Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lara Djakovic"'
Autor:
Lara Djakovic, Thomas Hennig, Katharina Reinisch, Andrea Milić, Adam W. Whisnant, Katharina Wolf, Elena Weiß, Tobias Haas, Arnhild Grothey, Christopher S. Jürges, Michael Kluge, Elmar Wolf, Florian Erhard, Caroline C. Friedel, Lars Dölken
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin acce
Externí odkaz:
https://doaj.org/article/88c94da7658643c8abd946d207f3dd82
Autor:
Adam W. Whisnant, Christopher S. Jürges, Thomas Hennig, Emanuel Wyler, Bhupesh Prusty, Andrzej J. Rutkowski, Anne L’hernault, Lara Djakovic, Margarete Göbel, Kristina Döring, Jennifer Menegatti, Robin Antrobus, Nicholas J. Matheson, Florian W. H. Künzig, Guido Mastrobuoni, Chris Bielow, Stefan Kempa, Chunguang Liang, Thomas Dandekar, Ralf Zimmer, Markus Landthaler, Friedrich Grässer, Paul J. Lehner, Caroline C. Friedel, Florian Erhard, Lars Dölken
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, using computational integration of multi-omics data, the authors provide a detailed transcriptome and translatome of herpes simplex virus 1 (HSV-1), including previously unidentified ORFs and N-terminal extensions. The study also provides a HSV
Externí odkaz:
https://doaj.org/article/2bc69e036d254f1f89647997e0dbd0b2
Autor:
Marie-Sophie Friedl, Lara Djakovic, Michael Kluge, Thomas Hennig, Adam W. Whisnant, Simone Backes, Lars Dölken, Caroline C. Friedel
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
The herpes simplex virus 1 (HSV-1) virion host shut-off (vhs) protein cleaves both cellular and viral mRNAs by a translation-initiation-dependent mechanism, which should spare circular RNAs (circRNAs). Here, we show that vhs-mediated degradation of l
Externí odkaz:
https://doaj.org/article/b3be6ae9e2074d9f965eef71a88bde10
Autor:
Xiuye Wang, Liang Liu, Adam W Whisnant, Thomas Hennig, Lara Djakovic, Nabila Haque, Cindy Bach, Rozanne M Sandri-Goldin, Florian Erhard, Caroline C Friedel, Lars Dölken, Yongsheng Shi
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009263 (2021)
Eukaryotic gene expression is extensively regulated by cellular stress and pathogen infections. We have previously shown that herpes simplex virus 1 (HSV-1) and several cellular stresses cause widespread disruption of transcription termination (DoTT)
Externí odkaz:
https://doaj.org/article/2e679acc20f04b73be31b6e85ae139cc
Publikováno v:
Viruses, Vol 13, Iss 9, p 1836 (2021)
During lytic infection, herpes simplex virus (HSV) 1 induces a rapid shutoff of host RNA synthesis while redirecting transcriptional machinery to viral genes. In addition to being a major human pathogen, there is burgeoning clinical interest in HSV a
Externí odkaz:
https://doaj.org/article/cab49472081b4c6d920e0fd433a5a4f1
Autor:
Thomas Hennig, Marco Michalski, Andrzej J Rutkowski, Lara Djakovic, Adam W Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A P Baptista, Anne L'Hernault, Florian Erhard, Lars Dölken, Caroline C Friedel
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006954 (2018)
Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination (DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, cellular stress responses lead to gene-specific transcription d
Externí odkaz:
https://doaj.org/article/0b734ce74d4b448b8f8c6a89158cb1cf
Autor:
Elena Weiß, Thomas Hennig, Pilar Graßl, Lara Djakovic, Adam W. Whisnant, Christopher S. Jürges, Franziska Koller, Michael Kluge, Florian Erhard, Lars Dölken, Caroline C. Friedel
Publikováno v:
Journal of Virology. 97
This study provides a genome-wide analysis of changes in promoter-proximal polymerase II (Pol II) pausing on host genes induced by HSV-1 infection. It shows that standard measures of pausing, i.e., pausing indices, do not properly capture the complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95824fa5a9e093b9919761a44ba7b8f
https://doi.org/10.1128/jvi.00381-23
https://doi.org/10.1128/jvi.00381-23
Autor:
Elena Weiß, Thomas Hennig, Pilar Graßl, Lara Djakovic, Adam W. Whisnant, Christopher S. Jürges, Franziska Koller, Michael Kluge, Florian Erhard, Lars Dölken, Caroline C. Friedel
Herpes simplex virus 1 (HSV-1) infection exerts a profound shut-off of host gene expression at multiple levels. Recently, HSV-1 infection was reported to also impact promoter-proximal RNA Polymerase II (Pol II) pausing, a key step in the eukaryotic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b226763a037d5615b903f7f27c8503a
https://doi.org/10.1101/2022.09.28.509911
https://doi.org/10.1101/2022.09.28.509911
Autor:
Andrea Milic, Katharina Wolf, Elmar Wolf, Katharina Reinisch, Caroline C. Friedel, Michael Kluge, Christopher Juerges, Lars Dölken, Lara Djakovic, Florian Erhard, Thomas Hennig, Adam W. Whisnant, Elena Weiß, Arnhild Grothey, Tobias Haas
Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin accessibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16a3f251e10f836d52cdcf1320c40331
https://doi.org/10.21203/rs.3.rs-998249/v1
https://doi.org/10.21203/rs.3.rs-998249/v1
Autor:
Paul J. Lehner, Caroline C. Friedel, Andrea Milic, Lara Djakovic, Florian Erhard, Lars Dölken, Thomas Hennig, Adam W. Whisnant, Arnhild Grothey, Michael Kluge, Sascha Sauer, Marie-Sophie Friedl, Nicholas J Matheson, Somesh Sai, Bhupesh K. Prusty, James C Williamson, Andrzej J. Rutkowski, Ramon Vidal
Publikováno v:
Journal of virology
United States
Journal of Virology
United States
Journal of Virology
The HSV-1 virion host shutoff (vhs) protein efficiently cleaves both host and viral mRNAs in a translation-dependent manner. In this study, we model and quantify changes in vhs activity, as well as virus-induced global loss of host transcriptional ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ba98536a09e2bba57a307c57ff18e5
https://hdl.handle.net/10033/622606
https://hdl.handle.net/10033/622606