Výsledky vyhledávání - "Lara Almida Zimmermann"

Akademický článek

HPLC-ESI-MS/MS phenolic profile of ‟Nanicão Corupá' (Musa acuminata)

Autor: Amanda Rodrigues Borges, Ana Paula Jungston Capistrano, Camila Saatkamp, Luisana Lusia Silveira Utzig, Bruna Gonçalves Lopes, Julia Candiani dos Santos, Allan da Silva, Mayara Silva, Samantha Gonçalves, Gustavo Amadeu Micke, Luciano Vitali, Caio Cesar Sestile, Lara Almida Zimmermann, Vivian Binder Neis, Adrielli Tenfen

Publikováno v: Rodriguésia, Vol 72 (2021)

Abstract “Nanicão Corupá” (Musa acuminata) comes from Southern Brazil. The tropical climate in the region provides unique characteristics, including a sweeter flavor. This difference resulted in a Geographical Indication Recognition and Designa

Externí odkaz: https://doaj.org/article/68316c83509c418b9cc0c85ea538999f

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Caracterização dos compostos fenólicos, avaliação da toxicidade e análise da qualidade de amostras de chá de Miconia albicans

Autor: Gustavo Amadeu Micke, Bruna Hamann, Lara Almida Zimmermann, Diogo Alexandre Silbert, Adrielli Tenfen, Elisa Mara dos Santos Winter, Luciano Vitali

Publikováno v: Revista Fitos. 14:450-461

O uso de plantas medicinais como alternativa terapêutica é crescente na medicina popular. A espécie Miconia albicans, popularmente conhecida como canela de velho, está sendo consumida em várias regiões do país, por apresentar ação anti-infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f734be9ea2810539e61c3797721261fd
https://doi.org/10.32712/2446-4775.2020.1055

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Antiprotozoal agents: How have they changed over a decade?

Autor: Rafael da Rosa, Lílian Sibelle Campos Bernardes, Lara Almida Zimmermann, Arthur Eugen Kümmerle, Kamilla R. Rogério, Vitória de Souza Fernandes, Cedric Stephan Graebin

Publikováno v: Archiv der PharmazieREFERENCES. 355(2)

Neglected tropical diseases are a diverse group of communicable diseases that are endemic in low- or low-to-middle-income countries located in tropical and subtropical zones. The number and availability of drugs for treating these diseases are low, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2c316e7de5ff168359bb6c04d2b57d
https://pubmed.ncbi.nlm.nih.gov/34661935

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Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity

Autor: Lara Almida Zimmermann, Eduardo Borges de Melo, Lílian Sibelle Campos Bernardes, Fávero Reisdorfer Paula, Milene Höehr de Moraes, Rafael da Rosa, Mário Steindel, Eloir Paulo Schenkel

Publikováno v: Bioorganic & Medicinal Chemistry. 26:4850-4862

Despite the impressive scientific and technological advances of recent decades, no effective treatment is currently available for Chagas disease. Our research group has been studying the design and synthesis of analogues of natural lignans aiming to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388493a78780ac4f9c7c765ebc846fa9
https://doi.org/10.1016/j.bmc.2018.08.025

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Synthesis and biological evaluation of isoxazolyl-sulfonamides: A non-cytotoxic scaffold active against Trypanosoma cruzi, Leishmania amazonensis and Herpes Simplex Virus

Autor: Lílian Sibelle Campos Bernardes, Eloir Paulo Schenkel, Lara Almida Zimmermann, Mário Steindel, Rafael da Rosa, Naira Fernanda Zanchett Schneider, Cláudia Maria Oliveira Simões, Alice Duarte Schappo, Milene Höehr de Moraes

Publikováno v: Bioorganicmedicinal chemistry letters. 28(20)

In this study we report the synthesis, characterization, biological evaluation, and druglikeness assessment of a series of 20 novel isoxazolyl-sulfonamides, obtained by a four-step synthetic route. The compounds had their activity against Trypanosoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a10f6665b36a33efd1c58cd31b0d5
https://pubmed.ncbi.nlm.nih.gov/30194008

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Chemical Modification Produces Species-Specific Changes in Cucurbitacin Antifeedant Effect

Autor: Jorge Alejandro Palermo, Eloir Paulo Schenkel, Lara Almida Zimmermann, Carmen Rossini, Karen L. Lang, Vanessa Rocha Machado, Lílian Sibelle Campos Bernardes, Fernando Javier Duran, Emilio Deagosto

Publikováno v: Journal of Agricultural and Food Chemistry. 61:5534-5539

Cucurbitacins are secondary metabolites that mediate insect plant interactions not only as allomones against generalists but also as kairomones for specialist herbivores. This study was undertaken to identify the potential of cucurbitacin derivatives

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59154cb3faedf87ed6ce334ac32a4ae4
https://doi.org/10.1021/jf4002457

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Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives

Autor: Vanessa Rocha Machado, Fernando Javier Duran, Eloir Paulo Schenkel, Izabella Thaís Silva, Lílian Sibelle Campos Bernardes, María Ivana Lapuh, Karen Luise Lang, Gabriela M. Cabrera, Lara Almida Zimmermann, Jorge Alejandro Palermo, Marina Rodrigues Teixeira, Mariana Alejandra Galetti, Cláudia Maria Oliveira Simões, Miguel S. B. Caro

Publikováno v: Bioorganic & Medicinal Chemistry. 20(9):3016-3030

Two cucurbitacins, dihydrocucurbitacin B (1) and cucurbitacin B (2), which can be obtained in large amounts from the roots of Wilbrandia ebracteata and from the fruits of Luffa operculata, respectively, were used as starting materials for the prepara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47a49acd80177311b37e6343383e3e2

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Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line

Autor: Eloir Paulo Schenkel, Izabella Thaís Silva, Lara Almida Zimmermann, Fernando Javier Duran, Miguel S. B. Caro, Eduardo Borges de Melo, Vanessa Rocha Machado, Cláudia Maria Oliveira Simões, Karen L. Lang, Lílian Sibelle Campos Bernardes

Publikováno v: Journal of molecular graphicsmodelling. 48

This article describes structure–activity relationship (SAR/QSAR) studies on the cytotoxic activity in a human lung adenocarcinoma cell line (A549) of 43 cucurbitacin derivatives. Modeling was performed using the methods partial least squares with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db81002eed68a443ca8f65e5c4f79cb
https://pubmed.ncbi.nlm.nih.gov/24378396

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Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol

Autor: Lara Almida Zimmermann, María Victoria Mañalich Arana, Cláudia Maria Oliveira Simões, Fernando Javier Duran, Jorge Alejandro Palermo, Izabella Thaís Silva, Karen L. Lang, Miriam Falkenberg, Eloir Paulo Schenkel, Cintia Lhullier

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Marine Drugs
Marine Drugs, Vol 10, Iss 10, Pp 2254-2264 (2012)
Marine Drugs; Volume 10; Issue 10; Pages: 2254-2264

In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4734340f0d6d838ec0cd18934cf967ec
https://www.mdpi.com/1660-3397/10/10/2254

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