Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lara E. Terry"'
Autor:
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here authors report cryo-EM structures of IP3R1 which provide atomic details of IP3, Ca2+ and ATP binding. Molecular motions of key domains and sidechains were found to regulate ligand binding and gating, which are validated by functional assays.
Externí odkaz:
https://doaj.org/article/19978619640c40e4bd70b573581c08b9
Autor:
Lara E. Terry, Vikas Arige, Julika Neumann, Amanda M. Wahl, Taylor R. Knebel, James W. Chaffer, Sundeep Malik, Adrian Liston, Stephanie Humblet-Baron, Geert Bultynck, David I. Yule
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105523- (2022)
Summary: Mutations in all subtypes of the inositol 1,4,5-trisphosphate receptor Ca2+ release channel are associated with human diseases. In this report, we investigated the functionality of three neuropathy-associated missense mutations in IP3R3 (V61
Externí odkaz:
https://doaj.org/article/8a4e8aa047b34215abf1d60d404fecd4
Autor:
Vikas Arige, Lara E. Terry, Larry E. Wagner, Sundeep Malik, Mariah R. Baker, Guizhen Fan, Suresh K. Joseph, Irina I. Serysheva, David I. Yule
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(39)
Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca 2+ ) signals in response to various external cues. Notably, IP 3 R channel activity is determine
Autor:
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva
Inositol-1,4,5-trisphosphate receptors (IP3Rs) are activated by IP3 and Ca2+ and their gating is regulated by various intracellular messengers that finely tune the channel activity. Here, using single particle cryo-EM analysis we determined 3D struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac020b81808b0a7919b5bffd9befaf0b
https://doi.org/10.1101/2022.05.27.493711
https://doi.org/10.1101/2022.05.27.493711
Publikováno v:
The Journal of Biological Chemistry
The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP3Rs have been increasingly associated with many de
Autor:
Julika, Neumann, Erika, Van Nieuwenhove, Lara E, Terry, Frederik, Staels, Taylor R, Knebel, Kirsten, Welkenhuyzen, Kourosh, Ahmadzadeh, Mariah R, Baker, Margaux, Gerbaux, Mathijs, Willemsen, John S, Barber, Irina I, Serysheva, Liesbeth, De Waele, François, Vermeulen, Susan, Schlenner, Isabelle, Meyts, David I, Yule, Geert, Bultynck, Rik, Schrijvers, Stephanie, Humblet-Baron, Adrian, Liston
Publikováno v:
Cellularmolecular immunology. 20(1)
Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca
Autor:
Vikas Arige, Lara E. Terry, Larry E. Wagner, Mariah R. Baker, Guizhen Fan, Irina I. Serysheva, David I. Yule
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca2+) signals in response to various external cues. Notably, IP3R channel activity is determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f50fdaa4276d6b38f43b9b642685124
https://doi.org/10.1101/2022.03.07.482538
https://doi.org/10.1101/2022.03.07.482538
Autor:
Moaz Ahmad, Hwei Ling Ong, Hassan Saadi, Ga-Yeon Son, Zahra Shokatian, Lara E. Terry, Mohamed Trebak, David I. Yule, Indu Ambudkar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance STIM proteins sense decreases in [Ca2+]ER and cluster in endoplasmic reticulum (ER)–plasma membrane (PM) junctions where they recruit and activate Orai1. While STIM1 clustering requires substantial [Ca2+]ER decrease, STIM2 displays pre
Autor:
Lara E. Terry, Vikas Arige, Julika Neumann, Amanda Wahl, Taylor R. Knebel, James W. Chaffer, Sundeep Malik, Adrian Liston, S Humblet-Baron, Geert Bulytnck, David Yule
Publikováno v:
SSRN Electronic Journal.
Autor:
Julika Neumann, Erika Van Nieuwenhove, Lara E. Terry, Frederik Staels, Taylor R. Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R. Baker, Margaux Gerbaux, Mathijs Willemsen, John S. Barber, Irina I. Serysheva, Liesbeth De Waele, François Vermeulen, Susan Schlenner, Isabelle Meyts, David I. Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
Publikováno v:
Cellular & Molecular Immunology. 20:114-114