Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Laporte Thomas L"'
Publikováno v:
Chemical Engineering in the Pharmaceutical Industry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717cdec23c9acfa7b70a6a11705afc33
https://doi.org/10.1002/9781119600800.ch14
https://doi.org/10.1002/9781119600800.ch14
Publikováno v:
Organic Process Research & Development. 19:819-830
Lipase PS 30 (immobilized on polypropylene) from Pseudomonas cepacia was used for enantioselective esterification of (RS)-1-(2-fluoro-4-iodophenyl)-3-hydroxypyrrolidin-2-one by using succinic anhydride and 2-methyltetrahydrofuran at 4 °C. The isolat
Autor:
Nanduri, Venkata B *, Hanson, Ronald L, Goswami, Animesh, Wasylyk, John M, LaPorte, Thomas L, Katipally, Kishta, Chung, Hyei-Jha, Patel, Ramesh N
Publikováno v:
In Enzyme and Microbial Technology 2001 28(7):632-636
Autor:
Steve S. Y. Wang, Paul C. Lobben, Jale Muslehiddinoglu, Laporte Thomas L, Lori Spangler, Steven H. Chan, Mourad Hamedi
Publikováno v:
Organic Process Research & Development. 18:1492-1502
A thermal runaway potential was identified for the conversion of a tertiary alcohol to a hydroxypyrrolotriazine intermediate in the synthesis of brivanib alaninate. A continuous process was developed to mitigate the potential thermal runaway and allo
Autor:
Daniel Wasser, Zhongmin Xu, Robert Wethman, Alan Braem, John M. Wasylyk, Shih-Ying Chang, Fernando Quiroz, David K. Leahy, James S. Bergum, Nathaniel Kopp, Paul C. Lobben, Jale Muslehiddinoglu, Laporte Thomas L, Dimitri Skliar, Evan Barlow, Frank Gibson, Lori Spangler, Chiajen Lai, Sushil K. Srivastava
Publikováno v:
Organic Process Research & Development. 19:900-907
This manuscript describes the control strategy for the commercial process to manufacture brivanib alaninate. The active pharmaceutical ingredient is a prodrug which is susceptible to hydrolysis. In addition to controlling hydrolysis, a robust strateg
Autor:
Gerard A. Crispino, Paul C. Lobben, Laporte Thomas L, Christos G. Papaioannou, Frederic G. Buono, Frank Gibson, Jaan A. Pesti, John E. Thornton, Lori Spangler
Publikováno v:
Organic Process Research & Development. 18:89-102
The development of a practical, commercial process for the preparation of 4-fluoro-2-methyl-indol-5-ol and its subsequent coupling with a pyrrolotriazine to form an advanced intermediate of the oncology therapy brivanib alaninate is described. A key
Autor:
Martin D. Johnson, Peter Poechlauer, Laporte Thomas L, Stefan G. Koenig, Anne O’Kearney-McMullan, Michael Jansen, Elizabeth Fisher, Juan Colberg, Benjamin Martin, Julie B. Manley, Michael Lawler
Publikováno v:
Organic Process Research & Development. 17:1472-1478
The American Chemical Society (ACS) Green Chemistry Institute (GCI) Pharmaceutical Roundtable conducted a study to elucidate the value of continuous processing, which had been defined as a key research area for green engineering. In the course of def
Autor:
Hanson, Ronald L *, Howell, Jeffrey M, LaPorte, Thomas L, Donovan, Mary Jo, Cazzulino, Dana L, Zannella, Valerie, Montana, Michael A, Nanduri, Venkata B, Schwarz, Steven R, Eiring, Ronald F, Durand, Susan C, Wasylyk, John M, Parker, William L, Liu, Mark S, Okuniewicz, Francis J, Chen, Bang-Chi, Harris, John C, Natalie, Kenneth J, Jr, Ramig, Keith, Swaminathan, Shankar, Rosso, Victor W, Pack, Shawn K, Lotz, Bruce T, Bernot, Peter J, Rusowicz, Andrew, Lust, David A, Tse, Kai S, Venit, John J, Szarka, Laszlo J, Patel, Ramesh N
Publikováno v:
In Enzyme and Microbial Technology 2000 26(5):348-358
Autor:
Patel, Ramesh N *, Banerjee, Amit, Nanduri, Venkata B, Goldberg, Steven L, Johnston, Robert M, Hanson, Ronald L, McNamee, Clyde G, Brzozowski, David B, Tully, Thomas P, Ko, Raphael Y, LaPorte, Thomas L, Cazzulino, Dana L, Swaminathan, Shankar, Chen, Chien-Kuang, Parker, Larry W, Venit, John J
Publikováno v:
In Enzyme and Microbial Technology 2000 27(6):376-389
Autor:
Laporte Thomas L, Ramesh N. Patel, Ronald L. Hanson, David B. Brzozowski, Dane M. Springer, James A. Matson
Publikováno v:
Organic Process Research & Development. 6:482-487
Biotransformation of mutilin and pleuromutilin by microbial cultures was investigated to provide a source of 8-hydroxymutilin or 8-hydroxypleuromutilin. LC/MS analysis of culture broths showed that...