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Stability and suitability for storage and distribution of Ad26.ZEBOV/MVA-BN®-Filo heterologous prime-boost Ebola vaccine

Autor: Martinus A.H. Capelle, Janik Adriaansen, Ulrike Dirmeier, Doris Salerno, Britt Raaby, Kelly Krijgsman, Lara Babich, J.P. Els van Deventer-Troost

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics

The stability profile of a vaccine has important implications for storage, cold chain management and field deployment. The heterologous prime-boost Janssen Ebola vaccine regimen demonstrated an acceptable safety profile and durability of Ebola-specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588e76c46f7d44a9983c424573987a16
https://pubmed.ncbi.nlm.nih.gov/29870747

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Use of Hydrolases and Related Enzymes for Synthesis

Autor: Michael A. van der Horst, Lara Babich, Aloysius F. Hartog, Ron Wever

Publikováno v: Practical Methods for Biocatalysis and Biotransformations 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d56f43525352feb097c0203234abfbec
https://doi.org/10.1002/9781118697856.ch03

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Continuous-Flow Reactor-Based Enzymatic Synthesis of Phosphorylated Compounds on a Large Scale

Autor: Michael A. van der Horst, Ron Wever, Lara Babich, Aloysius F. Hartog

Publikováno v: Chemistry-A European Journal, 18(21), 6604-6609. Wiley-VCH Verlag

Acid phosphatase, an enzyme that is able to catalyze the transfer of a phosphate group from cheap pyrophosphate to alcoholic substrates, was covalently immobilized on polymethacrylate beads with an epoxy linker (Immobeads-150 or Sepabeads EC-EP). Aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131b95813a82bb64a26fa91cd57b7d68
https://doi.org/10.1002/chem.201200101

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Improvement of an acid phosphatase/DHAP-dependent aldolase cascade reaction by using directed evolution

Autor: Teunie van Herk, Ron Wever, Lara Babich, Aloysius F. Hartog, Hans E. Schoemaker

Publikováno v: ChemBioChem, 10(13), 2230-2235. Wiley-VCH Verlag

To enhance the phosphorylating activity of the bacterial nonspecific acid phosphatase from Salmonella enterica ser. typhimurium LT2 towards dihydroxyacetone (DHA), a mutant library was generated from the native enzyme. Three different variants that s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a33961da872ff2c484d36a90eb13ee2
https://doi.org/10.1002/cbic.200900102

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Phosphorylation by alkaline phosphatase: immobilization and synthetic potential

Autor: Aloysius F. Hartog, Ron Wever, Lara Babich, Joana L. V. M. Peralta

Publikováno v: International Journal of Chemistry, 5(3), 87-98

Phosphatases (AP, E.C. 3.1.3.1) are hydrolytic enzymes that naturally hydrolyse phosphomonoesters but in a so-called transphosphorylation reaction these enzymes are also able to transfer a phosphate group from phosphorylated compounds to alcoholic fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035796229cb10f990954b21325a23c18
https://dare.uva.nl/personal/pure/en/publications/phosphorylation-by-alkaline-phosphatase-immobilization-and-synthetic-potential(db4496ed-b592-41d4-aa32-b211ac3a008e).html

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Synthesis of carbohydrates in a continuous flow reactor by immobilized phosphatase and aldolase

Autor: Floris P. J. T. Rutjes, Ron Wever, Aloysius F. Hartog, Lara Babich, Lieke J. C. van Hemert

Publikováno v: Chemsuschem, 5, 2348-53
ChemSusChem, 5(12), 2348-2353. Wiley-VCH Verlag
Chemsuschem, 5, 12, pp. 2348-53

Contains fulltext : 103800.pdf (Publisher’s version ) (Open Access) Herein, we report a new flow process with immobilized enzymes to synthesize complex chiral carbohydrate analogues from achiral inexpensive building blocks in a three-step cascade r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ae53bfda0957556b95e9b1bfbcc378
http://hdl.handle.net/2066/103800

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