Výsledky vyhledávání - "Lara A Aqrawi"

Akademický článek

Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome.

Autor: Lara A Aqrawi, Xiangjun Chen, Janicke Liaaen Jensen, Mathias Kaurstad Morthen, Bernd Thiede, Øygunn Aass Utheim, Øyvind Palm, Behzod Tashbayev, Tor Paaske Utheim, Hilde Kanli Galtung

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0205762 (2018)

Ocular dryness is a characteristic feature of primary Sjögren's syndrome (pSS). This may result in dry eye disease (DED), leading to damage of the ocular surface. Additional, non-invasive diagnostic techniques are needed when evaluating pSS patients

Externí odkaz: https://doaj.org/article/6cbc4cd810394539be7ddde974e6b248

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Akademický článek

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Autor: Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d’Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglænd Johnsen, Malin V. Jonsson, Marika Kvarnström, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martín, Gaétane Nocturne, Katrine Brække Norheim, Øyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Rönnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, PRECISESADS Clinical Consortium, Caroline H. Shiboski, Sjögren’s International Collaborative Clinical Alliance (SICCA), Marie Wahren-Herlenius, Wan-Fai Ng, UK Primary Sjögren’s Syndrome Registry, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)

Externí odkaz: https://doaj.org/article/38d950a26aca41828a73087f5c462f45

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Akademický článek

Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

The genetic architecture underlying Sjögren’s syndrome is not fully understood. Here, the authors perform a genome-wide association study to identify 10 new genetic risk regions, implicating genes involved in immune and salivary gland function.

Externí odkaz: https://doaj.org/article/ee17c34d06624822ae2f0ffc7f740171

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Akademický článek

Oral and ocular late effects in head and neck cancer patients treated with radiotherapy

Autor: Kristine Løken Westgaard, Håvard Hynne, Cecilie Delphin Amdal, Alix Young, Preet Bano Singh, Xiangjun Chen, Morten Rykke, Lene Hystad Hove, Lara A. Aqrawi, Tor P. Utheim, Bente Brokstad Herlofson, Janicke Liaaen Jensen

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract A broader understanding of oral and ocular late effects in head and neck cancer (HNC) patients who underwent intensity-modulated radiotherapy (IMRT) may provide valuable information in follow-up and improve quality of life. Twenty-nine HNC p

Externí odkaz: https://doaj.org/article/301bd4127dcd44f3a5e5c6bef88b8c31

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Akademický článek

Expression of NGAL-specific cells and mRNA levels correlate with inflammation in the salivary gland, and its overexpression in the saliva, of patients with primary Sjögren’s syndrome

Autor: Lara A. Aqrawi, Janicke Liaaen Jensen, Siren Fromreide, Hilde Kanli Galtung, Kathrine Skarstein

Publikováno v: Autoimmunity, Vol 53, Iss 6, Pp 333-343 (2020)

Salivary gland involvement is a characteristic feature of primary Sjögren’s syndrome (pSS), where tissue destruction is mediated by infiltrating immune cells, and may be accompanied by the presence of adipose tissue. Optimally diagnosing this mult

Externí odkaz: https://doaj.org/article/f1ed0bba0a8f48ef92b4c20c7fe07350

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Akademický článek

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)

Externí odkaz: https://doaj.org/article/75a032d749534f8d9af7665484459379

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Akademický článek

Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands

Autor: Tamandeep K. Bharaj, Lara A. Aqrawi, Siren Fromreide, Roland Jonsson, Johan G. Brun, Silke Appel, Kathrine Skarstein

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

There is a critical need to deconvolute the heterogeneity displayed by the minor salivary glands of primary Sjögren’s syndrome (pSS) patients. This is challenging primarily because the disease etiology remains unknown. The hypothesis includes that

Externí odkaz: https://doaj.org/article/276c0b069a334f989389051fe495e4cb

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Akademický článek

Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjögren’s syndrome

Autor: Kathrine Skarstein, Janicke Liaaen Jensen, Hilde Galtung, Roland Jonsson, Karl Brokstad, Lara A. Aqrawi

Publikováno v: Autoimmunity, Vol 52, Iss 7-8, Pp 242-250 (2019)

Salivary and lacrimal gland involvement is a characteristic feature of primary Sjögren’s syndrome (pSS), where tissue destruction is mediated by mononuclear cell infiltration, resulting in lacrimal and salivary gland impairment. We have previously

Externí odkaz: https://doaj.org/article/0a918da5bdfb4c1c83ccf2ca8cba79ad

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Akademický článek

Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers

Autor: Lara A. Aqrawi, Hilde Kanli Galtung, Eduarda M. Guerreiro, Reidun Øvstebø, Bernd Thiede, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Kathrine Skarstein, Janicke Liaaen Jensen

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)

Abstract Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca subjects, an un

Externí odkaz: https://doaj.org/article/91ca7a967ac246d88e1111cffcb50775

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Akademický článek

Signalling pathways identified in salivary glands from primary Sjögren’s syndrome patients reveal enhanced adipose tissue development

Autor: Lara A. Aqrawi, Janicke Liaaen Jensen, Gunnvor Øijordsbakken, Ann-Kristin Ruus, Ståle Nygård, Marit Holden, Roland Jonsson, Hilde Kanli Galtung, Kathrine Skarstein

Publikováno v: Autoimmunity, Vol 51, Iss 3, Pp 135-146 (2018)

A characteristic feature of primary Sjögren’s syndrome (pSS) is the destruction of salivary and lacrimal glands mediated by mononuclear cell infiltration. Adipocytes can also occupy a large portion of the salivary gland (SG) tissue area, although

Externí odkaz: https://doaj.org/article/0905697c06e4481485e4d0cace6611bc

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