Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Lara Barazzuol"'
Autor:
Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Hilmar R.J. van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P. Coppes, Inge R. Holtman, Bart J.L. Eggen, Susanne M. Kooistra, Lara Barazzuol
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113764- (2024)
Summary: Over half of patients with brain tumors experience debilitating and often progressive cognitive decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response to vari
Externí odkaz:
https://doaj.org/article/bae07cfdb73044fea7306f15d1eb7d28
Autor:
Cyprien G.J. Guerrin, Kavya Prasad, Daniel A. Vazquez-Matias, Jing Zheng, Maria Franquesa-Mullerat, Lara Barazzuol, Janine Doorduin, Erik F.J. de Vries
Publikováno v:
Neurobiology of Stress, Vol 27, Iss , Pp 100580- (2023)
Maternal infection during pregnancy and childhood social trauma have been associated with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum disorders, bipolar disorder and depression. These disorders are characterized
Externí odkaz:
https://doaj.org/article/6013f148061e45d7aa8301774c80516a
Autor:
Wejdan M. Arif, Philip H. Elsinga, Roel J.H.M. Steenbakkers, Walter Noordzij, Lara Barazzuol, Kelvin N.G. Wei Siang, Charlotte L. Brouwer, Bruno Lima Giacobbo, Rudi A.J.O. Dierckx, Ronald J.H. Borra, Gert Luurtsema
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 42, Iss , Pp 100652- (2023)
Background and purpose: Previous pre-clinical research using [18F]FDG-PET has shown that whole-brain photon-based radiotherapy can affect brain glucose metabolism. This study, aimed to investigate how these findings translate into regional changes in
Externí odkaz:
https://doaj.org/article/231ee542b3c5494ea02c6f0ddaab3c08
Autor:
Cyprien G.J. Guerrin, Janine Doorduin, Kavya Prasad, Daniel A. Vazquez-Matias, Lara Barazzuol, Erik F.J. de Vries
Publikováno v:
Neurobiology of Stress, Vol 23, Iss , Pp 100526- (2023)
Adverse experiences in early life can increase mental vulnerability to immune challenges experienced later in life, which may induce the development of stress-related psychopathologies. Here, we investigated whether the combined effect of both events
Externí odkaz:
https://doaj.org/article/2e07d0706b5b4e2181680fc9d909a84b
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality of life of the patients. Approaches aimed at regenera
Externí odkaz:
https://doaj.org/article/4ff52a72b99d41719bd822070fa3080b
Publikováno v:
Molecular Oncology, Vol 14, Iss 7, Pp 1538-1554 (2020)
Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of patients. The precision with which the radiation dose can be delivered is rapidly improving. This precision allows the more accurate targeting of radiation dose to the
Externí odkaz:
https://doaj.org/article/f34f2d1da4b44c90893f5e2cfd05d087
Autor:
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink
Publikováno v:
eLife, Vol 11 (2022)
A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer. A loss of ATM is also associated with increased p
Externí odkaz:
https://doaj.org/article/856b7f3066a9420b8c72ca00c91ef1e2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Adult stem cells ensure tissue homeostasis and regeneration after injury. Due to their longevity and functional requirements, throughout their life stem cells are subject to a significant amount of DNA damage. Genotoxic stress has recently been shown
Externí odkaz:
https://doaj.org/article/9bca5bb4426a4141ae12087b353f1897
Publikováno v:
Open Biology, Vol 11, Iss 4 (2021)
Genome instability and loss of protein homeostasis are hallmark events of age-related diseases that include neurodegeneration. Several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic
Externí odkaz:
https://doaj.org/article/9e62eec9c4c745558ac0b98994e49729
Autor:
Juan Villar-Vesga, Julián Henao-Restrepo, Daniëlle C. Voshart, David Aguillon, Andrés Villegas, Diana Castaño, Julián D. Arias-Londoño, Inge S. Zuhorn, Laís Ribovski, Lara Barazzuol, Gloria P. Cardona-Gómez, Rafael Posada-Duque
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Evidence suggests that extracellular vesicles (EVs) act as mediators and biomarkers of neurodegenerative diseases. Two distinct forms of Alzheimer disease (AD) are known: a late-onset sporadic form (SAD) and an early-onset familial form (FAD). Recent
Externí odkaz:
https://doaj.org/article/b8a7c53b691342daba3e611386f296c6