Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lara C. Czabaniuk"'
Autor:
Laura A. McAllister, Michael Aaron Brodney, Jane M. Withka, Jiangli Yan, Thomas N. O'Connell, Laurence Philippe, Kevin Ogilvie, Lara C. Czabaniuk, Matthew Frank Brown, Guoyun Bai, Adam M. Gilbert, Daniel P. Uccello, Erik Alphie Lachapelle, Chao Li, Michael J. Shapiro, Christopher Ryan Butler, Romelia Salomon-Ferrer, Jeremy T. Starr
Publikováno v:
ACS Med Chem Lett
[Image: see text] The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61495fbd8a53cc5202ef7fb9ae427eaa
https://europepmc.org/articles/PMC8521649/
https://europepmc.org/articles/PMC8521649/
Autor:
Suman Luthra, Graham M. West, Jeremy T. Starr, Matthew Frank Brown, Matthew F. Calabrese, Jinshan Chen, Hongyao Zhu, Xiayang Qiu, Daniel P. Uccello, Matthew Merrill Hayward, Jeanne S. Chang, Jotham Wadsworth Coe, Kathleen A. Farley, Kris A. Borzilleri, Mark C. Noe, Justin I. Montgomery, Adam M. Gilbert, Veerabahu Shanmugasundaram, Lara C. Czabaniuk, Robert M. Oliver, Carmen N. Garcia-Irrizary, Brandon P. Schuff, Chuong Nguyen, Yingrong Xu, James Schiemer, Jaymin C. Shah, Xidong Feng, Mark Niosi, Jennifer A. Young, WeiDong Ding, Ayman El-Kattan, Adelajda Zorba, James F. Smith
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They present an exciting opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf434de63be490efb6416cf59a222839
https://europepmc.org/articles/PMC6077745/
https://europepmc.org/articles/PMC6077745/
Autor:
Lara C. Czabaniuk, Barry M. Trost
Publikováno v:
Angewandte Chemie. 126:2868-2895
Die Koordination von Ubergangsmetallen an organische Einheiten kann zu Komplexen mit faszinierenden und unerwarteten Bindungsmustern fuhren. Untersuchungen von Benzylmetall-Komplexen haben die Moglichkeit einer η3-Koordination ergeben, die zu einem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0639d5b68d8b343ff15c952d690cf60
https://doi.org/10.1002/ange.201305972
https://doi.org/10.1002/ange.201305972
Autor:
Barry M. Trost, Lara C. Czabaniuk
Publikováno v:
Angewandte Chemie International Edition. 53:2826-2851
The coordination of transition metals to organic fragments can yield complexes with fascinating and unexpected binding patterns. The study of metal-benzyl complexes has demonstrated the feasibility of η(3)-coordination, which results in a dearomatiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12373de66e3ec37e95f024fb71b5bae0
https://doi.org/10.1002/anie.201305972
https://doi.org/10.1002/anie.201305972
Autor:
Timothy F. Jamison, Lara C. Czabaniuk
Publikováno v:
Organic letters. 17(4)
A new and highly selective method for the synthesis of hydroxyl-substituted tetrahydropyrans is described. This method utilizes titanium(IV) isopropoxide and diethyl tartrate to perform a diastereoselective epoxidation followed by in situ epoxide act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7033012377bada8906f115c11ae1bd6e
https://pubmed.ncbi.nlm.nih.gov/25647091
https://pubmed.ncbi.nlm.nih.gov/25647091
Autor:
Lara C. Czabaniuk, Barry M. Trost
Publikováno v:
ChemInform. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b249b5da5279115f8d08ecee467ed71
https://doi.org/10.1002/chin.201420231
https://doi.org/10.1002/chin.201420231
Autor:
Barry M. Trost, Lara C. Czabaniuk
Publikováno v:
ChemInform. 45
The asymmetric Pd-catalyzed benzylation of prochiral azlactones with a variety of benzylic-type compounds such as carbonates (I) and (IV) or phosphates such as (VI) and (VIII) by using enantiopure bis(diphenylphosphinobenzoyl)diamines as ligands is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd864262fe1625caf788d4e926c9fd8b
https://doi.org/10.1002/chin.201412123
https://doi.org/10.1002/chin.201412123
Autor:
Barry M. Trost, Lara C. Czabaniuk
Publikováno v:
Journal of the American Chemical Society. 132:15534-15536
Herein we report palladium-catalyzed asymmetric benzylic alkylation with 3-aryl oxindoles as prochiral nucleophiles. Proceeding analogously to asymmetric allylic alkylation, asymmetric benzylation occurs in high yield and enantioselectivity for a var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616b4e6f0962de4d1737f8cd0ce2f6fb
https://doi.org/10.1021/ja1079755
https://doi.org/10.1021/ja1079755
Autor:
Barry M, Trost, Lara C, Czabaniuk
Publikováno v:
Angewandte Chemie (International ed. in English). 53(11)
The coordination of transition metals to organic fragments can yield complexes with fascinating and unexpected binding patterns. The study of metal-benzyl complexes has demonstrated the feasibility of η(3)-coordination, which results in a dearomatiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b49e9e13d80a4a4b869d8fb8f367c882
https://pubmed.ncbi.nlm.nih.gov/24554487
https://pubmed.ncbi.nlm.nih.gov/24554487
Autor:
Lara C. Czabaniuk, Barry M. Trost
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 19(45)
Asymmetric benzylation of prochiral azlactone nucleophiles enables the catalytic introduction of a benzyl group towards the synthesis of α,α-disubstituted amino acids. Herein, we report an enantioselective palladium-catalyzed process using chiral b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f20a5f87138bafe1a9aa6fd469323d
https://pubmed.ncbi.nlm.nih.gov/24115047
https://pubmed.ncbi.nlm.nih.gov/24115047