Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lara A. Haeusser"'
Autor:
Daniel J. Merk, Linda Paul, Foteini Tsiami, Helen Hohenthanner, Ghazal Mohseni Kouchesfahani, Lara A. Haeusser, Bianca Walter, Adam Brown, Nicole S. Persky, David E. Root, Ghazaleh Tabatabai
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Genome-wide functional screening using the CRISPR-Cas9 system is a powerful tool to uncover tumor-specific and common genetic dependencies across cancer cell lines. Current CRISPR-Cas9 knockout libraries, however, primarily target
Externí odkaz:
https://doaj.org/article/335008f1042a4c058cc57d3692251bc5
Autor:
Bianca Walter, Sophie Hirsch, Laurence Kuhlburger, Aaron Stahl, Leonard Schnabel, Silas Wisser, Lara A. Haeusser, Foteini Tsiami, Sarah Plöger, Narges Aghaallaei, Advaita M Dick, Julia Skokowa, Christian Schmees, Markus Templin, Katja Schenke-Layland, Marcos Tatagiba, Sven Nahnsen, Daniel J. Merk, Ghazaleh Tabatabai
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background The DNA damage response (DDR) is a physiological network preventing malignant transformation, e.g. by halting cell cycle progression upon DNA damage detection and promoting DNA repair. Glioblastoma are incurable primary tumors of
Externí odkaz:
https://doaj.org/article/facd8d65569547ca88e803ac3908a694
Autor:
Manfred Claassen, Federica Piccioni, Michael Spohn, Nicolas Casadei, Stephan Singer, Bianca Walter, Lara A. Haeusser, Ghazaleh Tabatabai, Jens Schittenhelm, Sophie Hirsch, Jakob Admar, David E. Root, Marcos Tatagiba, Daniel Merk, Nicole S. Persky, Sepideh Babaei, Foteini Tsiami, Ulrich Schüller, Cristiana Roggia
SummaryAtypical teratoid rhabdoid tumors (ATRT) are incurable high-grade pediatric brain tumors. Concepts for molecular-driven therapies in ATRTs lag behind, mainly due to the absence of actionable genetic alterations. We performed genome-wide CRISPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::488097de0eb434c9bfa3cac3a99bc6bc
https://doi.org/10.1101/2020.12.09.417378
https://doi.org/10.1101/2020.12.09.417378
Autor:
Ulrich Schüller, Jakob Admard, Stephan Singer, Bianca Walter, Cristiana Roggia, Sophie Hirsch, Federica Piccioni, Manfred Claassen, Michael Spohn, Foteini Tsiami, Sepideh Babaei, Ghazaleh Tabatabai, Nicolas Casadei, Jens Schittenhelm, Lara A. Haeusser, Nicole S. Persky, Marcos Tatagiba, David Root, Daniel Merk
Publikováno v:
Neuro-Oncology. 23:vi179-vi179
Brain tumors are the leading cause of cancer-related deaths in children. Embryonal brain tumors including medulloblastoma and atypical teratoid rhabdoid tumors (ATRTs) account for 15% of all primary brain and CNS tumors under the age of 14 years, wit
Autor:
Kerstin M Kampa-Schittenhelm, Julia Frey, Lara A. Haeusser, Marcus M Schittenhelm, Gunnar Blumenstock, Ashly A. Pavlovsky, Barbara Illing
Publikováno v:
Oncotarget. 8:82897-82909
Activating D816 mutations of the class III receptor tyrosine kinase KIT are associated with the majority of patients with systemic mastocytosis (SM), but also core binding factor (CBF) AML, making KIT mutations attractive therapeutic targets for the
Autor:
Kerstin Maria, Kampa-Schittenhelm, Julia, Frey, Lara A, Haeusser, Barbara, Illing, Ashly A, Pavlovsky, Gunnar, Blumenstock, Marcus Matthias, Schittenhelm
Publikováno v:
Oncotarget
Activating D816 mutations of the class III receptor tyrosine kinase KIT are associated with the majority of patients with systemic mastocytosis (SM), but also core binding factor (CBF) AML, making KIT mutations attractive therapeutic targets for the