Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Lara K Mahal"'
Autor:
C. Kimberly Tsui, Nicholas Twells, Jenni Durieux, Emma Doan, Jacqueline Woo, Noosha Khosrojerdi, Janiya Brooks, Ayodeji Kulepa, Brant Webster, Lara K. Mahal, Andrew Dillin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Glycans play critical roles in cellular signaling and function. Unlike proteins, glycan structures are not templated from genetic sequences but synthesized by the concerted activity of many genes, making them historically challenging to stud
Externí odkaz:
https://doaj.org/article/13e08ddc06d04691824a24ec2e9cac04
Autor:
Thirupathi Nuligonda, Gautam Kumar, Jason W. Wang, Dinithi Rajapaksha, Ismael A. Elayan, Ramiz Demir, Neil J. Meanwell, Sherrie F. Wang, Lara K. Mahal, Alex Brown, Michael W. Meanwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract C4ʹ-modified nucleoside analogues continue to attract global attention for their use in antiviral drug development and oligonucleotide-based therapeutics. However, current approaches to C4ʹ-modified nucleoside analogues still involve lengt
Externí odkaz:
https://doaj.org/article/d7aee5e037d04b6daf31add4ec8c4aae
Autor:
Bernard J Moncla, Catherine A Chappell, Lara K Mahal, Brian M Debo, Leslie A Meyn, Sharon L Hillier
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127091 (2015)
The objective of this study was to evaluate the impact of hormonal status and bacterial vaginosis (BV) on the glycosidases present and glycosylation changes as assessed by lectin binding to cervicovaginal lavage constituents. Frozen cervicovaginal la
Externí odkaz:
https://doaj.org/article/3b915f33aae840de9c5fdfd5a98dc10f
Autor:
Linlin Wang, Sujeethraj Koppolu, Catherine Chappell, Bernard J Moncla, Sharon L Hillier, Lara K Mahal
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127021 (2015)
The cervicovaginal fluid (CVF) coating the vaginal epithelium is an important immunological mediator, providing a barrier to infection. Glycosylation of CVF proteins, such as mucins, IgG and S-IgA, plays a critical role in their immunological functio
Externí odkaz:
https://doaj.org/article/38c6fac079b44fcd9be2d2c9ff0cc96e
Autor:
Daniel W. Heindel, Dania M. Figueroa Acosta, Marisa Goff, Clauvis Kunkeng Yengo, Muzafar Jan, Xiaomei Liu, Xiao-Hong Wang, Mariya I. Petrova, Mo Zhang, Manish Sagar, Phillip Barnette, Shilpi Pandey, Ann J. Hessell, Kun-Wei Chan, Xiang-Peng Kong, Benjamin K. Chen, Lara K. Mahal, Barbara A. Bensing, Catarina E. Hioe
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110390- (2024)
Summary: Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmiss
Externí odkaz:
https://doaj.org/article/e5305c3f335e45a9a5819c9e033eed91
Autor:
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Throug
Externí odkaz:
https://doaj.org/article/1b849c2f9a814c4e9507f12b5f5f0d43
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105163- (2022)
Summary: Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and functional significance of various types of glycosylation at cellular levels is hard to unravel experimentally. Multi-omics, single-cell measurements
Externí odkaz:
https://doaj.org/article/e9ca59b16a4f47679f3b402ec29b8e78
Publikováno v:
ACS Central Science. 8:1527-1536
Chemical biology has revealed the importance of sialic acids as a major signal in physiology and disease. The terminal modification α-2,6-sialic acid is controlled by the enzymes ST6GAL1 and ST6GAL2. Dysregulation of this glycan impacts immunologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb353140c3cdbe92c7f95a2ebcc9b2fb
https://doi.org/10.1021/acscentsci.2c00748
https://doi.org/10.1021/acscentsci.2c00748
Autor:
Duong T. Bui, Zhixiong Li, Pavel I. Kitov, Ling Han, Elena N. Kitova, Marlène Fortier, Camille Fuselier, Philippine Granger Joly de Boissel, David Chatenet, Nicolas Doucet, Stephen M. Tompkins, Yves St-Pierre, Lara K. Mahal, John S. Klassen
Publikováno v:
ACS Central Science. 8:963-974
Electrospray ionization mass spectrometry (ESI-MS) is a powerful label-free assay for detecting noncovalent biomolecular complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0acd00c7086ce42b9c2199979d793a0
https://doi.org/10.1021/acscentsci.2c00215
https://doi.org/10.1021/acscentsci.2c00215
Autor:
Chang Wang, Rebekah Honce, Mirella Salvatore, Daniela Chow, Davide Randazzo, Jianjun Yang, Nicholas M. Twells, Lara K. Mahal, Stacey Schultz-Cherry, Elodie Ghedin
Publikováno v:
Journal of Virology.
During replication, the influenza virus generates genetically defective viruses. These are found in natural infections as part of the virus population within the infected host.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::938967a206fdacefa8664c122d51d1df
https://doi.org/10.1128/jvi.00493-23
https://doi.org/10.1128/jvi.00493-23