Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lara García-Varela"'
Autor:
Silvia Cobelo-Gómez, Sofía Sánchez-Iglesias, Alberto Rábano, Ana Senra, Pablo Aguiar, Noemí Gómez-Lado, Lara García-Varela, Iván Burgueño-García, Laura Lampón-Fernández, Antía Fernández-Pombo, Everardo Josué Díaz-López, Teresa Prado-Moraña, Beatriz San Millán, David Araújo-Vilar
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106300- (2023)
Celia's encephalopathy or progressive encephalopathy with/without lipodystrophy is a neurodegenerative disease with a fatal prognosis in childhood. It is generally caused by the c.985C > T variant in the BSCL2 gene, leading to the skipping of exon 7
Externí odkaz:
https://doaj.org/article/0cf182812fae411f97db2870888c7d1d
Autor:
Sandra Díez-Villares, Lara García-Varela, Soraya Groba-de Antas, José Ramón Caeiro, Paula Carpintero-Fernandez, María D. Mayán, Pablo Aguiar, María de la Fuente
Publikováno v:
Journal of Controlled Release. 356:702-713
Autor:
Lara García-Varela, Rodrigo Moraga-Amaro, Gert Luurtsema, Aren van Waarde, Manuel Rodríguez-Pérez, Pablo Aguiar, Rudi Dierckx, Antía Custodia, Philip H. Elsinga, Tomás Sobrino, Nicola Antonio Colabufo
Publikováno v:
Molecular Pharmaceutics
Molecular pharmaceutics, 18(8), 3073-3085. AMER CHEMICAL SOC INC
Molecular pharmaceutics, 18(8), 3073-3085. AMER CHEMICAL SOC INC
P-Glycoprotein (P-gp) is an efflux pump located at the blood-brain barrier (BBB) that contributes to the protection of the central nervous system by transporting neurotoxic compounds out of the brain. A decline in P-gp function has been related to th
Autor:
Tetsuro Tago, Nicola Antonio Colabufo, Rudi Dierckx, Shingo Nishiyama, David Vállez García, Hideo Tsukada, Gert Luurtsema, Takeharu Kakiuchi, Aren van Waarde, Ronald Boellaard, Philip H. Elsinga, Hiroyuki Ohba, Lara García-Varela, Jun Toyohara
Publikováno v:
García-Varela, L, García, D V L, Kakiuchi, T, Ohba, H, Nishiyama, S, Tago, T, Elsinga, P H, Tsukada, H, Colabufo, N A, Dierckx, R A J O, van Waarde, A, Toyohara, J, Boellaard, R & Luurtsema, G 2021, ' Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates ', Molecular Pharmaceutics, vol. 18, no. 1, pp. 416-428 . https://doi.org/10.1021/acs.molpharmaceut.0c01014
Molecular Pharmaceutics, 18(1), 416-428. American Chemical Society
Molecular pharmaceutics, 18(1), 416-428. AMER CHEMICAL SOC INC
Molecular Pharmaceutics, 18(1), 416-428. American Chemical Society
Molecular pharmaceutics, 18(1), 416-428. AMER CHEMICAL SOC INC
(R)-[(11)C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Several studies have evaluated the pharmacokinetics of (R)-[(11)C]verapamil in rats and humans under differen
Autor:
Álvaro Ruibal, Adrián Posado-Fernández, Santiago Medín-Aguerre, Lara García-Varela, Francisco Campos, Ramón Iglesias-Rey, Tomás Sobrino, Pablo del Pino, Lucía Díaz-Platas, Esteban López-Arias, Juan Pardo-Montero, Pablo Aguiar, Anxo Fernández-Ferreiro, Noemí Gómez-Lado, Manuel Rodríguez-Pérez, José Castillo
Publikováno v:
Molecular Pharmaceutics. 17:4667-4675
Intracerebral hemorrhage (ICH), being the most severe cerebrovascular disease, accounts for 10-15% of all strokes. Hematoma expansion is one of the most important factors associated with poor outcome in intracerebral hemorrhage (ICH). Several studies
Autor:
Tetsuro Tago, Jun Toyohara, Rudi Dierckx, Norihiro Harada, Philip H. Elsinga, Hideo Tsukada, David Vállez García, Aren van Waarde, Ronald Boellaard, Lara García-Varela, Hiroyuki Ohba, Wejdan M. Arif, Takeharu Kakiuchi, Nicola Antonio Colabufo, Gert Luurtsema
Publikováno v:
García-Varela, L, Arif, W M, Vállez García, D, Kakiuchi, T, Ohba, H, Harada, N, Tago, T, Elsinga, P H, Tsukada, H, Colabufo, N A, Dierckx, R A J O, van Waarde, A, Toyohara, J, Boellaard, R & Luurtsema, G 2020, ' Pharmacokinetic Modeling of [18F]MC225 for Quantification of the P-Glycoprotein Function at the Blood-Brain Barrier in Non-Human Primates with PET ', Molecular Pharmaceutics, vol. 17, no. 9, pp. 3477-3486 . https://doi.org/10.1021/acs.molpharmaceut.0c00514
Molecular Pharmaceutics, 17(9), 3477-3486. American Chemical Society
Molecular pharmaceutics, 17(9), 3477-3486. AMER CHEMICAL SOC INC
Molecular Pharmaceutics
Molecular Pharmaceutics, 17(9), 3477-3486. American Chemical Society
Molecular pharmaceutics, 17(9), 3477-3486. AMER CHEMICAL SOC INC
Molecular Pharmaceutics
[18F]MC225 has been developed as a weak substrate of P-glycoprotein (P-gp) aimed to measure changes in the P-gp function at the blood-brain barrier with positron emission tomography. This study evaluates [18F]MC225 kinetics in non-human primates and
Autor:
Hiroyuki Ohba, Nicola Antonio Colabufo, Takeharu Kakiuchi, Jun Toyohara, Rudi Dierckx, Gert Luurtsema, Pablo Aguiar, Shingo Nishiyama, David Vállez García, Hideo Tsukada, Lara García-Varela, Tetsuro Tago, Philip H. Elsinga, Norihiro Harada, Aren van Waarde, Ronald Boellaard
Publikováno v:
García-Varela, L, Vállez García, D, Aguiar, P, Kakiuchi, T, Ohba, H, Harada, N, Nishiyama, S, Tago, T, Elsinga, P H, Tsukada, H, Colabufo, N A, Dierckx, R A J O, van Waarde, A, Toyohara, J, Boellaard, R & Luurtsema, G 2021, ' Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 48, no. 13, pp. 4307-4317 . https://doi.org/10.1007/s00259-021-05411-2
European Journal of Nuclear Medicine and Molecular Imaging, 48(13), 4307-4317. SPRINGER
European Journal of Nuclear Medicine and Molecular Imaging, 48(13), 4307-4317. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 48(13), 4307-4317. SPRINGER
European Journal of Nuclear Medicine and Molecular Imaging, 48(13), 4307-4317. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging
Purpose P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of interest to monitor the P-gp function in vivo using PET. (R)-[11C]verapamil is considered the gold standard tracer to measure the P-gp function; however, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b63c5f344f3cde0aa014bc35649372
https://research.vumc.nl/en/publications/b8ebe2f8-5a66-4b3c-81ce-cb38bb6da027
https://research.vumc.nl/en/publications/b8ebe2f8-5a66-4b3c-81ce-cb38bb6da027
Autor:
Rudi Dierckx, Lara García-Varela, Ton J. Visser, Khaled A. Attia, Chantal Kwizera, Gert Luurtsema, John Carlo Sembrano, Inês Antunes, Olivier Jacquet, Philip H. Elsinga
Publikováno v:
EJNMMI Radiopharmacy and Chemistry
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-13 (2021)
EJNMMI Radiopharmacy and Chemistry, 6(1), 1-13. Springer
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-13 (2021)
EJNMMI Radiopharmacy and Chemistry, 6(1), 1-13. Springer
Background [18F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to different factors, for instance, decreased P-gp function has been described in patients with Alzheim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9b1b344c6173c1407265ac7d6d8cc1
https://doi.org/10.21203/rs.3.rs-377973/v1
https://doi.org/10.21203/rs.3.rs-377973/v1
Autor:
Lara, García-Varela, David Vállez, García, Takeharu, Kakiuchi, Hiroyuki, Ohba, Shingo, Nishiyama, Tetsuro, Tago, Philip H, Elsinga, Hideo, Tsukada, Nicola A, Colabufo, Rudi A J O, Dierckx, Aren, van Waarde, Jun, Toyohara, Ronald, Boellaard, Gert, Luurtsema
Publikováno v:
Molecular Pharmaceutics
(R)-[11C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) function at the blood–brain barrier (BBB). Several studies have evaluated the pharmacokinetics of (R)-[11C]verapamil in rats and humans under different
Autor:
Aren van Waarde, Nicola Antonio Colabufo, Gert Luurtsema, Albert D. Windhorst, Lara García-Varela, Philip H. Elsinga, Heli Savolainen, Pascalle Mossel, Marcel Benadiba
Publikováno v:
García-Varela, L, Mossel, P, Benadiba, M, Savolainen, H, Colabufo, N A, Windhorst, A D, Elsinga, P, van Waarde, A & Luurtsema, G 2020, PET imaging of ABC transporters at the blood-brain barrier . in PET and SPECT of Neurobiological Systems . PET and SPECT of Neurobiological Systems, Springer International Publishing, pp. 809-850 . https://doi.org/10.1007/978-3-030-53176-8_22
PET and SPECT of Neurobiological Systems ISBN: 9783030531751
University of Groningen
PET and SPECT of Neurobiological Systems, 809-850
STARTPAGE=809;ENDPAGE=850;TITLE=PET and SPECT of Neurobiological Systems
PET and SPECT of Neurobiological Systems ISBN: 9783030531751
University of Groningen
PET and SPECT of Neurobiological Systems, 809-850
STARTPAGE=809;ENDPAGE=850;TITLE=PET and SPECT of Neurobiological Systems
The function of ATP-binding cassette (ABC) transporters at the blood-brain barrier (BBB) is to protect the brain from toxic compounds. Additionally, they play a crucial role in the onset and progression of several central nervous system (CNS) disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f15f1a87742e274f3d1c29ced6878
https://research.vumc.nl/en/publications/077870fa-e4a6-4337-8229-d7ed7d23b0e7
https://research.vumc.nl/en/publications/077870fa-e4a6-4337-8229-d7ed7d23b0e7