Synthesis of 1,3,5-triphenyl-1,2,4-triazole derivatives and their neuroprotection by anti-oxidative stress and anti-inflammation and protecting BBB

Autor: Wang, Yang, Su, Ruiqi, Chen, Jianwen, Liu, Xuan, Luo, Jingning, Lao, Yaoqiang, Huang, Ping, Shi, Jinguo, Jiang, Caibao, Liao, Liping, Zhang, Jingxia

Publikováno v: In European Journal of Medicinal Chemistry 15 November 2023 260

Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury

Autor: Lao, Yaoqiang, Wang, Yang, Chen, Jianwen, Huang, Ping, Su, Ruiqi, Shi, Jinguo, Jiang, Caibao, Zhang, Jingxia

Publikováno v: In European Journal of Medicinal Chemistry 5 June 2022 236

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The Neuroprotection of 1,2,4-Triazole Derivative by Inhibiting Inflammation and Protecting BBB Integrity in Acute Ischemic Stroke.

Autor: Liu X; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Luo J; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Chen J; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Huang P; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., He G; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Ye X; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Su R; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Lao Y; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Wang Y; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., He X; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China., Zhang J; Department of Medicinal Chemistry, School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, China.

Publikováno v: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Nov; Vol. 30 (11), pp. e70113.