Zobrazeno 1 - 10
of 759
pro vyhledávání: '"Lao, H."'
Autor:
Tommaso De Marchi, Chun-Fui Lai, Georgia M. Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H. Saal, Johan Malmström, Simak Ali, Emma Niméus
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic
Externí odkaz:
https://doaj.org/article/d1192d9df9934484a96a115d8dfd7398
Autor:
Pei Meng, Hina Dalal, Yilun Chen, Christian Brueffer, Sergii Gladchuk, Miguel Alcaide, Anna Ehinger, Lao H. Saal
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract HER2/ERBB2 evaluation is necessary for treatment decision-making in breast cancer (BC), however current methods have limitations and considerable variability exists. DNA copy number (CN) evaluation by droplet digital PCR (ddPCR) has compleme
Externí odkaz:
https://doaj.org/article/f860143035084445832901bac01327da
Autor:
Yanni Li, Kristina Sundquist, Sakshi Vats, Mun-Gwan Hong, Xiao Wang, Yilun Chen, Anna Hedelius, Lao H. Saal, Jan Sundquist, Ashfaque A. Memon
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range
Externí odkaz:
https://doaj.org/article/cb06c35a947c4ac0ba4677cdc3e5c32a
Autor:
Kamil Demircan, Ylva Bengtsson, Thilo Samson Chillon, Johan Vallon-Christersson, Qian Sun, Christer Larsson, Martin Malmberg, Lao H. Saal, Lisa Rydén, Åke Borg, Jonas Manjer, Lutz Schomburg
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Introduction Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence circulating selenium
Externí odkaz:
https://doaj.org/article/cff4db4e410142088f7f14e1fff6b03b
Autor:
Malin Dahlgren, Barbara Lettiero, Hina Dalal, Kira Mårtensson, Alexander Gaber, Björn Nodin, Sofia K. Gruvberger-Saal, Lao H. Saal, Jillian Howlin
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-9 (2023)
Abstract Objective To investigate CITED1 as a potential biomarker of anti-endocrine response and breast cancer recurrence, given its previously determined role in mediating estrogen-dependant transcription. The study is a continuation of earlier work
Externí odkaz:
https://doaj.org/article/c9c6f678180546e18206439af403ab2a
Autor:
Bengtsson, Ylva, Demircan, Kamil, Vallon-Christersson, Johan, Malmberg, Martin, Saal, Lao H., Rydén, Lisa, Borg, Åke, Schomburg, Lutz, Sandsveden, Malte, Manjer, Jonas
Publikováno v:
In Redox Biology July 2023 63
Autor:
Ylva Bengtsson, Kamil Demircan, Johan Vallon-Christersson, Martin Malmberg, Lao H. Saal, Lisa Rydén, Åke Borg, Lutz Schomburg, Malte Sandsveden, Jonas Manjer
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102728- (2023)
Background: The essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that these elements may impact breast cancer survival. However, no epidemiological stud
Externí odkaz:
https://doaj.org/article/ac6535fc042b4568a29bc927b1b4e96e
Autor:
Johan Staaf, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Siker Kimbung, Ingrid Hedenfalk, Tonje Lien, Therese Sørlie, Bjørn Naume, Hege Russnes, Rachel Marcone, Ayyakkannu Ayyanan, Cathrin Brisken, Rebecka R. Malterling, Bengt Asking, Helena Olofsson, Henrik Lindman, Pär-Ola Bendahl, Anna Ehinger, Christer Larsson, Niklas Loman, Lisa Rydén, Martin Malmberg, Åke Borg, Johan Vallon-Christersson
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (
Externí odkaz:
https://doaj.org/article/d2e56c524d0b4a448d746df4499518bd
Autor:
Demircan, Kamil, Sun, Qian, Bengtsson, Ylva, Seemann, Petra, Vallon-Christersson, Johan, Malmberg, Martin, Saal, Lao H., Rydén, Lisa, Minich, Waldemar B., Borg, Åke, Manjer, Jonas, Schomburg, Lutz
Publikováno v:
In Redox Biology July 2022 53
Autor:
Hina Dalal, Malin Dahlgren, Sergii Gladchuk, Christian Brueffer, Sofia K. Gruvberger-Saal, Lao H. Saal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Estrogen receptor alpha (ERα, encoded by ESR1) is a well-characterized transcription factor expressed in more than 75% of breast tumors and is the key biomarker to direct endocrine therapies. On the other hand, much less is known about estr
Externí odkaz:
https://doaj.org/article/d4846f6f066d4b8e98d670e12b1413cf