Zobrazeno 1 - 10 of 78 pro vyhledávání: '"Lara J. Gamble"'
1
Back to the basics of time-of-flight secondary ion mass spectrometry data analysis of bio-related samples. II. Data processing and display
Autor: Daniel J. Graham, Lara J. Gamble
Publikováno v: Biointerphases. 18
This is the second half of a two-part Tutorial on the basics of the time-of-flight secondary ion mass spectrometry (ToF-SIMS) analysis of bio-related samples. Part I of this Tutorial series covers planning for a ToF-SIMS experiment, preparing and shi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60072aa0371d59d42ccf51f5e7200dd4
https://doi.org/10.1116/6.0002633
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2
Back to the basics of time-of-flight secondary ion mass spectrometry of bio-related samples. I. Instrumentation and data collection
Autor: Daniel J. Graham, Lara J. Gamble
Publikováno v: Biointerphases. 18:021201
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is used widely throughout industrial and academic research due to the high information content of the chemically specific data it produces. Modern ToF-SIMS instruments can generate high mass r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6d5f66a76c20ee53c8a5617d5538102
https://doi.org/10.1116/6.0002477
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3
'Chip-on-a-Transwell' Devices for User-Friendly Control of the Microenvironment of Cultured Cells
Autor: Jonathan Cheng, Ross Boitano, Blake M. Bluestein, Philip R. Lindstedt, Lara J. Gamble, Albert Folch, Christopher G. Sip
Publikováno v: ACS Appl Bio Mater
We present microfabricated poly(dimethylsiloxane) templates assembled atop Transwell membranes (“Chip-on-a-Transwell”) for focal delivery of soluble reagents to cells. This modified Transwell operates based on area-selective diffusion of soluble
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad46010f3b2de481025abc8d82efc8b4
https://pubmed.ncbi.nlm.nih.gov/35021498
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4
Exploiting the Semidestructive Nature of Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry Imaging for Simultaneous Localization and Confident Lipid Annotations
Autor: Dušan Veličković, Carrie D. Nicora, Jennifer E. Kyle, Daniel J. Graham, Tina B. Angerer, Christopher R. Anderton, Lara J. Gamble
Publikováno v: Analytical Chemistry. 91:15073-15080
Lipids have been recognized as key players in cell signaling and disease. Information on their location and distribution within a biological system, under varying conditions, is necessary to understand the contributions of different lipid species to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17ca0e22f187aa8292fe4e211dfd0f18
https://doi.org/10.1021/acs.analchem.9b03763
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5
Time‐of‐flight secondary ion mass spectrometry three‐dimensional imaging of surface modifications in poly(caprolactone) scaffold pores
Autor: Lara J. Gamble, Michael J. Taylor, Daniel J. Graham
Publikováno v: J Biomed Mater Res A
Scaffolds composed of synthetic polymers such as poly(caprolactone) (PCL) are widely used for the support and repair of tissues in biomedicine. Pores are common features in scaffolds as they facilitate cell penetration. Various surface modifications
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d272acdd606c7f9e580fb83213e91a34
https://doi.org/10.1002/jbm.a.36729
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7
Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices
Autor: Alexander D. Malkin, William J. Federspiel, William R. Wagner, Lara J. Gamble, Xiguang Yang, Evan J. Lee, Yang Zhu, Sang-Ho Ye
Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 106:2681-2692
Respiratory assist devices, that utilize ∼2 m2 of hollow fiber membranes (HFMs) to achieve desired gas transfer rates, have been limited in their adoption due to such blood biocompatibility limitations. This study reports two techniques for the fun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1abf2cd424aae82b95506d48cba3f8e
https://doi.org/10.1002/jbm.b.34085
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9
Surfactants influence polymer nanoparticle fate within the brain
Autor: Andrea Joseph, Nuo Xu, Georges Motchoffo Simo, Daniel J. Graham, Norah Alhindi, Elizabeth Nance, Torahito Gao, Lara J. Gamble
Publikováno v: Biomaterials
Drug delivery to the brain is limited by poor penetration of pharmaceutical agents across the blood-brain barrier (BBB), within the brain parenchyma, and into specific cells of interest. Nanotechnology can overcome these barriers, but its ability to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f616abf4051c8847c99ad6fb05d6c00e
https://doi.org/10.1016/j.biomaterials.2021.121086
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10
An unsupervised MVA method to compare specific regions in human breast tumor tissue samples using ToF-SIMS
Autor: David M. Hockenbery, Fionnuala Morrish, Peggy L. Porter, Lara J. Gamble, Blake M. Bluestein, Jamie Guenthoer, Daniel J. Graham
Publikováno v: The Analyst. 141:1947-1957
Imaging time-of-flight secondary ion mass spectrometry (ToF-SIMS) and principal component analysis (PCA) were used to investigate two sets of pre- and post-chemotherapy human breast tumor tissue sections to characterize lipids associated with tumor m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa449480479681dbd6cae903a1d0a87
https://doi.org/10.1039/c5an02406d
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