Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Lanthionine Ketimine"'
Autor:
Marni E. Harris-White, Kathie G. Ferbas, Ming F. Johnson, Pirooz Eslami, Aleksandra Poteshkina, Kalina Venkova, Alexandar Christov, Kenneth Hensley
Publikováno v:
Neurobiology of Disease, Vol 84, Iss , Pp 60-68 (2015)
Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimin
Externí odkaz:
https://doaj.org/article/53d44422aa2942b4a406d6bc8bb0da61
Akademický článek
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Autor:
Hannah Leppert, Rajesh Khanna, Jacob T. Cain, Jon Brudvig, Jill M. Weimer, Brandon Meyerink, Bryon Grove, Katherine A. White, Kenneth Hensley, Derek J. Timm, Tyler B. Johnson, Helen Magee, Mitch Rechtzigel, Seung yon Koh, Jeremy P. Morgan
As neurons establish extensive connections throughout the central nervous system, the transport of cargo along the microtubule network of the axon is crucial for differentiation and homeostasis. Specifically, building blocks such as membrane and cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12816852f832009f02e8ae244e2427a6
https://doi.org/10.1101/2021.09.16.460653
https://doi.org/10.1101/2021.09.16.460653
Autor:
Kenneth Hensley, Katarzyna Kowal, Douglas L. Feinstein, Ruth N. Muchiri, Richard B. van Breemen
Publikováno v:
Rapid Communications in Mass Spectrometry. 32:1941-1948
RATIONALE Preclinical studies in the search for treatments for several neurodegenerative diseases have identified lanthionine ketimine (LK) and its monoethyl ester derivative (LKE) as potential candidates. An ultrahigh-pressure liquid chromatography/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c1f0c59ac8781dbbccf0533b334f29
https://doi.org/10.1002/rcm.8263
https://doi.org/10.1002/rcm.8263
Publikováno v:
Neurochemistry International. 115:61-68
Okadaic acid (OKA) is a protein phosphatase 2A inhibitor that is used to induce neurodegeneration and study disease states such as Alzheimer's disease (AD). Lanthionine ketimine-5-ethyl ester (LKE) is a bioavailable derivative of the naturally occurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e90d536178756e534244b1b466a74e3
https://doi.org/10.1016/j.neuint.2018.02.002
https://doi.org/10.1016/j.neuint.2018.02.002
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:562-565
The multiple-step, one-pot procedure for a series of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates, analogues of the natural, sulfur amino acid metabolite lanthionine ketimine (LK), its 5-ethyl ester (LKE) and 2-substituted LKEs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1fb66ae2e369a6d6b8e515212d6750
https://doi.org/10.1016/j.bmcl.2018.01.052
https://doi.org/10.1016/j.bmcl.2018.01.052
Publikováno v:
Neuroscience Letters. 664:28-33
Lanthionine ketimine ethyl ester (LKE) is a synthetic derivative of the naturally occurring amino acid lanthionine ketimine. We previously showed that LKE reduced clinical signs in a mouse model of multiple sclerosis (MS) associated with reductions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc6dc39e8c89369b53ec688be2b8b43
https://doi.org/10.1016/j.neulet.2017.11.018
https://doi.org/10.1016/j.neulet.2017.11.018
Publikováno v:
Amino Acids. 49:747-759
Collapsin response mediator protein 2 (CRMP-2) is a neuronal protein involved in axonal pathfinding. Intense research is focusing on its role in various neurological diseases. Despite a wealth of studies, not much is known about the molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc849984404958671bac6e34991236c3
https://doi.org/10.1007/s00726-016-2376-z
https://doi.org/10.1007/s00726-016-2376-z
Publikováno v:
Biochemical and Biophysical Research Communications. 483:759-764
The mammalian central nervous system (CNS) has limited regenerative ability after injury, largely due to scar formation and axonal growth inhibitors. Experimental suppression of neuroinflammation encourages recovery from spinal cord injury (SCI), yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd57ee10d9fc6449a7b1e9205bc92be
https://doi.org/10.1016/j.bbrc.2016.12.069
https://doi.org/10.1016/j.bbrc.2016.12.069
Autor:
Sergey Kalinin, Kathy Kowal, Natalia Marangoni, Douglas L. Feinstein, Kinga Lis, Kenneth Hensley, Jeffrey L. Dupree, Lucia Lisi, Rajesh Khanna, Shao Xia Lin, Aubin Moutal
Publikováno v:
ASN Neuro, Vol 11 (2019)
ASN NEURO
ASN NEURO
We previously showed that treatment with lanthionine ketimine ethyl ester (LKE) reduced disease severity and axonal damage in an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis and increased neuronal maturation and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae4b56d3c1fe7d993b3c4bca27c7859
https://doaj.org/article/edd02eb328f24478881a1a8638ea6b9e
https://doaj.org/article/edd02eb328f24478881a1a8638ea6b9e