Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lara Bonomi"'
Publikováno v:
Endocrinology. 154:2025-2033
The development of insulin resistance is tightly linked to fatty liver disease and is considered a major health concern worldwide, although their mechanistic relationship remains controversial. Activin has emerging roles in nutrient homeostasis, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300060c954445485adf2cee544ab3825
https://doi.org/10.1210/en.2012-1844
https://doi.org/10.1210/en.2012-1844
Autor:
Meghan Muse, Alan L. Schneyer, Lara Bonomi, Melissa L. Brown, Nathan Ungerleider, Martin M. Matzuk
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 303:E587-E596
Based on the phenotype of the activin-like kinase-7 (ALK7)-null mouse, activins A and B have been proposed to play distinct roles in regulating pancreatic islet function and glucose homeostasis, with activin A acting to enhance islet function and ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02618af8bfca6d32636340b6e6c4b88
https://doi.org/10.1152/ajpendo.00177.2012
https://doi.org/10.1152/ajpendo.00177.2012
Publikováno v:
Islets. 3:367-375
Members of the TGFβ superfamily, including activins and TGFβ, modulate glucose-stimulated insulin secretion (GSIS) in vitro using rat islets while genetic manipulations that reduce TGFβ superfamily signaling in vivo in mice produced hypoplastic is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3807f840787a94e484302af9109308
https://doi.org/10.4161/isl.3.6.18013
https://doi.org/10.4161/isl.3.6.18013
Publikováno v:
Endocrinology. 152:697-706
Follistatin (FST) is an antagonist of activin and related TGFβ superfamily members that has important reproductive actions as well as critical regulatory functions in other tissues and systems. FST is produced as three protein isoforms that differ i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aa490b862030d81da11c089577e4f9
https://doi.org/10.1210/en.2010-0950
https://doi.org/10.1210/en.2010-0950
Autor:
Yisrael Sidis, Fuminori Kimura, Jessica Zina, Lara Bonomi, Abir Mukherjee, Nathan Ungerleider, Melissa L. Brown, Alan L. Schneyer
Publikováno v:
Obesity (Silver Spring, Md.). 19(10)
Transforming growth factor-β superfamily ligands, including activin and myostatin, modulate body composition, islet function, and glucose homeostasis. Their bioactivity is controlled by the antagonists follistatin (FST) and FST like-3 (FSTL3). The h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa7bcb0888e12b6a76d19f5d445674b
https://pubmed.ncbi.nlm.nih.gov/21546932
https://pubmed.ncbi.nlm.nih.gov/21546932
Autor:
Melissa L. Brown, Amy S. Burnside, Alan L. Schneyer, Danielle Andrzejewski, Lara Bonomi, Nathan Ungerleider
Publikováno v:
Islets. 6:e1017226
Emerging evidence suggests that activin with its associated receptors, second messengers, and antagonists would be excellent targets for therapeutic drug development in the treatment of diabetes. We undertook the current study to investigate the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2085bcb0558720dd97734a439625574
https://doi.org/10.1080/19382014.2015.1017226
https://doi.org/10.1080/19382014.2015.1017226
Publikováno v:
Biology of Reproduction. 83:51-51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::562fdd3c03ef5390d84d298a37859bf6
https://doi.org/10.1093/biolreprod/83.s1.51
https://doi.org/10.1093/biolreprod/83.s1.51
Publikováno v:
Biology of Reproduction. 83:162-162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae4f349324d8b141211dff1888ffcdb3
https://doi.org/10.1093/biolreprod/83.s1.162
https://doi.org/10.1093/biolreprod/83.s1.162