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of 4
pro vyhledávání: '"Lara D. Penn"'
Autor:
Francesca E. Wright, Brian W. Pack, Lara D. Penn, Gregory S. Gorman, Teresa R. Henry, Jason R. Conerty
Publikováno v:
The AAPS journal. 18(6)
Non-clinical dose formulations (also known as pre-clinical or GLP formulations) play a key role in early drug development. These formulations are used to introduce active pharmaceutical ingredients (APIs) into test organisms for both pharmacokinetic
Autor:
Ziqiang Wang, Hongliang Cai, Douglas Burdette, Narayanan Surendran, Anita Reddy, Lara D Penn, Charles J. Stankovic, Muhammed F. Hashim
Publikováno v:
International Journal of Pharmaceutics. 335:63-69
An inhibition assay to assess the potential for chiral inversion of compounds was developed using R(-)-ibuprofen as the probe substrate. Inhibition of the chiral inversion of R(-)-ibuprofen by structurally similar compounds in cyropreserved rat hepat
Publikováno v:
Analytical Chemistry. 76:1761-1767
Compound extraction from biological tissue often presents a challenge for the bioanalytical chemist. Labor-intensive homogenization or sonication of whole or powdered tissue is performed before compounds can be extracted and analyzed. Enzymatic diges
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 25:569-576
A liquid chromatographic/mass spectrometric (LC/MS/MS) method to quantitate an anti-cancer drug in human plasma was validated. The method has proven suitable for routine quantitation of the experimental anti-cancer compound at concentrations from 1 t