Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Lara K. Mahal"'
Autor:
Thirupathi Nuligonda, Gautam Kumar, Jason W. Wang, Dinithi Rajapaksha, Ismael A. Elayan, Ramiz Demir, Neil J. Meanwell, Sherrie F. Wang, Lara K. Mahal, Alex Brown, Michael W. Meanwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract C4ʹ-modified nucleoside analogues continue to attract global attention for their use in antiviral drug development and oligonucleotide-based therapeutics. However, current approaches to C4ʹ-modified nucleoside analogues still involve lengt
Externí odkaz:
https://doaj.org/article/d7aee5e037d04b6daf31add4ec8c4aae
Autor:
Daniel W. Heindel, Dania M. Figueroa Acosta, Marisa Goff, Clauvis Kunkeng Yengo, Muzafar Jan, Xiaomei Liu, Xiao-Hong Wang, Mariya I. Petrova, Mo Zhang, Manish Sagar, Phillip Barnette, Shilpi Pandey, Ann J. Hessell, Kun-Wei Chan, Xiang-Peng Kong, Benjamin K. Chen, Lara K. Mahal, Barbara A. Bensing, Catarina E. Hioe
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110390- (2024)
Summary: Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmiss
Externí odkaz:
https://doaj.org/article/e5305c3f335e45a9a5819c9e033eed91
Autor:
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Throug
Externí odkaz:
https://doaj.org/article/1b849c2f9a814c4e9507f12b5f5f0d43
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105163- (2022)
Summary: Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and functional significance of various types of glycosylation at cellular levels is hard to unravel experimentally. Multi-omics, single-cell measurements
Externí odkaz:
https://doaj.org/article/e9ca59b16a4f47679f3b402ec29b8e78
Autor:
Won-Min Song, Praveen Agrawal, Richard Von Itter, Barbara Fontanals-Cirera, Minghui Wang, Xianxiao Zhou, Lara K. Mahal, Eva Hernando, Bin Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
While the molecular profiling of melanoma progression has been extensively characterised by large-scale studies, there is still need for the comprehensive integration of such datasets. Here the authors construct predictive gene network models for pro
Externí odkaz:
https://doaj.org/article/34410138163b46d4b7214aefccddd28a
Publikováno v:
ACS Central Science. 8:1527-1536
Chemical biology has revealed the importance of sialic acids as a major signal in physiology and disease. The terminal modification α-2,6-sialic acid is controlled by the enzymes ST6GAL1 and ST6GAL2. Dysregulation of this glycan impacts immunologica
Autor:
Duong T. Bui, Zhixiong Li, Pavel I. Kitov, Ling Han, Elena N. Kitova, Marlène Fortier, Camille Fuselier, Philippine Granger Joly de Boissel, David Chatenet, Nicolas Doucet, Stephen M. Tompkins, Yves St-Pierre, Lara K. Mahal, John S. Klassen
Publikováno v:
ACS Central Science. 8:963-974
Electrospray ionization mass spectrometry (ESI-MS) is a powerful label-free assay for detecting noncovalent biomolecular complexes
Autor:
Chang Wang, Rebekah Honce, Mirella Salvatore, Daniela Chow, Davide Randazzo, Jianjun Yang, Nicholas M. Twells, Lara K. Mahal, Stacey Schultz-Cherry, Elodie Ghedin
Publikováno v:
Journal of Virology.
During replication, the influenza virus generates genetically defective viruses. These are found in natural infections as part of the virus population within the infected host.
Autor:
Rui Qin, Guanmin Meng, Smruti Pushalkar, Michael A. Carlock, Ted M. Ross, Christine Vogel, Lara K. Mahal
Publikováno v:
Journal of Proteome Research. 21:1974-1985
A key to improving vaccine design and vaccination strategy is to understand the mechanism behind the variation of vaccine response with host factors. Glycosylation, a critical modulator of immunity, has no clear role in determining vaccine responses.
Publikováno v:
Viruses, Vol 13, Iss 1, p 29 (2020)
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public health. Although primarily a respiratory illness, extrapulmonary manifestations
Externí odkaz:
https://doaj.org/article/22c1924fe2894fe2b1b729b0f65313a7