Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Lara A Doyle"'
Autor:
Alexandra Melton, Lori A. Rowe, Toni Penney, Clara Krzykwa, Kelly Goff, Sarah E. Scheuermann, Hunter J. Melton, Kelsey Williams, Nadia Golden, Kristyn Moore Green, Brandon Smith, Kasi Russell-Lodrigue, Jason P. Dufour, Lara A. Doyle-Meyers, Faith Schiro, Pyone P. Aye, Jeffery D. Lifson, Brandon J. Beddingfield, Robert V. Blair, Rudolf P. Bohm, Jay K. Kolls, Jay Rappaport, James A. Hoxie, Nicholas J. Maness
Publikováno v:
Viruses, Vol 16, Iss 7, p 1173 (2024)
The effects of immunodeficiency associated with chronic HIV infection on COVID-19 disease and viral persistence have not been directly addressed in a controlled setting. In this pilot study, we exposed two pigtail macaques (PTMs) chronically infected
Externí odkaz:
https://doaj.org/article/6540d9832a1c4780aadcbb2a30855213
Autor:
Alyssa C. Fears, Edith M. Walker, Nicole Chirichella, Nadia Slisarenko, Kristen M. Merino, Nadia Golden, Breanna Picou, Skye Spencer, Kasi E. Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, Brandon J. Beddingfield, Nicholas J. Maness, Chad J. Roy, Namita Rout
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The dynamics of γδ T cell frequencies and functions through the course of SARS-CoV-2 infection in rhesus macaques and African green monkeys reveals that Vδ1 γδ T cells are involved in the early immune response to SARS-CoV-2 infection.
Externí odkaz:
https://doaj.org/article/18520bbe745343c7bc6104e42afbb428
Autor:
Xiaolei Wang, Eunice Vincent, Summer Siddiqui, Katherine Turnbull, Hong Lu, Robert Blair, Xueling Wu, Meagan Watkins, Widade Ziani, Jiasheng Shao, Lara A. Doyle-Meyers, Kasi E. Russell-Lodrigue, Rudolf P. Bohm, Ronald S. Veazey, Huanbin Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Neonates and infants infected with HIV generally develop disease rapidly, with early antiretroviral therapy (ART) often failing to achieve a sustained state of ART-free virologic remission. Here, the authors study viral reservoirs in neonatal macaque
Externí odkaz:
https://doaj.org/article/a089ce684ba34eaea4f2392b41d03fe2
Autor:
Ibolya Rutkai, Meredith G. Mayer, Linh M. Hellmers, Bo Ning, Zhen Huang, Christopher J. Monjure, Carol Coyne, Rachel Silvestri, Nadia Golden, Krystle Hensley, Kristin Chandler, Gabrielle Lehmicke, Gregory J. Bix, Nicholas J. Maness, Kasi Russell-Lodrigue, Tony Y. Hu, Chad J. Roy, Robert V. Blair, Rudolf Bohm, Lara A. Doyle-Meyers, Jay Rappaport, Tracy Fischer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
COVID-19 can result in neurological manifestations and animal models could provide insights into the mechanisms. Here, the authors describe neuroinflammation, microhemorrhages and brain hypoxia in SARS-CoV-2 infected non-human primates, including in
Externí odkaz:
https://doaj.org/article/0c1be27d8686492ebe212a4588149d65
Autor:
Brandon J. Beddingfield, Nicholas J. Maness, Skye Spencer, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, HongMei Gao, David Montefiori, Chad J. Roy
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSARS-CoV-2 is a respiratory pathogen currently causing a worldwide pandemic, with resulting pathology of differing severity in humans, from mild illness to severe disease and death. The rhesus macaque model of COVID-19 was utilized to eva
Externí odkaz:
https://doaj.org/article/3772dde98cab499297a36830dbf4d85e
Autor:
Alyssa C Fears, Brandon J Beddingfield, Nicole R Chirichella, Nadia Slisarenko, Stephanie Z Killeen, Rachel K Redmann, Kelly Goff, Skye Spencer, Breanna Picou, Nadia Golden, Cecily C Midkiff, Duane J Bush, Luis M Branco, Matthew L Boisen, Hongmei Gao, David C Montefiori, Robert V Blair, Lara A Doyle-Meyers, Kasi Russell-Lodrigue, Nicholas J Maness, Chad J Roy
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010618 (2022)
The novel coronavirus SARS-CoV-2 emerged in late 2019, rapidly reached pandemic status, and has maintained global ubiquity through the emergence of variants of concern. Efforts to develop animal models have mostly fallen short of recapitulating sever
Externí odkaz:
https://doaj.org/article/520e4f07330948dfb9dec099171ac336
Autor:
Scott P Lawrence, Samra E Elser, Workineh Torben, Robert V Blair, Bapi Pahar, Pyone P Aye, Faith Schiro, Dawn Szeltner, Lara A Doyle-Meyers, Beth S Haggarty, Andrea P O Jordan, Josephine Romano, George J Leslie, Xavier Alvarez, David H O'Connor, Roger W Wiseman, Christine M Fennessey, Yuan Li, Michael Piatak, Jeffrey D Lifson, Celia C LaBranche, Andrew A Lackner, Brandon F Keele, Nicholas J Maness, Mark Marsh, James A Hoxie
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010507 (2022)
The HIV/SIV envelope glycoprotein (Env) cytoplasmic domain contains a highly conserved Tyr-based trafficking signal that mediates both clathrin-dependent endocytosis and polarized sorting. Despite extensive analysis, the role of these functions in vi
Externí odkaz:
https://doaj.org/article/d548a853acc4469fa6a4e1326a82b9a7
Autor:
Alexandra Melton, Lara A Doyle-Meyers, Robert V Blair, Cecily Midkiff, Hunter J Melton, Kasi Russell-Lodrigue, Pyone P Aye, Faith Schiro, Marissa Fahlberg, Dawn Szeltner, Skye Spencer, Brandon J Beddingfield, Kelly Goff, Nadia Golden, Toni Penney, Breanna Picou, Krystle Hensley, Kristin E Chandler, Jessica A Plante, Kenneth S Plante, Scott C Weaver, Chad J Roy, James A Hoxie, Hongmei Gao, David C Montefiori, Joseph L Mankowski, Rudolf P Bohm, Jay Rappaport, Nicholas J Maness
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010162 (2021)
The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December 2021 with infections rising again due to the emergence of highly transmissible variants. Animal models that faithf
Externí odkaz:
https://doaj.org/article/a4d62fa7ec5b4fcc9a46c16a5466b091
Autor:
Brandon J. Beddingfield, Nicholas J. Maness, Alyssa C. Fears, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, Ann M. Carias, Patrick J. Madden, Ramon Lorenzo Redondo, Hongmei Gao, David Montefiori, Thomas J. Hope, Chad J. Roy
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
SARS-CoV-2 is a respiratory borne pathogenic beta coronavirus that is the source of a worldwide pandemic and the cause of multiple pathologies in man. The rhesus macaque model of COVID-19 was utilized to test the added benefit of combinatory parenter
Externí odkaz:
https://doaj.org/article/9bf5b7e52088482b9bde993ef28f1d7d
Autor:
Celeste Coleman, Lara A. Doyle-Meyers, Kasi E. Russell-Lodrigue, Nadia Golden, Breanna Threeton, Kejing Song, Genevieve Pierre, Carl Baribault, Rudolf P. Bohm, Nicholas J. Maness, Jay K. Kolls, Jay Rappaport, Joseph C. Mudd
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Understanding SARS-CoV-2 immune pathology is critical for the development of effective vaccines and treatments. Here, we employed unbiased serial whole-blood transcriptome profiling by weighted gene network correlation analysis (WGCNA) at pre-specifi
Externí odkaz:
https://doaj.org/article/a49f714b8f47477eaec5074ffa9368ff