Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot.

Autor: Barrios EL; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Mazer MB; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., McGonagill PW; Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Bergmann CB; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; University Hospital Ulm, Clinic for Trauma Surgery, Hand, Plastic, and Reconstructive Surgery Albert-Einstein-Allee 23, Ulm, Germany., Goodman MD; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Gould RW; Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Rao M; Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Polcz VE; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Davis RJ; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Del Toro DE; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Dirain ML; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Dram A; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Hale LO; Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Heidarian M; Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Kim CY; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Kucaba TA; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Lanz JP; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., McCray AE; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Meszaros S; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Miles S; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Nelson CR; Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Rocha IL; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Silva EE; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Ungaro RF; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Walton AH; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Xu J; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Zeumer-Spataro L; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Drewry AM; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Liang M; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.; Department of Biostatistics, University of Florida College of Public Health and Health Professions and the University of Florida College of Medicine, Gainesville, Florida, USA., Bible LE; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Loftus TJ; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Turnbull IR; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Efron PA; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Remy KE; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Brakenridge SC; Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington, USA., Badovinac VP; Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.; Experimental Pathology PhD Program, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Griffith TS; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Minneapolis VA Healthcare System, Minneapolis, Minnesota, USA., Moldawer LL; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Hotchkiss RS; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Caldwell CC; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Jan 23; Vol. 9 (2). Date of Electronic Publication: 2024 Jan 23.