Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lara G. Merino"'
Autor:
Keyi Geng, Lara G. Merino, Raül G. Veiga, Christian Sommerauer, Janine Epperlein, Eva K. Brinkman, Claudia Kutter
The CRISPR-Cas9 system is a powerful tool for studying gene functions and has tremendous potential for disease treatment. However, precise genome editing requires thorough assessments to minimize unintended on- and off-target effects. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1e325362adc4d8024e1a4a24b670427
https://doi.org/10.1101/2023.04.05.535680
https://doi.org/10.1101/2023.04.05.535680
Autor:
Keyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, Yerma P. Sanchez, Jonas Nørskov Søndergaard, Robert J. White, Claudia Kutter
Publikováno v:
Genome research. 32(10)
The CRISPR-Cas9 system is widely used to permanently delete genomic regions via dual guide RNAs. Genomic rearrangements induced by CRISPR-Cas9 can occur, but continuous technical developments make it possible to characterize complex on-target effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0959d5f4abe066c7ef5419c92a8b4d
https://pubmed.ncbi.nlm.nih.gov/36180232
https://pubmed.ncbi.nlm.nih.gov/36180232
Autor:
Lara G. Merino, Anne Simonsen, Shanshan Xu, Florian A. Salomons, Maria E. Gierisch, Laura K. Herzog, Martin Haraldsson, Hanna Uvell, Nico P. Dantuma, Anna-Lena Gustavsson, Henriette Stoy, Michaela Vallin, Tatiana A. Giovannucci, Weixing Qian, Alf Håkon Lystad
Publikováno v:
Autophagy. 18(7)
The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of aberrant proteins, these complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfeea9fa181bca01eca342162156b524
https://pubmed.ncbi.nlm.nih.gov/34740308
https://pubmed.ncbi.nlm.nih.gov/34740308
Autor:
Keyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, Yerma P. Sanchez, Jonas Nørskov Søndergaard, Robert J. White, Claudia Kutter
The CRISPR/Cas9 system is widely used to permanently delete genomic regions by inducing double-strand breaks via dual guide RNAs. However, on-target consequences of Cas9 deletion events have yet to be fully investigated. To characterize Cas9-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e164cf6000318ae838e69b1870186d4
https://doi.org/10.1101/2021.07.01.450727
https://doi.org/10.1101/2021.07.01.450727