:
Danping Zheng, Gayatree Mohapatra, Lara Kern, Yiming He, Merav D. Shmueli, Rafael Valdés-Mas, Aleksandra A. Kolodziejczyk, Tomasz Próchnicki, Matilde B. Vasconcelos, Lena Schorr, Franziska Hertel, Ye Seul Lee, Miguel Camacho Rufino, Emmanuelle Ceddaha, Sandy Shimshy, Ryan James Hodgetts, Mally Dori-Bachash, Christian Kleimeyer, Kim Goldenberg, Melina Heinemann, Noa Stettner, Alon Harmelin, Hagit Shapiro, Jens Puschhof, Minhu Chen, Richard A. Flavell, Eicke Latz, Yifat Merbl, Suhaib K. Abdeen, Eran Elinav
Publikováno v:
Nature Immunology. 24:585-594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d29c2885e898343be67709812e43a1
https://doi.org/10.1038/s41590-023-01450-z
https://doi.org/10.1038/s41590-023-01450-z
Publikováno v:
Current Opinion in Microbiology. 63:158-171
The gut microbiota, a complex ecosystem of microorganisms of different kingdoms, impacts host physiology and disease. Within this ecosystem, inter-bacterial interactions and their impacts on microbiota community structure and the eukaryotic host rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8655c65e735b5768239da52b6073dd2
https://doi.org/10.1016/j.mib.2021.07.011
https://doi.org/10.1016/j.mib.2021.07.011
Publikováno v:
Current Opinion in Microbiology. 73:102287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f0d3a57cb17c8a6b477415e916065dc
https://doi.org/10.1016/j.mib.2023.102287
https://doi.org/10.1016/j.mib.2023.102287
Publikováno v:
Immunology
In this review, we summarize recent understandings on the assembly, activation and regulation patterns of the NLRP6 inflammasome, as well as its diverse impacts on tissue homeostasis and disease in multiple organs.
Summary The NOD‐like recepto
Summary The NOD‐like recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e42f0e0bb093bcb2e0575779d333db
https://doi.org/10.1111/imm.13293
https://doi.org/10.1111/imm.13293
Autor:
Sara Federici, Sharon Kredo-Russo, Rafael Valdés-Mas, Denise Kviatcovsky, Eyal Weinstock, Yulia Matiuhin, Yael Silberberg, Koji Atarashi, Munehiro Furuichi, Akihiko Oka, Bo Liu, Morine Fibelman, Iddo Nadav Weiner, Efrat Khabra, Nyssa Cullin, Noa Ben-Yishai, Dana Inbar, Hava Ben-David, Julian Nicenboim, Noga Kowalsman, Wolfgang Lieb, Edith Kario, Tal Cohen, Yael Friedman Geffen, Lior Zelcbuch, Ariel Cohen, Urania Rappo, Inbar Gahali-Sass, Myriam Golembo, Vered Lev, Mally Dori-Bachash, Hagit Shapiro, Claudia Moresi, Amanda Cuevas-Sierra, Gayatree Mohapatra, Lara Kern, Danping Zheng, Samuel Philip Nobs, Jotham Suez, Noa Stettner, Alon Harmelin, Naomi Zak, Sailaja Puttagunta, Merav Bassan, Kenya Honda, Harry Sokol, Corinna Bang, Andre Franke, Christoph Schramm, Nitsan Maharshak, Ryan Balfour Sartor, Rotem Sorek, Eran Elinav
Publikováno v:
Cell. 185:2879-2898.e24
Human gut commensals are increasingly suggested to impact non-communicable diseases, such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a daunting unmet challenge. In four geographically distinct IBD cohorts (n = 537),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c46ebb771e61c58f755b58dde8153e1
https://doi.org/10.1016/j.cell.2022.07.003
https://doi.org/10.1016/j.cell.2022.07.003
Autor:
Jun Zhou, Melanie J. Mittenbühler, Shu-Bing Qian, Hendrik Nolte, Lydia Meder, Roland T. Ullrich, Katarzyna Saedler, F. Thomas Wunderlich, Jens C. Brüning, Lara Kern
Publikováno v:
Molecular Metabolism
Mol Metab
Molecular Metabolism, Vol 42, Iss, Pp 101085-(2020)
Mol Metab
Molecular Metabolism, Vol 42, Iss, Pp 101085-(2020)
Objective Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725bb4594b3a7600077f3ceb39b83af6
http://europepmc.org/articles/PMC7560164
http://europepmc.org/articles/PMC7560164
Autor:
Anna Juliane Vesting, Claudia M. Wunderlich, Frank Wunderlich, Lara Kern, Melanie J. Mittenbühler, Anna Lena Ostermann
Publikováno v:
Cancers, Vol 11, Iss 1, p 24 (2018)
Cancers
Cancers
Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation. In particular, the recruitment and activation of immune cell subsets in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9b6f7e35f6017b62bbdaee60b38039
http://www.mdpi.com/2072-6694/11/1/24
http://www.mdpi.com/2072-6694/11/1/24