Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women

Autor: Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa V. Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming-Halverson, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa A. Troester, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Peter N. Fiorica, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Lawrence H. Kushi, Gabriela Torres-Mejia, Donglei Hu, Laura Fejerman, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Dale P. Sandler, Jack A. Taylor, Katie M. O’Brien, Cari M. Kitahara, Adeyinka G. Falusi, Chinedum Babalola, Joel Yarney, Baffour Awuah, Beatrice Addai-Wiafe, The GBHS Study Team, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David V. Conti, Elad Ziv, Olufunmilayo I. Olopade, Montserrat Garcia-Closas, Julie R. Palmer, Christopher A. Haiman, Dezheng Huo

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with brea

Externí odkaz: https://doaj.org/article/6f0e5304a68d47149e5deb98e9b77d0a

High dimensional model representation of log likelihood ratio: binary classification with SNP data

Autor: Ali Foroughi pour, Maciej Pietrzak, Lara E. Sucheston-Campbell, Ezgi Karaesmen, Lori A. Dalton, Grzegorz A. Rempała

Publikováno v: BMC Medical Genomics, Vol 13, Iss S9, Pp 1-22 (2020)

Abstract Background Developing binary classification rules based on SNP observations has been a major challenge for many modern bioinformatics applications, e.g., predicting risk of future disease events in complex conditions such as cancer. Small-sa

Externí odkaz: https://doaj.org/article/d6da352384784b5f8411ddfc07adac08

Multiple functional variants in the IL1RL1 region are pretransplant markers for risk of GVHD and infection deaths

Autor: Ezgi Karaesmen, Theresa Hahn, Alexander James Dile, Abbas A. Rizvi, Junke Wang, Tao Wang, Michael D. Haagenson, Leah Preus, Qianqian Zhu, Qian Liu, Li Yan, Song Liu, Christopher A. Haiman, Daniel Stram, Loreall Pooler, Xin Sheng, David Van Den Berg, Guy Brock, Amy Webb, Philip L. McCarthy, Marcelo C. Pasquini, Stephen R. Spellman, Stephanie J. Lee, Sophie Paczesny, Lara E. Sucheston-Campbell

Publikováno v: Blood Advances, Vol 3, Iss 16, Pp 2512-2524 (2019)

Abstract: Graft-versus-host disease (GVHD) and infections are the 2 main causes of death without relapse after allogeneic hematopoietic cell transplantation (HCT). Elevated soluble serum simulation-2 (sST2), the product of IL1RL1 in plasma/serum post

Externí odkaz: https://doaj.org/article/b5a5fbd3681545f893974314a2ebe8d0

African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Autor: Manjunath Siddappa, Shahid Hussain, Sajad A. Wani, Jason White, Hancong Tang, Jaimie S. Gray, Hedieh Jafari, Hsu-Chang Wu, Mark D. Long, Isra Elhussin, Balasubramanyam Karanam, Honghe Wang, Rebecca Morgan, Gary Hardiman, Isaacson B. Adelani, Solomon O. Rotimi, Adam R. Murphy, Larisa Nonn, Melissa B. Davis, Rick A. Kittles, Chanita Hughes Halbert, Lara E. Sucheston-Campbell, Clayton Yates, Moray J. Campbell

Publikováno v: Siddappa, M, Hussain, S, Wani, S A, White, J, Tang, H, Gray, J S, Jafari, H, Wu, H-C, Long, M D, Elhussin, I, Karanam, B, Wang, H, Morgan, R, Hardiman, G, Adelani, I B, Rotimi, S O, Murphy, A R, Nonn, L, Davis, M B, Kittles, R A, Hughes Halbert, C, Sucheston-Campbell, L E, Yates, C & Campbell, M J 2023, ' African American prostate cancer displays quantitatively distinct vitamin D receptor cistrome-transcriptome relationships regulated by BAZ1A ', Cancer Research Communications, vol. 3, no. 4, pp. 621-639 . https://doi.org/10.1158/2767-9764.crc-22-0389

African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses in European American (EA) and AA prostate ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632bca3c74f2fc49d513601216c48c53
https://doi.org/10.1158/2767-9764.crc-22-0389

Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

Autor: Jennifer M. Mongiovi, Gary R. Zirpoli, Rikki Cannioto, Lara E. Sucheston-Campbell, Dawn L. Hershman, Joseph M. Unger, Halle C. F. Moore, James A. Stewart, Claudine Isaacs, Timothy J. Hobday, Muhammad Salim, Gabriel N. Hortobagyi, Julie R. Gralow, G. Thomas Budd, Kathy S. Albain, Christine B. Ambrosone, Susan E. McCann

Publikováno v: Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)

Abstract Background The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The pr

Externí odkaz: https://doaj.org/article/9d0a7a1284e54998b733c15ed2ca4e29