Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer

Autor: Rich Williams, Debayan Mukherjee, Mehjabin Patel, Sharon L. Eddie, Charles M. Haughey, Rebecca E Steele, Timothy M Illidge, Adam Pickard, Simon S. McDade, Niamh E. Buckley, Suneil Jain, Amy Popple, Pedro Oliveira, Jamie Honeychurch, Lara Dura-Perez, Ian G. Mills, Paul B. Mullan

Publikováno v: Cancers, Vol 12, Iss 2804, p 2804 (2020)
Cancers
Haughey, C M, Mukherjee, D, Steele, R E, Popple, A, Dura-Perez, L, Pickard, A, Patel, M, Jain, S, Mullan, P B, Williams, R, Oliveira, P, Buckley, N E, Honeychurch, J, S McDade, S, Illidge, T, Mills, I G & Eddie, S L 2020, ' Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer ', Cancers, vol. 12, no. 10 . https://doi.org/10.3390/cancers12102804
Haughey, C M, Mukherjee, D, Steele, R E, Popple, A, Dura-Perez, L, Pickard, A, Patel, M, Jain, S, Mullan, P B, Williams, R, Oliveira, P, Buckley, N E, Honeychurch, J, S McDade, S, Illidge, T, Mills, I G & Eddie, S L 2020, ' Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer ', Cancers, vol. 12, no. 10, 2804 . https://doi.org/10.3390/cancers12102804
Volume 12
Issue 10

The prostate cancer (PCa) field lacks clinically relevant, syngeneic mouse models which retain the tumour microenvironment observed in PCa patients. This study establishes a cell line from prostate tumour tissue derived from the Pten&minus
/&min

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b355170b6cb033b993c30da88a5875
https://www.mdpi.com/2072-6694/12/10/2804

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA

Autor: Paul C. Boutros, Lara Dura-Perez, Ross G Murphy, Jessica Ray, Michelle R. Downes, Jouhyun Jeon, Christianne Hoey, Suneil Jain, Nuala McCabe, Ian G. Mills, Charles M. Haughey, Stanley K. Liu

Publikováno v: Ray, J, Haughey, C, Hoey, C, Jeon, J, Murphy, R, Dura-Perez, L, McCabe, N, Downes, M, Jain, S, Boutros, P C, Mills, I G & Liu, S K 2019, ' miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA ', Cancer Letters . https://doi.org/10.1016/j.canlet.2019.12.025

Radiation therapy is a common treatment for prostate cancer, however recurrence remains a problem. MicroRNA expression is altered in prostate cancer and may promote therapy resistance. Through bioinformatic analyses of TCGA and CPC-GENE patient cohor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985694b4fb2b3cd803afd4edd84db309
http://ora.ox.ac.uk/objects/uuid:

Platinum based chemotherapy selects for PDGFRα dependent angiogenesis

Autor: Alan W. Stitt, Laura A. Knight, Charlie Gourley, Richard D. Kennedy, Lara Dura Perez, Christopher Steele, Reinhold J. Medina, W. Glenn McCluggage, Richard H. Wilson, Aya El-Helali, Caroline O. Michie, Christina L. O'Neill, Stephen McQuaid, Andrena McCavigan, Nuala McCabe, Denis Paul Harkin, Jacqueline James

Publikováno v: Journal of Clinical Oncology. 36:5578-5578

5578Background: Patients with High Grade Serous Ovarian Cancer (HGSOC) initially respond to SOC platinum based treatment but most will eventually relapse with platinum resistant disease. Angiogenes...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a1f2274d031ca8d238e731fab81e2bf
https://doi.org/10.1200/jco.2018.36.15_suppl.5578

Abstract 776: Acquired platinum resistance enhances tumour angiogenesis through activation of vascular mimicry

Autor: Richard Wilson, Lara Dura Perez, Nuala McCabe, Naomi Dickson, Aya El Helali, Richard D. Kennedy, Denis Paul Harkin

Publikováno v: Cancer Research. 77:776-776

Introduction: Platinum resistant High Grade Serous Ovarian Cancer (HGSOC) has a poor outcome with limited treatment options. Angiogenesis is a key pathological feature of ovarian cancer and anti-angiogenics have dominated the field of drug developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a543ce1af3423e232da2f93b1569c84
https://doi.org/10.1158/1538-7445.am2017-776